PRAYAS: individual patient data meta-analysis database for Pooled Research and Analysis for Yielding Anemia-free Solutions in India.
| Title: | PRAYAS: individual patient data meta-analysis database for Pooled Research and Analysis for Yielding Anemia-free Solutions in India. |
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| Authors: | Pandey AK; Department of Health Systems and Implementation Research, International Institute of Health Management Research, New Delhi, India.; Sinha AP; Indian Council for Medical Research, New Delhi, India.; Rawat R; Centre for Public Health Kinetics, New Delhi, India.; Chowdhury R; Society for Applied Studies, New Delhi, India.; Goudar SS; J N Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.; Nagpal J; Sitaram Bhartia Institute of Science and Research New Delhi (SBISR), New Delhi, India.; Desai S; Society for Education, Welfare and Action-Rural, Bharuch, India.; Laxmaiah A; ICMR-National Institute of Nutrition, Hyderabad, India.; Basany K; SHARE India, MediCiti Institute of Medical Sciences, Hyderabad, India.; Joshi S; Interactive Research School for Health Affairs, Bharati Vidyapeeth Deemed to be University, Pune, India.; Yajnik C; KEM Hospital Research Centre, Pune, India.; Mukherjee A; Indian Council for Medical Research, New Delhi, India.; Dwarkanath P; St. John's Research Institute, Bangalore, India.; Bansal PG; Indian Council for Medical Research, New Delhi, India.; Jacob M; Christian Medical College, Vellore, India.; Bhatnagar S; Translational Health Science and Technology Institute, Faridabad, Haryana, India.; Shah K; Indian Institute of Public Health Gandhinagar, Gandhinagar, India.; Mukherjee D; Public Health Foundation of India, Bangalore, India.; Shukla A; Indian Council for Medical Research, New Delhi, India.; Pullakhandam R; ICMR-National Institute of Nutrition, Hyderabad, India.; Dhurde V; Lata Medical Research Foundation, Nagpur, India.; Apte A; Vadu Rural Health Program, KEM Hospital Research Centre, Pune, India.; Singh R; ICMR-Regional Medical Research Centre, Gorakhpur, India.; Gupta A; All India Institute of Medical Sciences, New Delhi, India.; Priyanka Y; Indian Council for Medical Research, New Delhi, India.; Dhingra U; Centre for Public Health Kinetics, New Delhi, India.; Upadhyay RP; Society for Applied Studies, New Delhi, India.; Neogi SB; Department of Health Systems and Implementation Research, International Institute of Health Management Research, New Delhi, India.; Somannavar MS; J N Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.; Mandal A; Sitaram Bhartia Institute of Science and Research New Delhi (SBISR), New Delhi, India.; Desai G; Society for Education, Welfare and Action-Rural, Bharuch, India.; Sengupta S; Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, India.; Dandge S; SHARE India, MediCiti Institute of Medical Sciences, Hyderabad, India.; Wagh G; Bharati Hospital and Research Centre, Pune, India.; Deshmukh U; KEM Hospital Research Centre, Pune, India.; Kumar G; Indian Council for Medical Research, New Delhi, India.; Kurpad AV; St. John's Research Institute, Bangalore, India.; Toteja GS; Indian Council for Medical Research, New Delhi, India.; John NM; Christian Medical College, Vellore, India.; Sopory S; Translational Health Science and Technology Institute, Faridabad, Haryana, India.; Saha S; Indian Institute of Public Health Gandhinagar, Gandhinagar, India.; Babu GR; Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar.; Suryavanshi A; Indian Council for Medical Research, New Delhi, India.; Palika R; ICMR-National Institute of Nutrition, Hyderabad, India.; Patel A; Lata Medical Research Foundation, Nagpur, India.; Nimkar R; Vadu Rural Health Program, KEM Hospital Research Centre, Pune, India.; Dwivedi GR; ICMR-Regional Medical Research Centre, Gorakhpur, India.; Kapil U; All India Institute of Medical Sciences, New Delhi, India.; Raja D; Indian Council for Medical Research, New Delhi, India.; Dutta A; Centre for Public Health Kinetics, New Delhi, India.; Taneja S; Society for Applied Studies, New Delhi, India.; Gautam