The arginase-polyamine signaling axis in immune cells: Implications for immune modulation and host-pathogen interactions.
| Title: | The arginase-polyamine signaling axis in immune cells: Implications for immune modulation and host-pathogen interactions. |
|---|---|
| Authors: | Aziz S; Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana, India.; Graduate Studies, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.; Ahmed A; Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana, India.; Laboratory of Human Immunology, Division of Infectious Diseases, St. John's Research Institute, Bangalore, Karnataka, India.; Singh P; Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana, India.; Mukhopadhyay S; Laboratory of Molecular Cell Biology, BRIC-Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana, India. |
| Source: | IScience [iScience] 2025 Dec 06; Vol. 29 (1), pp. 114363. Date of Electronic Publication: 2025 Dec 06 (Print Publication: 2026). |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Cambridge, MA] : Cell Press, [2018]- |
| Abstract: | The immune system employs complex metabolic pathways to regulate host-pathogen interactions. Among these, the arginase-polyamine axis is a crucial modulator of both innate and adaptive immunity. Despite significant progress, the precise roles and regulatory mechanisms governing the arginase-polyamine axis in immune cell function remain incompletely understood. This review aims to provide a comprehensive analysis of the arginase-polyamine axis, highlighting its role in maintaining immune homeostasis and preserving the functional integrity of various immune cell types. Furthermore, we discuss the strategies used by diverse pathogens to manipulate this pathway, facilitating the creation of immunosuppressive microenvironments that promote their intracellular survival and replication in the host. Finally, we highlight the potential of innovative therapeutic strategies that target arginase-polyamine signaling pathways, which can effectively modulate immune responses in the context of infectious diseases.; (© 2025 The Authors.) |
| Competing Interests: | The authors declare no conflict of interest. |
| References: | PLoS One. 2012;7(3):e34022. (PMID: 22479507); Biochem J. 1996 Jan 15;313 ( Pt 2):549-54. (PMID: 8573091); Mol Microbiol. 2008 Apr;68(1):4-16. (PMID: 18405343); J Biol Chem. 2009 Apr 10;284(15):9899-907. (PMID: 19196710); Nat Immunol. 2001 Oct;2(10):907-16. (PMID: 11577346); Semin Cell Dev Biol. 2023 Sep 15;146:70-79. (PMID: 36604249); Cell. 2021 Aug 5;184(16):4186-4202.e20. (PMID: 34216540); J Immunol. 2001 Dec 1;167(11):6533-44. (PMID: 11714822); Cell. 2016 Oct 20;167(3):829-842.e13. (PMID: 27745970); Sci Signal. 2010 Aug 17;3(135):ra62. (PMID: 20716764); Redox Biol. 2024 Jun;72:103151. (PMID: 38593631); Chem Res Toxicol. 2008 Dec;21(12):2424-32. (PMID: 19548361); PLoS One. 2018 Oct 11;13(10):e0205254. (PMID: 30307989); Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E4024-32. (PMID: 25201986); Pharm Pat Anal. 2014 Jan;3(1):65-85. (PMID: 24354980); Free Radic Biol Med. 2020 Dec;161:339-350. (PMID: 33122005); J Biol Chem. 2004 Jul 30;279(31):32243-51. (PMID: 15166218); Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E75-82. (PMID: 11120661); Cell Death Differ. 