Human fluoroacetate poisoning: A case series of 36 patients in Vietnam.
| Title: | Human fluoroacetate poisoning: A case series of 36 patients in Vietnam. |
|---|---|
| Authors: | Duc ND; Poison Control Center, Bach Mai Hospital, Hanoi, Viet Nam.; Anh LNH; Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Viet Nam.; Khanh LNH; Vinh University of Medicine and Pharmacy, Nghe An, Viet Nam.; Bach ND; Hanoi Medical University, Hanoi, Viet Nam. |
| Source: | Toxicology reports [Toxicol Rep] 2025 Dec 14; Vol. 16, pp. 102189. Date of Electronic Publication: 2025 Dec 14 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Ireland Ltd Country of Publication: Ireland NLM ID: 101630272 Publication Model: eCollection Cited Medium: Internet ISSN: 2214-7500 (Electronic) Linking ISSN: 22147500 NLM ISO Abbreviation: Toxicol Rep Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Ireland] : Elsevier Ireland Ltd., [2014]- |
| Abstract: | Fluoroacetate poisoning is a rare but potentially lethal condition. We retrospectively reviewed 36 consecutive patients (27 males and 9 females) with confirmed poisoning treated at the Poison Control Center, Bach Mai Hospital, Hanoi, Vietnam, from June 2023 to December 2024. The mean age was 35.4 ± 12.6 years. The median time from ingestion to hospital admission was 3.5 h. On admission, 69.4 % of patients were asymptomatic, 22.2 % had seizures, and 8.3 % presented with altered consciousness. The mean Glasgow Coma Scale (GCS) score was 13.9 ± 2.0 (range 5-15). Median serum creatinine and creatine kinase (CK) levels were 72 µmol/L and 155 U/L, respectively; 16.7 % of patients had CK > 1000 U/L. Median ionized calcium was 1.015 mmol/L, and 19.4 % had serum lactate ≥ 2 mmol/L. Gastric lavage and activated charcoal were administered in 44.4 % and 36.1 % of cases, respectively. Six patients (16.7 %) required intensive care unit (ICU) admission, and no deaths occurred. Overall, most patients presented early with mild manifestations and had favorable short-term outcomes under supportive management.; (© 2025 The Authors.) |
| Competing Interests: | The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Nguyen Dang Duc reports was provided by Bach Mai Hospital. Nguyen dang duc reports a relationship with Bach Mai Hospital that includes: employment. Duc Dang Nguyen has patent N/a pending to N/a. Nguyen Dang Duc, draft and vision this manuscription Lam Nguyen Hong Anh, methods Lam Nguyen Hong Khanh, data Nguyen Dang Duc, software If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
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| Contributed Indexing: | Keywords: Clinical features; Fluoroacetate poisoning; ICU admission; Outcome; Sodium fluoroacetate; Vietnam |
| Entry Date(s): | Date Created: 20260107 Date Completed: 20260107 Latest Revision: 20260109 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12767865 |
| DOI: | 10.1016/j.toxrep.2025.102189 |
| PMID: | 41498051 |
| Database: | MEDLINE |
Journal Article