Rice Bran Supplements the Nutritional Density of Ready-to-Use Therapeutic Foods: A Targeted Nutrient and Non-Targeted Metabolomic Analysis.
| Title: | Rice Bran Supplements the Nutritional Density of Ready-to-Use Therapeutic Foods: A Targeted Nutrient and Non-Targeted Metabolomic Analysis. |
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| Authors: | Weber AM; Department of Food Science and Human Nutrition Colorado State University Fort Collins Colorado USA.; Bovaird ES; Department of Biochemistry and Molecular Biology Colorado State University Fort Collins Colorado USA.; Toulabi SB; Department of Horticultural Science Colorado State University Fort Collins Colorado USA.; Barbazza S; Department of Health Sciences, Faculty of Science Vrije Universiteit Amsterdam Amsterdam the Netherlands.; Fauzi MD; Department of Health Sciences, Faculty of Science Vrije Universiteit Amsterdam Amsterdam the Netherlands.; UMR Qualisud, Université Montpellier, CIRAD, Institut Agro, IRD Université Avignon, Université de la Réunion Montpellier France.; Child Health Department of Mohammad Hoesin Hospital Palembang South Sumatera Indonesia.; Child Health Department of Faculty of Medicine Sriwijaya University Palembang South Sumatera Indonesia.; Putri FK; Savica Consultancy Surabaya Jawa Timur Indonesia.; Fadly K; Department of Community Nutrition IPB University Bogor Jawa Barat Indonesia.; South East Asia Food and Agriculture Science and Technology (SEAFAST) Center LRI PGK IPB University Bogor Indonesia.; Tamimi K; Department of Community Nutrition IPB University Bogor Jawa Barat Indonesia.; South East Asia Food and Agriculture Science and Technology (SEAFAST) Center LRI PGK IPB University Bogor Indonesia.; Calvimontes DM; Center for Human Development, Fundación Para la Salud Integral de los Guatemaltecos FUNSALUD Coatepeque Quetzaltenango Guatemala.; Department of Pediatrics, Center for Global Health University of Colorado Aurora Colorado USA.; Rimbawan R; Department of Community Nutrition IPB University Bogor Jawa Barat Indonesia.; South East Asia Food and Agriculture Science and Technology (SEAFAST) Center LRI PGK IPB University Bogor Indonesia.; Nasution Z; Department of Community Nutrition IPB University Bogor Jawa Barat Indonesia.; South East Asia Food and Agriculture Science and Technology (SEAFAST) Center LRI PGK IPB University Bogor Indonesia.; Giriwono PE; South East Asia Food and Agriculture Science and Technology (SEAFAST) Center LRI PGK IPB University Bogor Indonesia.; Department of Food Science and Technology IPB University Bogor Jawa Barat Indonesia.; Wieringa FT; UMR Qualisud, Université Montpellier, CIRAD, Institut Agro, IRD Université Avignon, Université de la Réunion Montpellier France.; French National Research Institute for Sustainable Development (IRD) Montpellier France.; Ryan EP; Department of Environmental and Radiological Health Sciences Colorado State University Fort Collins Colorado USA. |
| Source: | Food science & nutrition [Food Sci Nutr] 2026 Jan 21; Vol. 14 (1), pp. e71448. Date of Electronic Publication: 2026 Jan 21 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101605473 Publication Model: eCollection Cited Medium: Print ISSN: 2048-7177 (Print) Linking ISSN: 20487177 NLM ISO Abbreviation: Food Sci Nutr Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Malden, MA : John Wiley & Sons, [2012]- |
| Abstract: | The treatment of uncomplicated severe acute malnutrition includes ready-to-use therapeutic foods (RUTFs). Novel RUTF recipes aim for inclusion of locally sourced nutrient-dense food ingredients for sustainability in product availability. This study investigated the incorporation of rice bran into RUTF formulations to enhance the bioactive nutrient profile. Experimental RUTFs were developed containing 0%, 5%, 7.5%, and 10% rice bran, without a vitamin/mineral premix for targeted nutrient and non-targeted metabolite analysis. Additionally, an investigation was conducted analyzing the nutrient density and food safety of small-scale mill-sourced rice bran varieties collected from Guatemala and Cambodia for comparison to a US-commercial rice bran. Targeted nutrient composition analysis of the RUTFs revealed dietary fiber, vitamin E, and vitamin B1 generally increased with higher rice bran content, though it was not dose dependent. The non-targeted metabolite analysis identified 883 biochemicals