NIR-Responsive Free Standing Borophene Mediates Photothermal and Photodynamic Therapy to Reduce Bacterial Biofilm Burden.
| Title: | NIR-Responsive Free Standing Borophene Mediates Photothermal and Photodynamic Therapy to Reduce Bacterial Biofilm Burden. |
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| Authors: | Vincy A; Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Karwar 342030, India.; Anand V; Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Karwar 342030, India.; Kannan DK; Graduate Institute of Biomaterials and Tissue Engineering (GIBMTE), College of Biomedical Engineering, Taipei Medical University, Shuang-Ho Campus, New Taipei City 235603, Taiwan R.O.C.; Pandith A; International Ph.D. Program in Biomedical Engineering (IPBME), College of Biomedical Engineering, Taipei Medical University, Shuang-Ho Campus, New Taipei City 235603, Taiwan R.O.C.; Gurnani B; Centre of Excellence-AyurTech, Indian Institute of Technology Jodhpur, Karwar 342030, India.; Ranjan P; Department of Metallurgical and Materials Engineering, Indian Institute of Technology Jodhpur, Karwar 342030, India.; Pathak A; Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Karwar 342030, India.; Jain N; Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Karwar 342030, India.; Chahal S; Department of Physics, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana 502285, India.; Kumar P; Department of Applied Sciences, School of Advanced Engineering, University of Petroleum and Energy Studies, Energy Acres, Bidholi Campus, P.O. Bidholi, Via Prem Nagar, Uttarakhand 248007, India.; Global Innovative Centre for Advanced Nanomaterials (GICAN), University of Newcastle, Newcastle, NSW 2308, Australia.; Vankayala R; Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Karwar 342030, India.; Interdisciplinary Research Division Smart Healthcare, Indian Institute of Technology Jodhpur, Karwar 342030, India. |
| Source: | ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2025 Dec 17; Vol. 17 (50), pp. 67690-67704. Date of Electronic Publication: 2025 Dec 06. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, D.C. : American Chemical Society |
| MeSH Terms: | Biofilms*/drug effects ; Photosensitizing Agents*/chemistry ; Photosensitizing Agents*/pharmacology ; Anti-Bacterial Agents*/pharmacology ; Anti-Bacterial Agents*/chemistry ; Nanostructures*/chemistry ; Boron Compounds*/chemistry ; Boron Compounds*/pharmacology ; Photochemotherapy*; Singlet Oxygen/metabolism ; Zebrafish ; Animals ; Infrared Rays ; Humans |
| Abstract: | Bacterial biofilms in open clinical wounds drive persistent infections, antibiotic resistance, and chronic inflammation, posing significant treatment challenges. Traditional therapies, including surgical debridement and antibiotics, are increasingly ineffective due to resistant strains. Light-activatable photosensitizers offer promise but are limited by poor tissue penetration and rapid photobleaching, especially in the UV/visible spectrum. Here, we introduce free-standing borophene nanosheets (B NSs) as a photoactivatable nanomaterial operating within the NIR-I and NIR-II biological windows. The B NSs demonstrate high photothermal conversion efficiencies (∼32% in NIR-I, 26.3% in NIR-II) and efficiently generate singlet oxygen under NIR irradiation. Functionally, B NSs effectively inhibit biofilm formation and eradicate mature biofilms ex vivo, while exhibiting minimal toxicity in vivo in a zebrafish model. These findings highlight B NSs as a promising, noninvasive approach for combating antibiotic-resistant biofilms with potential for clinical translation. |
| Comments: | Erratum in: ACS Appl Mater Interfaces. 2026 Mar 5. doi: 10.1021/acsami.6c03914.. (PMID: 41784609) |
| Contributed Indexing: | Keywords: biofilms; borophene; near-infrared; photodynamic therapy; photothermal therapy |
| Substance Nomenclature: | 0 (Photosensitizing Agents); 0 (Anti-Bacterial Agents); 0 (Boron Compounds); 17778-80-2 (Singlet Oxygen) |
| Entry Date(s): | Date Created: 20251206 Date Completed: 20251218 Latest Revision: 20260305 |
| Update Code: | 20260305 |
| DOI: | 10.1021/acsami.5c19368 |
| PMID: | 41351515 |
| Database: | MEDLINE |
Journal Article