2016 Nov 1;23(11):1850-1861. (PMID: 27447115); MAbs. 2020 Jan-Dec;12(1):1801230. (PMID: 32880207); J Eukaryot Microbiol. 2003 Sep-Oct;50(5):312-6. (PMID: 14563168); Shock. 2001 Mar;15(3):215-9. (PMID: 11236905); J Bacteriol. 1999 Dec;181(23):7314-22. (PMID: 10572136); Aging (Albany NY). 2011 Aug;3(8):716-32. (PMID: 21869457); PLoS One. 2013 Jun 03;8(6):e65806. (PMID: 23755283); Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8638-43. (PMID: 11438703); Science. 2001 Jul 20;293(5529):498-506. (PMID: 11463916); Cell Microbiol. 1999 Sep;1(2):143-55. (PMID: 11207548); J Immunol. 2018 May 15;200(10):3587-3598. (PMID: 29669785); Microbiology (Reading). 2010 Apr;156(Pt 4):1144-1154. (PMID: 20035006); Nat Commun. 2021 Mar 5;12(1):1460. (PMID: 33674584); J Immunol. 1999 Oct 1;163(7):3771-7. (PMID: 10490974); Nat Rev Immunol. 2005 Aug;5(8):641-54. (PMID: 16056256); Int Immunopharmacol. 2024 Feb 15;128:111544. (PMID: 38266445); Cell Mol Life Sci. 2001 Aug;58(9):1350-7. (PMID: 11577992); Proc Natl Acad Sci U S A. 1997 May 13;94(10):5243-8. (PMID: 9144222); Pulm Pharmacol Ther. 2001;14(4):297-305. (PMID: 11440558); Int J Med Microbiol. 2013 Dec;303(8):484-91. (PMID: 23871215); J Fungi (Basel). 2018 Jun 08;4(2):. (PMID: 29890663); Elife. 2020 Dec 15;9:. (PMID: 33317695); Immunity. 2007 Sep;27(3):393-405. (PMID: 17892848); Microb Pathog. 2016 Jun;95:117-123. (PMID: 27041598); Amino Acids. 2009 May;37(1):153-68. (PMID: 19030957); Cell Metab. 2019 Aug 6;30(2):352-363.e8. (PMID: 31130465); Infect Immun. 2000 Aug;68(8):4653-7. (PMID: 10899869); Infect Immun. 2013 Oct;81(10):3903-11. (PMID: 23918778); FEMS Immunol Med Microbiol. 2009 Jan;55(1):68-73. (PMID: 19076221); Int J Med Sci. 2025 Mar 10;22(8):1762-1772. (PMID: 40225858); Immunobiology. 2007;212(9-10):795-812. (PMID: 18086380); Am J Physiol. 1997 Dec;273(6):C1882-8. (PMID: 9435493); Infect Immun. 2016 Dec 29;85(1):. (PMID: 27795357); Immunity. 2019 Aug 20;51(2):272-284.e7. (PMID: 31399282); Signal Transduct Target Ther. 2024 Dec 6;9(1):343. (PMID: 39638788); Infect Immun. 2020 Jun 22;88(7):. (PMID: 32312763); Int J Parasitol. 2009 Feb;39(3):267-79. (PMID: 18723022); Antimicrob Agents Chemother. 2009 Dec;53(12):5259-64. (PMID: 19805570); Bioorg Med Chem. 2020 Sep 15;28(18):115658. (PMID: 32828425); Microbiology (Reading). 2011 Feb;157(Pt 2):504-515. (PMID: 20966092); PLoS One. 2007 Dec 12;2(12):e1291. (PMID: 18074016); J Immunol. 2014 Aug 15;193(4):1690-700. (PMID: 25009204); J Immunol. 1999 Aug 1;163(3):1473-80. (PMID: 10415049); Front Cell Infect Microbiol. 2024 Feb 26;14:1342913. (PMID: 38469348); J Allergy Clin Immunol. 2013 Apr;131(4):959-71. (PMID: 23465663); PLoS Pathog. 2016 Apr 04;12(4):e1005494. (PMID: 27043018); J Infect Dis. 2014 Jun 1;209(11):1781-91. (PMID: 24338350); Trends Biochem Sci. 2018 Oct;43(10):752-789. (PMID: 30177408); Cell Mol Life Sci. 1999 Jul;55(8-9):1015-28. (PMID: 10484661); J Immunol. 2006 Oct 15;177(8):5595-603. (PMID: 17015747); Med Res Rev. 2017 May;37(3):475-513. (PMID: 27862081); Mol Microbiol. 2003 Jan;47(2):519-27. (PMID: 12519201); Biochem Soc Trans. 