Impact of Metastatic Hormone-sensitive Prostate Cancer Treatments on Health-related Quality of Life: A Systematic Review and Network Meta-analysis.
| Title: | Impact of Metastatic Hormone-sensitive Prostate Cancer Treatments on Health-related Quality of Life: A Systematic Review and Network Meta-analysis. |
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| Authors: | van Elst T; Department of Urology, Santeon Hospital Group, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands; Department of Medical Oncology, Radboudumc, Nijmegen, The Netherlands. Electronic address: T.vanElst@cwz.nl.; Lopez P; Grupo de Pesquisa em Exercício para Populações Clínicas (GPCLIN), Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Ciências da Saúde, Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil; Pleural Medicine Unit, Institute for Respiratory Health, Perth, Western Australia, Australia.; Buffart LM; Department of Medical BioSciences, Radboudumc, Nijmegen, The Netherlands.; Custers JAE; Department of Medical Psychology, Radboudumc, Nijmegen, The Netherlands.; Wever L; Department of Urology, St Antonius Hospital, Nieuwegein, The Netherlands.; de Bie JC; Department of Medical Oncology, Radboudumc, Nijmegen, The Netherlands.; Mulders PFA; Department of Urology, Radboudumc, Nijmegen, The Netherlands.; Bloemendal HJ; Department of Medical Oncology, Radboudumc, Nijmegen, The Netherlands.; van Basten JA; Department of Urology, Santeon Hospital Group, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.; Mehra N; Department of Medical Oncology, Radboudumc, Nijmegen, The Netherlands. |
| Source: | European urology focus [Eur Urol Focus] 2025 Dec 11. Date of Electronic Publication: 2025 Dec 11. |
| Publication Model: | Ahead of Print |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101665661 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-4569 (Electronic) Linking ISSN: 24054569 NLM ISO Abbreviation: Eur Urol Focus Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier B.V., [2015]- |
| Abstract: | Background and Objective: In metastatic hormone-sensitive prostate cancer (mHSPC), health-related quality of life (HRQoL) is key for personalised treatment decisions. We compared the impact of different mHSPC treatment strategies on HRQoL, tackling a previously unaddressed challenge in comparing the outcomes across different patient-reported outcome measures (PROMs).; Methods: A systematic review was conducted of prospective studies reporting HRQoL outcomes of androgen deprivation therapy (ADT) alone or with placebo, radiotherapy, abiraterone, apalutamide, enzalutamide, and/or docetaxel in mHSPC (CRD42021227902). Databases were searched in April 2022 and April 2024. HRQoL domains across different PROMs were harmonised using the Wilson and Cleary model. A frequentist network meta-analysis (NMA) compared 12-mo treatment effects using standardised mean differences (SMDs) with 95% confidence intervals (CIs). Statistical significance was defined as p |
| Contributed Indexing: | Keywords: Androgen-receptor pathway inhibitor; Docetaxel; Fatigue; Health-related quality of life; Meta-analysis; Metastatic hormone-sensitive prostate cancer; Overall quality of life; Pain; Patient-reported outcome measures; Radiotherapy |
| Entry Date(s): | Date Created: 20251212 Latest Revision: 20251212 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.euf.2025.12.001 |
| PMID: | 41387022 |
| Database: | MEDLINE |
Journal Article; Review