The Association of Mild Kidney Disease With Coronary Artery Disease Is Stronger for People Living With HIV.
| Title: | The Association of Mild Kidney Disease With Coronary Artery Disease Is Stronger for People Living With HIV. |
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| Authors: | Doshi S; Departments of Global Health.; Richardson BA; Departments of Global Health.; Biostatistics, University of Washington, Seattle, WA.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.; Nazzinda R; Joint Clinical Research Centre, Kampala, Uganda.; Mugerwa H; Joint Clinical Research Centre, Kampala, Uganda.; Bittencourt MS; Department of Medicine, University of Pittsburgh, Pittsburgh, PA.; Erem G; Department of Radiology, Nsambya Hospital, Kampala, Uganda.; Department of Radiology, Makerere University, Kampala, Uganda.; Narendrula A; Department of Medicine, New York University, New York, NY.; Farquhar C; Departments of Global Health.; Departments of Medicine; and.; Epidemiology, University of Washington, Seattle, WA.; Kityo C; Joint Clinical Research Centre, Kampala, Uganda.; Longenecker CT; Departments of Global Health.; Departments of Medicine; and. |
| Source: | Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2026 Jan 01; Vol. 101 (1), pp. 95-102. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Lippincott Williams & Wilkins, Inc Country of Publication: United States NLM ID: 100892005 Publication Model: Print Cited Medium: Internet ISSN: 1944-7884 (Electronic) Linking ISSN: 15254135 NLM ISO Abbreviation: J Acquir Immune Defic Syndr Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, Inc., c1999- |
| MeSH Terms: | HIV Infections*/complications ; Coronary Artery Disease*/complications ; Coronary Artery Disease*/epidemiology ; Kidney Diseases*/complications; Uganda/epidemiology ; Humans ; Female ; Male ; Middle Aged ; Cross-Sectional Studies ; Glomerular Filtration Rate ; Risk Factors |
| Abstract: | Objective: To examine the association between mild kidney disease and coronary plaque parameters using coronary computed tomography angiography in people living with HIV (PWH) compared with people without HIV in Uganda.; Design: Cross-sectional secondary analysis.; Methods: We studied 165 participants aged >45 years with ≥1 cardiovascular risk factor (78 PWH on stable antiretroviral therapy, 87 HIV-negative). Kidney function was assessed using estimated glomerular filtration rate (eGFR) and albumin-creatinine ratio (ACR). Coronary artery disease (CAD) was characterized by segment involvement score (SIS), segment stenosis score (SSS), and coronary artery calcium score. Multivariable Tobit regression assessed associations of kidney function measures with CAD parameters, testing for differences by HIV status.; Results: The median (interquartile range) age was 57.0 (53-62) years, 62.4% of subjects were female, and 87.3% had hypertension. Among PWH, mildly impaired eGFR ( 0.07).; Conclusion: In PWH, mildly reduced eGFR was associated with greater coronary plaque burden (SIS, SSS) but not coronary artery calcium; ACR showed no associations with any CAD measures. Incorporating kidney function measures into cardiovascular risk assessment may be valuable in HIV care.; (Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.) |
| Competing Interests: | C.T.L. has served on advisory boards for Gilead Sciences and Theratechnologies. B.A.R. has served on Data Safety Monitoring Boards for Gilead Sciences. The remaining authors have no funding or conflicts of interest to disclose. |
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| Grant Information: | D43 TW011596 United States TW FIC NIH HHS; K23 HL123341 United States HL NHLBI NIH HHS; P30 AI027757 United States AI NIAID NIH HHS |
| Contributed Indexing: | Keywords: HIV; coronary CT angiography; coronary artery disease; kidney dysfunction |
| Entry Date(s): | Date Created: 20251211 Date Completed: 20251211 Latest Revision: 20260318 |
| Update Code: | 20260318 |
| PubMed Central ID: | PMC12703689 |
| DOI: | 10.1097/QAI.0000000000003765 |
| PMID: | 41380171 |
| Database: | MEDLINE |
Journal Article