D; Department of Health Systems and Implementation Research, International Institute of Health Management Research, New Delhi, India.; Kavi A; J N Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.; Rawat S; Sitaram Bhartia Institute of Science and Research New Delhi (SBISR), New Delhi, India.; Dave K; Society for Education, Welfare and Action-Rural, Bharuch, India.; Raman R; Banaras Hindu University (BHU), Varanasi, India.; Haggerty CL; School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.; Lalwani S; Bharati Hospital and Research Centre, Pune, India.; Phadke P; KEM Hospital Research Centre, Pune, India.; Turuk A; Indian Council for Medical Research, New Delhi, India.; Thomas T; St. John's Research Institute, Bangalore, India.; Bhatia N; Lady Irwin College, New Delhi, India.; Beck MM; Christian Medical College, Vellore, India.; Kaur L; Translational Health Science and Technology Institute, Faridabad, Haryana, India.; Shukla A; Indian Institute of Public Health Gandhinagar, Gandhinagar, India.; Deepa R; Public Health Foundation of India, Bangalore, India.; Locks LM; Department of Health Sciences, Boston University, Boston, MA, United States.; Agarwal DM; Vadu Rural Health Program, KEM Hospital Research Centre, Pune, India.; Mamidi RS; ICMR-National Institute of Nutrition, Hyderabad, India.; Sachdev HS; Sitaram Bhartia Institute of Science and Research New Delhi (SBISR), New Delhi, India.; Talukdar R; Ahmedabad University, Ahmedabad, Gujarat, India.; Das S; Centre for Public Health Kinetics, New Delhi, India.; Bhandari N; Society for Applied Studies, New Delhi, India.; Singh R; Indian Institute of Public Health, Delhi, India.; Yogeshkumar S; J N Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.; Yadav R; Sitaram Bhartia Institute of Science and Research New Delhi (SBISR), New Delhi, India.; Reddy PS; School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.; Gupte S; Gupte Hospital and Research Centre, Pune, India.; Ladkat SR; KEM Hospital Research Centre, Pune, India.; Gonmei Z; Indian Council for Medical Research, New Delhi, India.; Rathore S; Christian Medical College, Vellore, India.; Sharma D; Translational Health Science and Technology Institute, Faridabad, Haryana, India.; Pandya A; Indian Institute of Public Health Gandhinagar, Gandhinagar, India.; Ana Y; Public Health Foundation of India, Bangalore, India.; Hibberd P; Boston University School of Medicine, Corsstown, Boston, MA, United States.; Lubree H; Vadu Rural Health Program, KEM Hospital Research Centre, Pune, India.; Dudekula AB; ICMR-National Institute of Nutrition, Hyderabad, India.; Lal PR; All India Institute of Medical Sciences, New Delhi, India.; Khan PA; Indian Council for Medical Research, New Delhi, India.; Verma A; LLRM Medical College, Meerut, Uttar Pradesh, India.; Charantimath US; J N Medical College, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.; Meshram II; ICMR-National Institute of Nutrition, Hyderabad, India.; Randhir K; Interactive Research School for Health Affairs, Bharati Vidyapeeth Deemed to be University, Pune, India.; Deshmukh O; KEM Hospital Research Centre, Pune, India.; Roy AK; Indian Council for Medical Research, New Delhi, India.; John O; Christian Medical College, Vellore, India.; Saldanha ND; Avon and Wiltshire Mental Health Partnership NHS Trust, Bath, United Kingdom.; Bavdekar A; Vadu Rural Health Program, KEM Hospital Research Centre, Pune, India.; Kumar R; BRD Medical College, Gorakhpur, Uttar Pradesh, India.; Prakash S; All India Institute of Medical Sciences, New Delhi, India.; Fawzi WW; BRD Medical College, Gorakhpur, Uttar Pradesh, India.; Sazawal S; Centre for Public Health Kinetics, New Delhi, India. |
| Source: | Frontiers in public health [Front Public Health] 2025 Dec 23; Vol. 13, pp. 1696787. Date of Electronic Publication: 2025 Dec 23 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Lausanne : Frontiers Editorial Office |
