Distinct associations between body mass index and polyunsaturated fatty acids in dementia with Lewy Bodies and Alzheimer's disease.
| Title: | Distinct associations between body mass index and polyunsaturated fatty acids in dementia with Lewy Bodies and Alzheimer's disease. |
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| Authors: | Castellanos-Perilla N; Department of Clinical Medicine, University of Bergen, Bergen, Norway; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. Electronic address: nicolas.castellanos.perilla@sus.no.; Borda MG; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway; Department of Neurology, Clínica Universidad de Navarra, Pamplona, Spain.; Chong JR; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Memory, Aging and Cognition Centre, National University Health Systems, Singapore, Singapore; Centre for Healthy Brain Ageing, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; Tovar-Rios DA; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway; L-BioStat, KU Leuven, Leuven, Belgium; Grupo de Investigación en Estadística Aplicada - INFERIR, Facultad de Ingeniería, Universidad del Valle, Santiago de Cali, Valle del Cauca, Colombia; Prevención y Control de la Enfermedad Crónica - PRECEC, Facultad de Salud, Universidad del Valle, Santiago de Cali, Valle del Cauca, Colombia.; Jaramillo-Jimenez A; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway; Grupo de Neurociencias de Antioquia (GNA), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.; Berge RK; Department of Clinical Science, University of Bergen, Bergen, Norway.; Barreto GE; Department of Biological Sciences, University of Limerick, Limerick, Ireland.; Aarsland D; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway; Centre for Healthy Brain Ageing, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.; Vik-M AO; Department of Clinical Medicine, University of Bergen, Bergen, Norway; Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger, Norway. |
| Source: | The journal of nutrition, health & aging [J Nutr Health Aging] 2026 Apr; Vol. 30 (4), pp. 100810. Date of Electronic Publication: 2026 Feb 21. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Masson SAS on behalf of SERDI Publisher Country of Publication: France NLM ID: 100893366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1760-4788 (Electronic) Linking ISSN: 12797707 NLM ISO Abbreviation: J Nutr Health Aging Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : [Paris, France] : Elsevier Masson SAS on behalf of SERDI Publisher; Original Publication: Paris, France : New York, NY : Serdi Publisher ; Springer Pub. Co. |
| MeSH Terms: | Alzheimer Disease*/blood ; Alzheimer Disease*/metabolism ; Lewy Body Disease*/blood ; Lewy Body Disease*/metabolism ; Fatty Acids, Unsaturated*/blood ; Body Mass Index*; Fatty Acids, Omega-6/blood ; Fatty Acid Desaturases/blood ; Fatty Acid Desaturases/metabolism ; Humans ; Male ; Female ; Aged ; Cross-Sectional Studies ; Aged, 80 and over ; Norway ; Cohort Studies ; Fatty Acid Elongases |
| Abstract: | Objective: We aimed to assess the association between body mass index and polyunsaturated fatty acids to determine potential links and metabolic differences between Alzheimer's disease and dementia with Lewy bodies.; Methods: We performed a cross-sectional study of enrolment data with 133 patients with mild AD (n = 75) and DLB (n = 58) from a Norwegian cohort study. We used linear regression models adjusting for age, sex, and diagnosis to explore the association between PUFA concentrations and BMI estimates.; Results: In DLB patients, BMI was positively associated with downstream omega-6 PUFA, including gamma-linolenic acid (GLA; β = 0.285, p = 0.012), arachidonic acid (AA; β = 0.320, p = 0.005), and adrenic acid (β = 0.303, p = 0.005). BMI was also related to increased Δ6-desaturase n-6 activity (β = 0.383, p = 0.002) and Δ6-desaturase n-3 activity (β = 0.335, p = 0.011), along with reduced elongase n-6 (β = -0.396, p = 0.002) and elongase n-3 (β = -0.376, p = 0.004), suggesting increased fatty acid turnover. No significant associations were found in the AD group.; Conclusions: BMI in DLB patients was positively associated with elevated downstream omega-6 metabolites and desaturase and elongase activity, compatible with higher fatty‑acid turnover and systemic inflammatory state hypothesized in DLB. These findings highlight the distinct metabolic alterations across dementia subtypes that are relevant for personalized nutritional strategies in dementia care.; (Copyright © 2026 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.) |
| Contributed Indexing: | Keywords: Dementia; neurodegenerative diseases; nutrition; polyunsaturated fatty acids |
| Substance Nomenclature: | 0 (Fatty Acids, Unsaturated); 0 (Fatty Acids, Omega-6); EC 1.14.19.- (Fatty Acid Desaturases); EC 2.3.1.- (Fatty Acid Elongases) |
| Entry Date(s): | Date Created: 20260222 Date Completed: 20260409 Latest Revision: 20260409 |
| Update Code: | 20260410 |
| PubMed Central ID: | PMC12945632 |
| DOI: | 10.1016/j.jnha.2026.100810 |
| PMID: | 41723910 |
| Database: | MEDLINE |
Journal Article