Cannabidiol against Epilepsy: Insights and an Experimental In Silico Approach.
| Title: | Cannabidiol against Epilepsy: Insights and an Experimental In Silico Approach. |
|---|---|
| Authors: | Dos Santos AMF; Postgraduate Program in Pharmaceutical Sciences, Faculty of Health Sciences, University of Brasília, 70910-900, North Wing, Brasília, Distrito Federal, Brazi.; Value in Health Lab, Faculty of Health Sciences, University of Brasília, Brasília, Distrito Federal, Brazil.; da Silva PR; Postgraduate Program of Dentistry (PPGO), Health Sciences Center, Federal University of Paraíba, 58051-900, João Pessoa-PB, Brazil.; Laboratory of Psychopharmacology, Federal University of Paraíba, João Pessoa, Brazil.; Alves AF; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.; Postgraduate Program of Natural and Synthetic Bioactive Products (PPgPNSB), Health Sciences Center, Federal University of Paraíba, João Pessoa, PB 58051-085, Brazil.; Rodrigues TCML; Department of Chemistry, University of Connecticut, Storrs 06269, United States.; Ribeiro LR; Laboratory of Experimental Neurology, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazi.; Pharmacology Postgraduate Program, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil.; Pires HFO; Psychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.; Dias AL; Psychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.; Gomes JS; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazi.; de Andrade JC; Psychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.; Academic League of Medicinal Chemistry, Department of Pharmacy, Uninassau University Center, 58410-022, Santa Luzia S/N, Campina Grande, Paraiba, Brazil.; Souza LRP; Psychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazi.; Neri LCD; Center of Health Sciences, Federal University of Paraíba, João Pessoa-PB, Brazi.; Capucho HC; Laboratory of Psychopharmacology, Federal University of Paraíba, João Pessoa, Brazi.; da Silva Stiebbe Salvadori MG; Laboratory of Psychopharmacology, Federal University of Paraíba, João Pessoa, Brazi.; Department of Psychology, Federal University of Paraíba, João Pessoa, Brazil.; Institute of Research in Pharmaceuticals and Medicines, Federal University of Paraíba, João Pessoa, Brazil.; Felipe CFB; Postgraduate Program of Natural and Synthetic Bioactive Products (PPgPNSB), Health Sciences Center, Federal University of Paraíba, João Pessoa, PB 58051-085, Brazil.; Laboratory of Psychopharmacology, Federal University of Paraíba, João Pessoa, Brazil.; Scotti MT; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.; Postgraduate Program of Natural and Synthetic Bioactive Products (PPgPNSB), Health Sciences Center, Federal University of Paraíba, João Pessoa, PB 58051-085, Brazil.; Scotti L; Cheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.; Teaching and Research Management, University Hospital Lauro Wanderley, Federal University of Paraíba, 58050-585, João Pessoa, PB, Brazil.; Nayarisseri A; Principal Scientist, CEO and Founder of Eminent Biosciences, Indore. |
| Source: | Current pharmaceutical design [Curr Pharm Des] 2026 Jan 22. Date of Electronic Publication: 2026 Jan 22. |
| Publication Model: | Ahead of Print |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9602487 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4286 (Electronic) Linking ISSN: 13816128 NLM ISO Abbreviation: Curr Pharm Des Subsets: MEDLINE |
| Imprint Name(s): | Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers; Original Publication: Schiphol, The Netherlands : Bentham Science Publishers, c1995- |
| Abstract: | Cannabidiol (CBD), one of the compounds found in cannabis sativa, has drawn a lot of interest in the study and treatment of epilepsy. The antiepileptic qualities of CBD are being investigated for their ability to reduce seizure frequency and intensity in people with rare epilepsies, including West syndrome, Ohtahara's syndrome, Dravet syndrome, Lennox-Gastaut syndrome, and Tuberous Sclerosis. This review attempts to analyze the antiepileptic effects of cannabidiol against voltage-gated calcium channel T-type (CaV), GammaAminobutyric Acid A (GABAA), voltage-gated potassium channel of the Q family (KCNQ2), voltage-gated sodium channel (NaV), and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) using in silico techniques. Studies were conducted to investigate Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) parameters, and subsequently, molecular docking was performed. CBD demonstrated good oral absorption and the ability to cross the blood-brain barrier, as indicated by its pharmacokinetic parameters. The CBD may lead to potential drug interactions and increased bioavailability of the molecule due to metabolic interactions with the cytochrome P450 enzymatic system. CBD did not present toxicity parameters evaluated in this work. The molecular docking of CBD showed good interactions with NMDA and Nav. It also demonstrated good binding energy.; (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| Contributed Indexing: | Keywords: AMPA; Epileptic syndromes; GABAA; KCNQ2.; NaV; cannabidiol; molecular docking |
| Entry Date(s): | Date Created: 20260127 Latest Revision: 20260127 |
| Update Code: | 20260130 |
| DOI: | 10.2174/0113816128392406251110112113 |
| PMID: | 41588977 |
| Database: | MEDLINE |
Journal Article