| MeSH Terms: | Anemia*/epidemiology ; Anemia*/prevention & control ; Anemia, Iron-Deficiency*/epidemiology ; Anemia, Iron-Deficiency*/prevention & control ; Databases, Factual*; India/epidemiology ; Humans ; Female ; Pregnancy ; Infant ; Adolescent ; Child, Preschool ; Child ; Prevalence ; Infant, Newborn ; Male ; Adult |
| Abstract: | Purpose: The PRAYAS Individual Patient Data Meta-analysis (IPD-MA) database aims to estimate the prevalence of anemia among children under 18 years, non-pregnant and non-lactating (NPNL) women, and pregnant women (by trimester), with further stratification by age group, year, and region of India. Beyond prevalence, it seeks to address the etiological contribution of iron and other erythropoietic micronutrient deficiencies and to evaluate the effectiveness of anemia prevention and treatment interventions, including factors associated with non-response. This will directly support India's "test-treat-track" approach under the Anemia Mukt Bharat program.; Participants: Children (0-18 years), pregnant women, and NPNL women in India.; Findings to Date: The database currently includes 88 datasets (1994-2023), with 319,721 participants for prevalence analysis-children (19,762), NPNL women (17,883), and pregnant women (282,076). Intervention studies comprise 59,292 participants-children (13,435), NPNL women (11,594), and pregnant women (34,263). Over half the datasets (55.7%, 49/88) are randomized controlled trials, while 35.2% (31/88) are observational. Geographically, 43.2% (38/88) are from northern India, 22.7% (20/88) from the west, and 18.2% (16/88) from the south. Most studies (67%, 59/88) are community-based. Median ages were 26 years (IQR 23-32) for NPNL and 23 years (IQR 21-25) for pregnant women, while children's data covered 6 months to 18 years. Mean gestational age at enrollment in pregnancy was 10.24 weeks (SD 17.65). Of the total sample, 10.8% had complete blood count data, 9% ferritin, and 4.5% vitamin B12.Among interventions, pregnant women received intravenous iron sucrose, ferric carboxymaltose, iron isomaltoside, combined IV iron with vitamin B12/folic acid/niacinamide, integrated packages, and low-dose calcium supplementation. NPNL women were often part of trials comparing 60 mg daily ferrous sulfate with 120 mg on alternate days. Children's interventions mainly included ferrous sulfate, food supplementation, and select Ayush-based approaches.; Future Plans: PRAYAS will generate robust, policy-relevant evidence to refine anemia prevention and treatment strategies. Findings will directly inform the Anemia Mukt Bharat program, supporting targeted, evidence-driven interventions to reduce anemia and associated health burdens across children, women, and pregnant populations in India.; Clinical Trial Registration: OSF-https://doi.org/10.17605/OSF.IO/6YRXF.; (Copyright © 2025 Pandey, Sinha, Rawat, Chowdhury, Goudar, Nagpal, Desai, Laxmaiah, Basany, Joshi, Yajnik, Mukherjee, Dwarkanath, Bansal, Jacob, Bhatnagar, Shah, Mukherjee, Shukla, Pullakhandam, Dhurde, Apte, Singh, Gupta, Priyanka, Dhingra, Upadhyay, Neogi, Somannavar, Mandal, Desai, Sengupta, Dandge, Wagh, Deshmukh, Kumar, Kurpad, Toteja, John, Sopory, Saha, Babu, Suryavanshi, Palika, Patel, Nimkar, Dwivedi, Kapil, Raja, Dutta, Taneja, Gautam, Kavi, Rawat, Dave, Raman, Haggerty, Lalwani, Phadke, Turuk, Thomas, Bhatia, Beck, Kaur, Shukla, Deepa, Locks, Agarwal, Mamidi, Sachdev, Talukdar, Das, Bhandari, Singh, Yogeshkumar, Yadav, Reddy, Gupte, Ladkat, Gonmei, Rathore, Sharma, Pandya, Ana, Hibberd, Lubree, Dudekula, Lal, Khan, Verma, Charantimath, Meshram, Randhir, Deshmukh, Roy, John, Saldanha, Bavdekar, Kumar, Prakash, Fawzi and Sazawal.) |
| Competing Interests: | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
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| Contributed Indexing: | Keywords: anemia; intervention; iron-deficiency; public policy and governance; sustainable development goals |
| Entry Date(s): | Date Created: 20260108 Date Completed: 20260108 Latest Revision: 20260110 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12771771 |
| DOI: | 10.3389/fpubh.2025.1696787 |
| PMID: | 41503041 |
| Database: | MEDLINE |
Journal Article