Potential of gold nanoparticles in nucleic acid amplification: from amplification enhancement to product detection.
| Title: | Potential of gold nanoparticles in nucleic acid amplification: from amplification enhancement to product detection. |
|---|---|
| Authors: | Phuong NTT; Nguyen Tat Thanh University Center for Hi-Tech Development, Saigon Hi-Tech Park, Ho Chi Minh City 70000, Vietnam.; NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 70000, Vietnam.; Chae WR; Department of BioNano Technology, Gachon University 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 13120, Korea.; Nguyen HA; Department of Molecular Biology, Institute of Food and Biotechnology, Can Tho University, Can Tho City, Vietnam.; Vu TH; Advanced Materials Technology Institute Vietnam National University Ho Chi Minh City, Ho Chi Minh City 70000, Vietnam. tktloan@inomar.edu.vn.; Vietnam National University, Ho Chi Minh City 70000, Vietnam.; Trinh TND; BioTechnology Institute, Tra Vinh University, Tra Vinh City, 87000, Vietnam. ttndiep@tvu.edu.vn.; Trinh KTL; Advanced Materials Technology Institute Vietnam National University Ho Chi Minh City, Ho Chi Minh City 70000, Vietnam. tktloan@inomar.edu.vn.; Vietnam National University, Ho Chi Minh City 70000, Vietnam. |
| Source: | Nanoscale [Nanoscale] 2026 Mar 02; Vol. 18 (8), pp. 4045-4063. Date of Electronic Publication: 2026 Mar 02. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: RSC Pub Country of Publication: England NLM ID: 101525249 Publication Model: Electronic Cited Medium: Internet ISSN: 2040-3372 (Electronic) Linking ISSN: 20403364 NLM ISO Abbreviation: Nanoscale Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge, UK : RSC Pub. |
| MeSH Terms: | Gold*/chemistry ; Metal Nanoparticles*/chemistry ; Nucleic Acid Amplification Techniques*/methods ; Nucleic Acids*/analysis ; Nucleic Acids*/chemistry; Humans |
| Abstract: | Nucleic acid-based detection has been considered one of the most useful tools for diagnosis for several decades, owing to its ability to amplify signals and precisely recognize targets. With increasing demand to rapidly acquire the answer, diagnose early for a better prognosis, detect rare cells, and gain accurate answers, gold nanoparticles (AuNPs) have received growing attention as an excellent additive to fulfill these requirements. Based on a great deal of research, it became clear that AuNPs present an astonishing capacity to boost nucleic acid-based detection performance by exploiting their unique optical, structural, electrical, and thermal properties. In this review, we introduce various methods to synthesize AuNPs, including green synthesis, and broadly cover AuNPs' applications in different aspects, mainly for photothermal heating, enhancing amplification performance, and detection. The significance and basic mechanisms of each category were described using relevant recent articles to guide the planning of an efficient nucleic acid detection strategy for broad users. |
| Substance Nomenclature: | 7440-57-5 (Gold); 0 (Nucleic Acids) |
| Entry Date(s): | Date Created: 20260130 Date Completed: 20260306 Latest Revision: 20260306 |
| Update Code: | 20260307 |
| DOI: | 10.1039/d5nr02578h |
| PMID: | 41614272 |
| Database: | MEDLINE |
Journal Article; Review