Comparison of Glucose and Glutamine as Energy Substrates for Astrocytes under Conditions of Oxygen Deficiency.
| Title: | Comparison of Glucose and Glutamine as Energy Substrates for Astrocytes under Conditions of Oxygen Deficiency. |
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| Authors: | Turovsky EA; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino Scientific Center for Biological Research, Russian Academy of Sciences, Pushchino, Russia.; Babenko VA; A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.; Varlamova EG; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino Scientific Center for Biological Research, Russian Academy of Sciences, Pushchino, Russia.; Plotnikov EY; A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. plotnikov@belozersky.msu.ru.; Andrianova NV; A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. |
| Source: | Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2025 Sep; Vol. 179 (5), pp. 584-589. Date of Electronic Publication: 2026 Jan 08. |
| Publication Type: | Journal Article; Comparative Study |
| Language: | English |
| Journal Info: | Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York : Springer; Original Publication: New York, Consultants Bureau. |
| MeSH Terms: | Astrocytes*/metabolism ; Astrocytes*/drug effects ; Astrocytes*/cytology ; Glutamine*/metabolism ; Glutamine*/pharmacology ; Glucose*/metabolism ; Glucose*/pharmacology ; Oxygen*/metabolism; Calcium/metabolism ; Oxidative Phosphorylation/drug effects ; Cell Survival/drug effects ; Apoptosis/drug effects ; Animals ; Glycolysis ; Energy Metabolism ; Rats ; Cells, Cultured |
| Abstract: | We studied the effects of glucose and glutamine deficiency on the survival of astrocytes after ischemic injury and examined the mechanisms of cell death. It was found that glutamine can serve as an alternative energy substrate that maintains oxidative phosphorylation and glycolysis in astrocytes. However, the combination of glucose and glutamine reduced the ischemia-induced increase in intracellular calcium and the expression of proapoptotic proteins to a greater extent. The results of the study indicate the possibility of using glutamine to maintain the viability of brain cells under conditions of oxygen and energy substrate deprivation.; (© 2026. Springer Science+Business Media, LLC, part of Springer Nature.) |
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| Contributed Indexing: | Keywords: astrocytes; brain; energy substrates; ischemia; stroke |
| Substance Nomenclature: | 0RH81L854J (Glutamine); IY9XDZ35W2 (Glucose); SY7Q814VUP (Calcium); S88TT14065 (Oxygen) |
| Entry Date(s): | Date Created: 20260108 Date Completed: 20260124 Latest Revision: 20260124 |
| Update Code: | 20260130 |
| DOI: | 10.1007/s10517-026-06530-2 |
| PMID: | 41505045 |
| Database: | MEDLINE |
Journal Article; Comparative Study