Oxygenation Index and Oxygen Saturation Index in Congenital Diaphragmatic Hernia: Do Management Guidelines Make a Difference?
| Title: | Oxygenation Index and Oxygen Saturation Index in Congenital Diaphragmatic Hernia: Do Management Guidelines Make a Difference? |
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| Authors: | Ellsworth TS; Divisions of Neonatology, University of Utah School of Medicine and Primary Children's Hospital, Intermountain Healthcare Salt Lake City, Salt Lake City, Utah, USA.; Carpenter RJ; Divisions of Neonatology, University of Utah School of Medicine and Primary Children's Hospital, Intermountain Healthcare Salt Lake City, Salt Lake City, Utah, USA.; Pediatric Cardiology, University of Utah School of Medicine and Primary Children's Hospital, Intermountain Healthcare Salt Lake City, Salt Lake City, Utah, USA.; Yost CC; Divisions of Neonatology, University of Utah School of Medicine and Primary Children's Hospital, Intermountain Healthcare Salt Lake City, Salt Lake City, Utah, USA.; Molecular Medicine Program, University of Utah School of Medicine and Primary Children's Hospital, Intermountain Healthcare Salt Lake City, Salt Lake City, Utah, USA.; Yoder BA; Divisions of Neonatology, University of Utah School of Medicine and Primary Children's Hospital, Intermountain Healthcare Salt Lake City, Salt Lake City, Utah, USA.; Yang MJ; Divisions of Neonatology, University of Utah School of Medicine and Primary Children's Hospital, Intermountain Healthcare Salt Lake City, Salt Lake City, Utah, USA, michelle.yang@hsc.utah.edu. |
| Source: | Neonatology [Neonatology] 2025 Dec 22, pp. 1-9. Date of Electronic Publication: 2025 Dec 22. |
| Publication Model: | Ahead of Print |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Karger Country of Publication: Switzerland NLM ID: 101286577 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1661-7819 (Electronic) Linking ISSN: 16617800 NLM ISO Abbreviation: Neonatology Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel : Karger |
| Abstract: | Introduction: The aim of this study was to correlate oxygenation index (OI) and oxygen saturation index (OSI) in congenital diaphragmatic hernia (CDH) and determine the impact of guideline changes from two different epochs.; Methods: Retrospective analysis of 390 CDH neonates managed at University of Utah/Primary Children's Hospitals from 2003 to 2024. We performed regression analysis for paired OI and OSI values over the first week of life (2,604 pairs), comparing pre- (2003-2015) and post- (2016-2024) epoch effects of a 2016 CDH guideline. We analyzed predictive abilities for OI and OSI within and between epochs for extracorporeal membrane oxygenation (ECMO) and/or death.; Results: OI and OSI showed higher correlation in the post- (R2 = 0.755) vs. pre-epoch (R2 = 0.650). Between epochs analysis demonstrated lower inspired oxygen, mean airway pressure, arterial oxygen pressure, OI, and OSI in the post-epoch. ECMO use was lower in post-epoch (9.8% vs. 33%), but pre-ECMO OI and OSI were similar between epochs. Classification of severe lung dysfunction by OI >25 or OSI >12 showed similar abilities to predict ECMO and/or death.; Discussion: OI and OSI were highly correlated in CDH but affected by variation in CDH management. OSI classified severity of cardiopulmonary dysfunction as effectively as OI.; (© 2025 The Author(s). Published by S. Karger AG, Basel.) |
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| Contributed Indexing: | Keywords: Congenital diaphragmatic hernia; Extracorporeal membrane oxygenation; Outcome prediction; Oxygen saturation index; Oxygenation index |
| Entry Date(s): | Date Created: 20251222 Latest Revision: 20260131 |
| Update Code: | 20260131 |
| PubMed Central ID: | PMC12851597 |
| DOI: | 10.1159/000550139 |
| PMID: | 41428592 |
| Database: | MEDLINE |
Journal Article