Understanding delayed-onset inflammatory responses (DIRs) to hyaluronic acid fillers: a comprehensive literature review and retrospective cohort study.
| Title: | Understanding delayed-onset inflammatory responses (DIRs) to hyaluronic acid fillers: a comprehensive literature review and retrospective cohort study. |
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| Authors: | Akyol ME; Department of Dermatology, AmsterdamUMC, location AMC, Amsterdam, The Netherlands.; Rustemeyer T; Department of Dermatology, AmsterdamUMC, location AMC, Amsterdam, The Netherlands.; Decates T; Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands. |
| Source: | Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology [J Cosmet Laser Ther] 2025 Dec; Vol. 27 (6-8), pp. 233-245. Date of Electronic Publication: 2026 Jan 27. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136419 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4180 (Electronic) Linking ISSN: 14764172 NLM ISO Abbreviation: J Cosmet Laser Ther Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Informa Healthcare; Original Publication: London : Martin Dunitz, c2001- |
| MeSH Terms: | Hyaluronic Acid*/adverse effects ; Hyaluronic Acid*/administration & dosage ; Dermal Fillers*/adverse effects ; Dermal Fillers*/administration & dosage ; Cosmetic Techniques*/adverse effects ; Inflammation*/chemically induced; Humans ; Retrospective Studies |
| Abstract: | This study aims to investigate the underlying mechanisms and triggers of delayed-onset inflammatory responses DIRs after hyaluronic acid (HA) fillers injections. The literature review included articles on DIRs following HA filler treatments and identified immunological triggers, bacterial contamination, and filler degradation as key factors contributing to DIRs. Additionally, patient data were analyzed from patients treated for DIRs and showed possible immune activation events prior to DIRs included flu-like symptoms. This study underscores the complexity of DIRs following HA filler treatments and the need for transparency from manufacturers. Comprehensive ingredient data are crucial to better understand DIRs and ensure patient safety. |
| Contributed Indexing: | Keywords: Filler; complication; complications; delayed-onset inflammatory responses; fillers; hyaluronic acid |
| Substance Nomenclature: | 9004-61-9 (Hyaluronic Acid); 0 (Dermal Fillers) |
| Entry Date(s): | Date Created: 20260127 Date Completed: 20260517 Latest Revision: 20260517 |
| Update Code: | 20260518 |
| DOI: | 10.1080/14764172.2026.2617549 |
| PMID: | 41591286 |
| Database: | MEDLINE |
Journal Article; Review