across the four experimental RUTFs. Significant metabolite fold changes were identified for a variety of lipids, amino acids, carbohydrates, vitamins, and xenobiotics in 5%, 7.5%, and 10% rice bran-RUTFs compared to the 0%. Analysis of small-scale mill-sourced rice brans from Guatemala and Cambodia showed variation in vitamin composition, with vitamin B3 averaging 37.1 mg/100 g and vitamin E ranging from 3.2 to 6.0 mg/100 g. These varieties also demonstrated variable microbial levels and trace metal contents, warranting continuous monitoring and evaluation in global supply chains. These findings support the feasibility of incorporating rice bran into RUTFs for malnutrition treatment and the benefit of screening locally sourced rice bran to address regional nutrient-dense food product development and specifically for malnutrition treatment.; (© 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC.) |
| Competing Interests: | The authors declare no conflicts of interest. |
| References: | Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1876-E1885. (PMID: 29432159); Proc Nutr Soc. 1987 Feb;46(1):53-68. (PMID: 3575323); Nat Food. 2023 May;4(5):366-371. (PMID: 37169820); Front Nutr. 2018 Jan 19;4:71. (PMID: 29404331); BMJ Open. 2023 Nov 24;13(11):e076805. (PMID: 38000818); Nutrients. 2022 Mar 25;14(7):. (PMID: 35405992); Nutr Rev. 2025 Apr 01;83(4):692-712. (PMID: 39657228); Nutrients. 2023 May 28;15(11):. (PMID: 37299466); Benef Microbes. 2019 Dec 9;10(8):823-839. (PMID: 31965839); Rice (N Y). 2017 Dec;10(1):24. (PMID: 28547736); Environ Pollut. 2021 Dec 1;290:117962. (PMID: 34418860); Sci Rep. 2021 Jun 15;11(1):12582. (PMID: 34131186); Metabolites. 2018 Oct 09;8(4):. (PMID: 30304872); Nutrients. 2024 Dec 30;17(1):. (PMID: 39796546); Clin Vaccine Immunol. 2014 Oct;21(10):1396-403. (PMID: 25080551); Heliyon. 2023 Nov 19;9(12):e22478. (PMID: 38046154); EBioMedicine. 2024 Jun;104:105166. (PMID: 38833839); PLoS Negl Trop Dis. 2015 Mar 17;9(3):e0003581. (PMID: 25781926); Nutr Rev. 2025 Aug 13;:. (PMID: 40802591); J Agric Food Chem. 2022 Nov 16;70(45):14531-14543. (PMID: 36318603); Nutrients. 2016 Jan 20;8(1):. (PMID: 26805875); PLoS Negl Trop Dis. 2017 Sep 5;11(9):e0005814. (PMID: 28873391); J Sci Food Agric. 2014 Jul;94(9):1808-15. (PMID: 24282164); Biochem Pharmacol. 1997 Nov 1;54(9):1047-53. (PMID: 9374426); Foods. 2021 Dec 05;10(12):. (PMID: 34945564); J Nutr. 2016 Dec;146(12):2436-2444. (PMID: 27807038); Food Nutr Bull. 2009 Sep;30(3 Suppl):S267-342. (PMID: 19998863); J Nutr Biochem. 2020 Feb;76:108303. (PMID: 31812909); Nutrients. 2018 Jul 16;10(7):. (PMID: 30012981); Nat Metab. 2024 Mar;6(3):433-447. (PMID: 38504132); Cell Rep Med. 2021 May 18;2(5):100280. (PMID: 34095882); J Nutr. 2022 Jul 6;152(7):1792-1800. (PMID: 35441218); J Med Food. 2012 May;15(5):469-75. (PMID: 22248178); Cell Death Dis. 2023 Oct 28;14(10):707. (PMID: 37898661); Matern Child Nutr. 2025 Oct;21(4):e70035. (PMID: 40418157); Compr Rev Food Sci Food Saf. 2019 Mar;18(2):441-454. (PMID: 33336939); Food Chem. 2024 Dec 1;460(Pt 1):140479. (PMID: 39053271); Am J Clin Nutr. 2017 Oct;106(4):1100-1112. (PMID: 28814393); Front Microbiol. 2016 Nov 02;7:1699. (PMID: 27853451); Glycobiology. 2023 May 17;33(4):274-288. (PMID: 36795047); Food Sci Nutr. 2021 Jul 19;9(9):5131-5138. (PMID: 34532022); Imeta. 2025 May 29;4(3):e70051. (PMID: 40469518); Sci Rep. 2015 Oct 13;5:15004. (PMID: 26459937); Nutrients. 2023 Jul 17;15(14):. (PMID: 37513584); Antioxidants (Basel). 2023 Aug 25;12(9):. (PMID: 37759973); Nutrients. 2022 Jan 30;14(3):. (PMID: 35276967); BMC Pediatr. 2022 Jul 1;22(1):385. (PMID: 35778675); BMC Microbiol. 2012 Jul 04;12:71. (PMID: 22583915); Pharmacology. 2020;105(5-6):289-299. (PMID: 31630147); Eur J Pharmacol. 2002 Jun 28;447(1):1-9. (PMID: 12106797); Food Funct. 2019 May 22;10(5):2382-2389. (PMID: 30950464); Scand J Gastroenterol. 2011 Jan;46(1):40-52. (PMID: 20735154); Nutrients. 2024 Mar 15;16(6):. (PMID: 38542762); Appl Microbiol Biotechnol. 2020 Sep;104(17):7225-7237. (PMID: 32638045); Mol Nutr Food Res. 2023 Mar;67(6):e2200111. (PMID: 36461912); Sci Rep. 2019 Sep 26;9(1):13919. (PMID: 31558739) |
| Entry Date(s): | Date Created: 20260126 Date Completed: 20260126 Latest Revision: 20260128 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12824455 |
| DOI: | 10.1002/fsn3.71448 |
| PMID: | 41583016 |
| Database: | MEDLINE |
Journal Article