Carbon Monoxide Poisoning-Induced Myositis.
| Title: | Carbon Monoxide Poisoning-Induced Myositis. |
|---|---|
| Authors: | Abid C; Department of Rheumatology, Hedi Chaker University Hospital, Sfax, Tunisia.; Gassara Z; Department of Rheumatology, Hedi Chaker University Hospital, Sfax, Tunisia.; Feki A; Department of Rheumatology, Hedi Chaker University Hospital, Sfax, Tunisia.; Benjemaa S; Department of Rheumatology, Hedi Chaker University Hospital, Sfax, Tunisia.; Kallel MH; Department of Rheumatology, Hedi Chaker University Hospital, Sfax, Tunisia.; Baklouti S; Department of Rheumatology, Hedi Chaker University Hospital, Sfax, Tunisia.; Fourati H; Department of Rheumatology, Hedi Chaker University Hospital, Sfax, Tunisia. |
| Source: | European journal of case reports in internal medicine [Eur J Case Rep Intern Med] 2025 Dec 03; Vol. 12 (12), pp. 005874. Date of Electronic Publication: 2025 Dec 03 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: SMC Media Country of Publication: Italy NLM ID: 101648453 Publication Model: eCollection Cited Medium: Internet ISSN: 2284-2594 (Electronic) Linking ISSN: 22842594 NLM ISO Abbreviation: Eur J Case Rep Intern Med Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Milano : SMC Media, [2014]- |
| Abstract: | Introduction: Carbon monoxide (CO) poisoning is common and potentially life-threatening. While neurological and systemic complications are well recognized, muscle involvement, such as myositis, is rare.; Case Presentation: We report a 38-year-old man with no prior medical history who suffered CO poisoning after inhaling motorcycle exhaust in a closed garage, presenting in coma. He received intensive care and hyperbaric oxygen therapy. One month later, he experienced persistent right thigh myalgia and quadriceps weakness. Laboratory tests were normal, but magnetic resonance imaging (MRI) revealed T2 and fat saturation hypersignal with gadolinium enhancement in the vastus lateralis over 9 cm, consistent with active myositis. Electromyography and X-ray were unremarkable. Other causes, including drug-induced myositis, inflammatory myopathies, and endocrine disorders, were excluded. Treatment with anti-inflammatory medications and rest alleviated pain, though mild weakness persisted. Follow-up MRI at 4 months showed regression of the lesions.; Discussion: CO-induced myositis results from tissue hypoxia via the high affinity of CO for myoglobin and inhibition of cytochrome oxidases, sometimes exacerbated by compression during coma. Diagnosis relies on clinical history, elevated muscle enzymes, and MRI, which provides a non-invasive alternative to biopsy.; Conclusion: Myositis is a rare complication of CO poisoning. Early recognition and hyperbaric oxygen therapy are essential, with MRI serving as a valuable diagnostic tool to guide management and monitor recovery.; Learning Points: Carbon monoxide (CO) poisoning can, in rare cases, cause myositis: Doctors should consider muscle involvement in patients presenting with persistent myalgia or weakness after CO exposure.Magnetic resonance imaging is a key diagnostic tool: It provides a non-invasive method to detect muscle damage, monitor progression, and may reduce the need for biopsy.Early recognition and hyperbaric oxygen therapy are crucial. Timely intervention may limit muscle damage and improve patient outcomes.; (© EFIM 2025.) |
| Competing Interests: | Conflicts of Interests: The Authors declare that there are no competing interests. |
| References: | J Korean Med Sci. 2001 Jun;16(3):253-61. (PMID: 11410684); Undersea Hyperb Med. 2019 Jan-Feb;46(1):63-67. (PMID: 31154686); J Coll Physicians Surg Pak. 2022 Dec;32(12):SS162-SS164. (PMID: 36597326); Am J Emerg Med. 1994 May;12(3):347-9. (PMID: 8179748) |
| Contributed Indexing: | Keywords: Carbon monoxide poisoning; hyperbaric oxygen therapy; myositis |
| Entry Date(s): | Date Created: 20251211 Date Completed: 20251211 Latest Revision: 20251213 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12688571 |
| DOI: | 10.12890/2025_005874 |
| PMID: | 41377783 |
| Database: | MEDLINE |
Journal Article