C-Reactive Protein for Pulmonary Tuberculosis Screening and Treatment Response Monitoring in Children.
| Title: | C-Reactive Protein for Pulmonary Tuberculosis Screening and Treatment Response Monitoring in Children. |
|---|---|
| Authors: | Githua J; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; Department of Medical Microbiology and Immunology, University of Nairobi, Nairobi, Kenya.; Mecha J; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; Department of Mathematics, University of Nairobi, Nairobi, Kenya.; Stern J; Department of Global Health, University of Washington, Seattle, Washington, USA.; Escudero JN; Department of Global Health, University of Washington, Seattle, Washington, USA.; Njagi L; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; Kijaro L; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; Mirera J; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; Murithi W; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; John-Stewart G; Department of Global Health, University of Washington, Seattle, Washington, USA.; Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; Department of Pediatrics, University of Washington, Seattle, Washington, USA.; Maleche-Obimbo E; Department of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.; Department of Pediatrics, Kenyatta National Hospital, Nairobi, Kenya.; Nduba V; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; LaCourse SM; Department of Global Health, University of Washington, Seattle, Washington, USA.; Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA. |
| Source: | Open forum infectious diseases [Open Forum Infect Dis] 2026 Jan 07; Vol. 13 (2), pp. ofaf816. Date of Electronic Publication: 2026 Jan 07 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]- |
| Abstract: | C-reactive protein (CRP) was evaluated as a biomarker for pulmonary tuberculosis (TB) diagnosis and treatment response monitoring in 292 Kenyan children. Although diagnostic sensitivity was suboptimal (35.5%-50.0%), the median CRP level decreased during TB treatment in children with confirmed (P = .02) or unconfirmed (P < .001) TB, primarily among those with baseline CRP elevation ≥5 mg/L (40% [39 of 97]).; (© The Author(s) 2026. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
| Competing Interests: | Potential conflicts of interest. All authors: No reported conflicts. |
| Comments: | Update of: medRxiv. 2025 Apr 25:2025.04.24.25326338. doi: 10.1101/2025.04.24.25326338.. (PMID: 40313307) |
| References: | J Clin Microbiol. 2022 Feb 16;60(2):e0185921. (PMID: 34911364); Open Forum Infect Dis. 2018 Oct 10;5(11):ofy253. (PMID: 30474046); Lancet Glob Health. 2017 Sep;5(9):e898-e906. (PMID: 28807188); J Pediatric Infect Dis Soc. 2022 Jul 21;11(7):316-321. (PMID: 35451001); Clin Infect Dis. 2015 Oct 15;61Suppl 3:S179-87. (PMID: 26409281); BMC Infect Dis. 2014;14 Suppl 1:S5. (PMID: 24564453); Lancet Infect Dis. 2022 Apr;22(4):507-518. (PMID: 34800394); Lancet Infect Dis. 2017 Dec;17(12):1285-1292. (PMID: 28847636) |
| Grant Information: | R01 AI179714 United States AI NIAID NIH HHS |
| Contributed Indexing: | Keywords: C-reactive protein; diagnosis; pediatric; treatment response; tuberculosis |
| Entry Date(s): | Date Created: 20260209 Date Completed: 20260209 Latest Revision: 20260401 |
| Update Code: | 20260401 |
| PubMed Central ID: | PMC12872367 |
| DOI: | 10.1093/ofid/ofaf816 |
| PMID: | 41660661 |
| Database: | MEDLINE |
Journal Article