2003 Apr;31(2):415-9. (PMID: 12653650); Front Microbiol. 2022 Nov 18;13:1029966. (PMID: 36466634); Immunity. 2024 Apr 9;57(4):632-648. (PMID: 38599163); AMB Express. 2021 Dec 15;11(1):168. (PMID: 34910273); Trends Immunol. 2004 Dec;25(12):677-86. (PMID: 15530839); Front Immunol. 2014 Oct 27;5:532. (PMID: 25386178); PLoS One. 2024 Aug 7;19(8):e0307573. (PMID: 39110759); J Leukoc Biol. 2002 Jul;72(1):101-6. (PMID: 12101268); Eur J Immunol. 2002 May;32(5):1428-33. (PMID: 11981831); Int J Parasitol. 2002 Jun;32(6):727-37. (PMID: 12062491); Cell Commun Signal. 2023 Dec 4;21(1):348. (PMID: 38049863); PLoS One. 2012;7(4):e36149. (PMID: 22558361); Mol Biochem Parasitol. 2005 Jan;139(1):107-16. (PMID: 15610825); Circ Res. 2011 Aug 19;109(5):492-501. (PMID: 21757649); J Surg Oncol. 2017 Mar;115(3):273-280. (PMID: 27861915); Nat Rev Immunol. 2011 Oct 14;11(11):723-37. (PMID: 21997792); Discov Immunol. 2025 May 15;4(1):kyaf009. (PMID: 40510183); Oncoimmunology. 2017 Apr 20;6(6):e1316437. (PMID: 28680747); Life Sci. 2004 Jun 25;75(6):639-53. (PMID: 15172174); J Exp Med. 2001 Mar 19;193(6):777-84. (PMID: 11257143); J Immunol. 2004 Jul 1;173(1):586-93. (PMID: 15210820); Trends Pharmacol Sci. 2015 Jun;36(6):395-405. (PMID: 25930708); Trop Med Infect Dis. 2024 Jun 06;9(6):. (PMID: 38922041); Biochem J. 2009 Jul 15;421(3):323-38. (PMID: 19589128); PLoS Pathog. 2010 Jun 17;6(6):e1000899. (PMID: 20585552); Surgery. 1988 Aug;104(2):142-51. (PMID: 2840748); IUBMB Life. 2015 Mar;67(3):160-9. (PMID: 25906835); Nature. 1988 Jun 16;333(6174):664-6. (PMID: 3131684); Infect Immun. 2006 Jan;74(1):352-61. (PMID: 16368990); Eur J Immunol. 2014 Jun;44(6):1582-92. (PMID: 24777896); J Biol Chem. 2002 Jun 14;277(24):21123-9. (PMID: 11950832); JCI Insight. 2019 Nov 21;4(24):. (PMID: 31751318); Front Immunol. 2024 Apr 02;15:1363938. (PMID: 38605962); Exp Neurobiol. 2017 Oct;26(5):278-286. (PMID: 29093636); Immunity. 2010 May 28;32(5):593-604. (PMID: 20510870); Res Microbiol. 2016 Jun;167(5):403-12. (PMID: 27068185); J Clin Invest. 2022 Nov 15;132(22):. (PMID: 36377658); Microbes Infect. 2008 Aug-Sep;10(10-11):1166-74. (PMID: 18625332); J Biol Chem. 2016 Jul 15;291(29):14904-12. (PMID: 27268251); PLoS Negl Trop Dis. 2017 Mar 17;11(3):e0005472. (PMID: 28306713); Trans R Soc Trop Med Hyg. 1985;79(5):692-8. (PMID: 3938090); Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6350-5. (PMID: 16601099); Mol Cell. 2019 Oct 3;76(1):110-125.e9. (PMID: 31474573); Cell. 2009 Aug 7;138(3):606.e1-2. (PMID: 19665979); Eukaryot Cell. 2013 Jan;12(1):91-100. (PMID: 23143683); Biosci Biotechnol Biochem. 1998 Dec;62(12):2334-40. (PMID: 9972259); Virol J. 2024 Jan 12;21(1):18. (PMID: 38216935); Front Immunol. 2014 Oct 27;5:533. (PMID: 25386179); Physiol Rev. 2018 Apr 1;98(2):641-665. (PMID: 29412048); Infect Immun. 1999 Sep;67(9):4870-8. (PMID: 10456943); iScience. 2020 Jan 24;23(1):100807. (PMID: 31962236); Lancet. 1991 Mar 16;337(8742):645-6. (PMID: 1671995); Front Microbiol. 2018 Jan 15;8:2682. (PMID: 29379478); Front Immunol. 2018 May 02;9:948. (PMID: 29770139); Gene. 2005 Jun 20;353(1):98-106. (PMID: 15922518); Mol Biochem Parasitol. 2009 May;165(1):48-56. (PMID: 19393161); J Immunol. 