Optical Coherence Tomography Angiography Characterization of Vascular Alterations in Macular Telangiectasia Type 2.
| Title: | Optical Coherence Tomography Angiography Characterization of Vascular Alterations in Macular Telangiectasia Type 2. |
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| Authors: | Stettler I; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Romano F; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Ding X; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Garg I; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Hoyek S; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Overbey KM; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Bennett C; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Vingopoulos F; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Finn M; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Garcia M; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Rodriguez J; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Baldwin G; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Ploumi I; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Laìns I; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Patel NA; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Wu DM; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Kim LA; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Husain D; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Vavvas DG; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Miller JW; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States.; Miller JB; Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States.; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, United States. |
| Source: | Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2026 Feb 02; Vol. 67 (2), pp. 44. |
| Publication Type: | Journal Article; Observational Study |
| Language: | English |
| Journal Info: | Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: Brookline Ma : Association For Research In Vision And Ophthalmology (Arvo); Original Publication: St. Louis, Mosby. |
| MeSH Terms: | Tomography, Optical Coherence*/methods ; Fluorescein Angiography*/methods ; Retinal Vessels*/pathology ; Retinal Vessels*/diagnostic imaging ; Retinal Telangiectasis*/diagnosis ; Retinal Telangiectasis*/classification ; Retinal Telangiectasis*/diagnostic imaging ; Retinal Telangiectasis*/physiopathology ; Choroid*/blood supply ; Macula Lutea*/blood supply; Humans ; Cross-Sectional Studies ; Female ; Male ; Middle Aged ; Aged ; Fundus Oculi ; Visual Acuity ; Adult |
| Abstract: | Purpose: To investigate retinal microvascular and choriocapillaris changes across the newly proposed seven-step classification for macular telangiectasia type 2 (MacTel) using swept-source optical coherence tomography angiography (SS-OCTA).; Methods: Cross-sectional, observational study including 111 eyes with MacTel (56 patients) and 120 matched control eyes (60 subjects). Participants underwent comprehensive ophthalmic examinations, including macular 6 × 6-mm SS-OCTA. MacTel eyes were categorized into one of seven grades (0-6) using multimodal imaging. SS-OCTA scans were processed to measure vessel density (VD), vessel skeletonized density (VSD), foveal avascular zone (FAZ) metrics, and choriocapillaris flow deficit percentage (CCFD%). Differences between groups were assessed using Mann-Whitney U, Kruskal-Wallis tests, and generalized mixed-effects models. Cluster analysis assessed the agreement between clinical grades and OCTA-based clusters.; Results: Of the MacTel eyes, 32% were grade 0, 9% grade 1, 18% grade 2, 5% grade 3, 15% grade 4, 13% grade 5, and 8% grade 6. MacTel eyes exhibited significant alterations in VD and VSD, particularly in the central 1-mm circle and temporal/inferior sectors, alongside consistently higher CCFD% across all macular regions. Advanced grades (5-6) showed pronounced differences in VD, VSD, and CCFD% compared to early grades (0-2). Agreement between MacTel grading and OCTA-based clusters was fair to moderate (Adjusted Rand Index = 0.233), with higher concordance for grades 0 and 4 to 6.; Conclusions: SS-OCTA reveals significant retinal vascular and choriocapillaris impairment in MacTel, with pronounced alterations in advanced disease grades. The observed vascular damage, extending beyond the MacTel area, underscores the value of OCTA in identifying disease severity and aiding in its classification. |
| Entry Date(s): | Date Created: 20260223 Date Completed: 20260223 Latest Revision: 20260227 |
| Update Code: | 20260227 |
| PubMed Central ID: | PMC12934530 |
| DOI: | 10.1167/iovs.67.2.44 |
| PMID: | 41729044 |
| Database: | MEDLINE |
Journal Article; Observational Study