Genomic epidemiology of dengue virus 2 and 3 reveals repeated introductions and exportations of several lineages in Colombia.
| Title: | Genomic epidemiology of dengue virus 2 and 3 reveals repeated introductions and exportations of several lineages in Colombia. |
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| Authors: | Rivero R; Paul G. Allen School for Global Health, Washington State University, Pullman, WA 99164, USA; Instituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia. Electronic address: ricardo.rivero@wsu.edu.; Tique-Salleg V; Instituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia; Hospital San Jeronimo, Montería 230001, Colombia.; Echeverri-De la Hoz D; Instituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia; Universidad de Santander, Facultad de Ciencias Médicas y de la Salud, Programa de Bacteriología y Laboratorio Clínico, Valledupar, Colombia.; Damodaran L; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Paternina D; Instituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia.; Santos-Vega M; Grupo de Biologia Matematica y Computacional (BIOMAC), Universidad de los Andes, Bogotá D.C. 10587, Colombia.; Torres-Hernández D; Centro de Estudios en Infectologia Pediatrica CEIP, Cali, Colombia.; Davalos D; Centro de Estudios en Infectologia Pediatrica CEIP, Cali, Colombia.; López-Medina E; Centro de Estudios en Infectologia Pediatrica CEIP, Cali, Colombia.; Breban MI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 610101, USA.; Arrieta G; Instituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia; Clínica Salud Social, Sincelejo, Sucre, Colombia.; Miranda J; Instituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia.; Hill V; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 610101, USA.; Grubaugh ND; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 610101, USA.; Mattar S; Instituto de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Montería 230002, Colombia. Electronic address: smattar@correo.unicordoba.edu.co. |
| Source: | Cell reports [Cell Rep] 2026 Jan 27; Vol. 45 (1), pp. 116844. Date of Electronic Publication: 2026 Jan 16. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| MeSH Terms: | Dengue Virus*/genetics ; Dengue Virus*/classification ; Dengue*/epidemiology ; Dengue*/virology ; Dengue*/transmission ; Genome, Viral*/genetics ; Genomics*; Colombia/epidemiology ; Aedes/virology ; Humans ; Phylogeny ; Animals ; Phylogeography |
| Abstract: | Dengue fever, a major mosquito-borne viral disease, is transmitted by Aedes mosquitoes and poses a significant global health burden. Despite extensive research, the spatiotemporal dynamics of dengue virus (DENV) lineages in Colombia remain understudied. Here, we analyze 11,443 complete genome sequences from Colombia and the Americas to map the genomic epidemiology of DENV-2 and DENV-3. Phylogeographic reconstruction revealed multiple independent introductions and exportations of the DENV-2 II and III lineages, as well as the DENV-3 lineage III_C.2, underscoring Colombia's critical role as both a source and a sink of viral traffic within the Americas. Antigenic profiling demonstrated distinct clustering of emergent lineages in antigenic space, consistent with immune-escape-driven turnover. These results highlight the necessity of sustained, high-resolution genomic surveillance to guide targeted public health interventions and mitigate dengue transmission across the region.; (Copyright © 2025 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of interests The authors declare no competing interests. |
| Comments: | Update of: medRxiv. 2025 Nov 03:2025.08.07.25333238. doi: 10.1101/2025.08.07.25333238.. (PMID: 40832412) |
| Contributed Indexing: | Keywords: CP: microbiology; antigenic escape; arboviruses; genomic epidemiology; phylogeography; public health; vector-borne disease |
| Entry Date(s): | Date Created: 20260117 Date Completed: 20260130 Latest Revision: 20260131 |
| Update Code: | 20260131 |
| DOI: | 10.1016/j.celrep.2025.116844 |
| PMID: | 41546866 |
| Database: | MEDLINE |
Journal Article