2009 May 1;182(9):5259-67. (PMID: 19380772); J Infect Dis. 2008 Jun 15;197(12):1772-82. (PMID: 18473687); Eur J Med Chem. 2018 Mar 10;147:1-6. (PMID: 29421567); J Bacteriol. 2011 Sep;193(17):4346-60. (PMID: 21742865); PLoS Pathog. 2012 Jan;8(1):e1002417. (PMID: 22275864); Int Immunopharmacol. 2023 Mar;116:109739. (PMID: 36706590); Immunity. 2021 Jul 13;54(7):1377-1391. (PMID: 34260886); J Bacteriol. 2009 Nov;191(22):6855-64. (PMID: 19749055); Science. 2018 Jan 26;359(6374):. (PMID: 29371440); Med Sci (Basel). 2022 Jul 15;10(3):. (PMID: 35893120); J Immunol. 2009 Jul 15;183(2):1301-12. (PMID: 19561100); J Proteome Res. 2020 May 1;19(5):2053-2070. (PMID: 32285670); Exp Cell Res. 2001 Apr 15;265(1):174-83. (PMID: 11281655); mBio. 2014 Dec 23;5(6):. (PMID: 25538192); Nat Rev Microbiol. 2011 Jul 11;9(8):604-15. (PMID: 21747391); Crit Care Med. 2004 Oct;32(10):2135-45. (PMID: 15483426); Br J Pharmacol. 2009 Jul;157(6):922-30. (PMID: 19508396); Immunity. 2025 Mar 11;58(3):632-647.e12. (PMID: 40023161); Cell Death Dis. 2016 Aug 11;7(8):e2332. (PMID: 27512953); J Immunol. 2002 May 1;168(9):4692-700. (PMID: 11971019); J Bacteriol. 2025 Feb 20;207(2):e0043924. (PMID: 39882905); J Immunol. 2008 Sep 15;181(6):3733-9. (PMID: 18768823); PLoS Negl Trop Dis. 2017 Oct 26;11(10):e0006025. (PMID: 29073150); Acta Trop. 2014 Jun;134:1-9. (PMID: 24560964); J Comput Aided Mol Des. 2016 Apr;30(4):305-21. (PMID: 26891837); Microorganisms. 2021 Jan 28;9(2):. (PMID: 33525448); PLoS Pathog. 2008 Mar 14;4(3):e1000023. (PMID: 18369473); Sci Rep. 2017 Jan 10;7:39706. (PMID: 28071726); Trends Immunol. 2007 May;28(5):227-33. (PMID: 17403614); PLoS One. 2014 Sep 05;9(9):e106589. (PMID: 25192335); Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13844-9. (PMID: 11717441); Biomolecules. 2020 Mar 25;10(4):. (PMID: 32218236); Nat Immunol. 2008 Dec;9(12):1399-406. (PMID: 18978793); Infect Immun. 2007 Jun;75(6):2802-10. (PMID: 17387163); Microbiol Spectr. 2019 Mar;7(2):. (PMID: 30953429); J Anim Sci Biotechnol. 2019 Sep 10;10:69. (PMID: 31516701); J Biol Chem. 2004 May 28;279(22):23668-78. (PMID: 15023992); mBio. 2017 Jan 24;8(1):. (PMID: 28119468); Cancers (Basel). 2016 Mar 15;8(3):. (PMID: 26999211); Biochem Biophys Res Commun. 1995 Jan 17;206(2):667-73. (PMID: 7530004); Exp Biol Med (Maywood). 2009 Apr;234(4):403-9. (PMID: 19176871); J Immunol. 2011 Mar 15;186(6):3632-41. (PMID: 21296975); Biochem J. 2000 Apr 1;347 Pt 1:297-303. (PMID: 10727431); Aging (Albany NY). 2020 Jun 30;12(13):13716-13739. (PMID: 32603310); J Clin Invest. 2002 Nov;110(10):1539-48. (PMID: 12438451); PLoS One. 2011;6(11):e27226. (PMID: 22102881); Amino Acids. 2007 Aug;33(2):341-50. (PMID: 17476569); Science. 2022 Oct 28;378(6618):eabj3510. (PMID: 36302005); Infect Immun. 2018 Feb 20;86(3):. (PMID: 29203548); J Infect Dis. 2001 Sep 15;184(6):743-53. (PMID: 11517436) |
| Contributed Indexing: | Keywords: Immunology; Microbiology |
| Entry Date(s): | Date Created: 20260114 Date Completed: 20260114 Latest Revision: 20260116 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12794441 |
| DOI: | 10.1016/j.isci.2025.114363 |
| PMID: | 41531738 |
| Database: | MEDLINE |
Journal Article; Review