Prevalence, Antimicrobial Resistance Profiles, and Molecular Characteristics of Methicillin-Resistant Staphylococcus aureus Among School Children in Nha Trang, Central Vietnam.
| Title: | Prevalence, Antimicrobial Resistance Profiles, and Molecular Characteristics of Methicillin-Resistant Staphylococcus aureus Among School Children in Nha Trang, Central Vietnam. |
|---|---|
| Authors: | Omae SA; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.; Center for Microbiology Research, Kenya Medical Research Institute, Nairobi 54840-00200, Kenya.; Monir SM; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Nguyen HT; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.; Huynh KM; Pasteur Institute in Nha Trang, 06-08-10 Tran Phu Street, Van Thanh Ward, Nha Trang 650000, Vietnam.; Ariyoshi N; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Le LT; Pasteur Institute in Nha Trang, 06-08-10 Tran Phu Street, Van Thanh Ward, Nha Trang 650000, Vietnam.; Le DT; Pasteur Institute in Nha Trang, 06-08-10 Tran Phu Street, Van Thanh Ward, Nha Trang 650000, Vietnam.; Nguyen TB; Pasteur Institute in Nha Trang, 06-08-10 Tran Phu Street, Van Thanh Ward, Nha Trang 650000, Vietnam.; Le HH; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.; Nguyen LD; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.; Pasteur Institute in Nha Trang, 06-08-10 Tran Phu Street, Van Thanh Ward, Nha Trang 650000, Vietnam.; Tsuruoka M; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Otomaru H; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Koehne E; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Toizumi M; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; School for Tropical Medicine and Global Health, Nagasaki University, Nagasaki 852-8523, Japan.; Dang DA; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.; Do HT; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Pasteur Institute in Nha Trang, 06-08-10 Tran Phu Street, Van Thanh Ward, Nha Trang 650000, Vietnam.; Yoshida LM; Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.; School for Tropical Medicine and Global Health, Nagasaki University, Nagasaki 852-8523, Japan. |
| Source: | Pathogens (Basel, Switzerland) [Pathogens] 2026 Feb 22; Vol. 15 (2). Date of Electronic Publication: 2026 Feb 22. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-0817 (Electronic) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, 2012- |
| MeSH Terms: | Methicillin-Resistant Staphylococcus aureus*/genetics ; Methicillin-Resistant Staphylococcus aureus*/drug effects ; Methicillin-Resistant Staphylococcus aureus*/isolation & purification ; Methicillin-Resistant Staphylococcus aureus*/classification ; Staphylococcal Infections*/epidemiology ; Staphylococcal Infections*/microbiology; Vietnam/epidemiology ; Anti-Bacterial Agents/pharmacology ; Carrier State/epidemiology ; Carrier State/microbiology ; Humans ; Child ; Adolescent ; Prevalence ; Female ; Male ; Cross-Sectional Studies ; Microbial Sensitivity Tests ; Schools ; Drug Resistance, Multiple, Bacterial |
| Abstract: | Staphylococcus aureus (S. aureus), especially Methicillin-resistant Staphylococcus aureus (MRSA), remains a major public health concern both in hospital and community settings. The MRSA carriage situation among schoolchildren in Vietnam is limited. A cross-sectional study was conducted in March 2023 to assess the prevalence, antimicrobial resistance patterns, and molecular characteristics of MRSA among schoolchildren in Nha Trang, Vietnam. Schoolchildren from grades 1 to 12 (ages 6-18 yrs) were enrolled. Background epidemiological data and nasal swabs were collected. Nasal samples were processed at the Pasteur Institute in Nha Trang, Vietnam, for S. aureus culture. Out of 1210 participants enrolled, S. aureus prevalence was 18.3% (222/1210), of which 41% (91/222) were MRSA. Primary school children showed the highest prevalence of MRSA colonization (48%), 32.8% in secondary, and 27.8% in high school. Among MRSA isolates, high levels of resistance were detected against trimethoprim-sulfamethoxazole (100%), erythromycin (68.2%) and clindamycin (45.1%). Multidrug resistance (MDR) occurred in 30% (27/90) of MRSA isolates. Staphylococcal cassette chromosome mec (SCCmec) subtype IVa was dominant (66.0%), followed by type IV (7.0%) and type V (6.0%). MLST data revealed genetic diversity whereby ST45 dominated, followed by ST546 and ST188. Continuous MRSA surveillance is essential to monitor emerging strains in the communities. |
| Grant Information: | JP21wm0125006 and JP223fa627004 Japan Agency for Medical Research and Development (AMED) |
| Contributed Indexing: | Keywords: Staphylococcus aureus; Vietnam; antibiotic resistance; methicillin-resistant Staphylococcus aureus; multi-locus sequence typing |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20260227 Date Completed: 20260306 Latest Revision: 20260306 |
| Update Code: | 20260306 |
| PubMed Central ID: | PMC12943241 |
| DOI: | 10.3390/pathogens15020238 |
| PMID: | 41754490 |
| Database: | MEDLINE |
Journal Article