Elevated ANG2/ACE2 and immune responses associated with Plasmodium falciparum and SARS-CoV-2 coinfection in Cameroon.
| Title: | Elevated ANG2/ACE2 and immune responses associated with Plasmodium falciparum and SARS-CoV-2 coinfection in Cameroon. |
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| Authors: | Tchoupe EB; Molecular Diagnostics Research Group (MDRG), Biotechnology Centre-University of Yaoundé I, Yaounde, Cameroon.; Department of Medical Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.; Kameni MN; Molecular Diagnostics Research Group (MDRG), Biotechnology Centre-University of Yaoundé I, Yaounde, Cameroon.; Department of Microbiology, Faculty of Sciences, University of Yaounde I, Yaounde, Cameroon.; Eric MB; Molecular Diagnostics Research Group (MDRG), Biotechnology Centre-University of Yaoundé I, Yaounde, Cameroon.; Department of Biochemistry, Faculty of Sciences, University of Yaounde I, Yaounde, Cameroon.; Taya JB; Molecular Diagnostics Research Group (MDRG), Biotechnology Centre-University of Yaoundé I, Yaounde, Cameroon.; Department of Microbiology, Faculty of Sciences, University of Yaounde I, Yaounde, Cameroon.; Kamdem SD; Molecular Diagnostics Research Group (MDRG), Biotechnology Centre-University of Yaoundé I, Yaounde, Cameroon.; Numfor Nkah L; Molecular Diagnostics Research Group (MDRG), Biotechnology Centre-University of Yaoundé I, Yaounde, Cameroon.; Ama Moor V; Department of Medical Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.; Tepa A; Department of Medical Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.; Neba FR; Molecular Diagnostics Research Group (MDRG), Biotechnology Centre-University of Yaoundé I, Yaounde, Cameroon.; Afum-Adjei Awuah A; Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.; Department of Infectious Diseases Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; Amuasi JH; Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.; Department of Infectious Diseases Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.; Netongo PM; Molecular Diagnostics Research Group (MDRG), Biotechnology Centre-University of Yaoundé I, Yaounde, Cameroon.; Department of Biochemistry, Faculty of Sciences, University of Yaounde I, Yaounde, Cameroon.; Biology Program, School of Science, Navajo Technical University, Crownpoint, New Mexico, United States of America. |
| Source: | PLOS global public health [PLOS Glob Public Health] 2026 Feb 27; Vol. 6 (2), pp. e0005010. Date of Electronic Publication: 2026 Feb 27 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 9918283779606676 Publication Model: eCollection Cited Medium: Internet ISSN: 2767-3375 (Electronic) Linking ISSN: 27673375 NLM ISO Abbreviation: PLOS Glob Public Health Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, California : Public Library of Science, [2021]- |
| Abstract: | Malaria and COVID-19 co-infections pose a major clinical challenge, as overlapping symptoms can lead to misdiagnosis and delays in treatment. Emerging evidence suggests that SARS-CoV-2 may influence malaria pathogenesis through dysregulation of the renin-angiotensin system. This study assessed clinical, biochemical, and immunological alterations associated with single and dual infections. A total of 96 participants aged 15-64 years were enrolled and classified into four groups: COVID-19 (n = 28), malaria (n = 28), co-infection (n = 16), and healthy controls (n = 24). Blood and nasopharyngeal samples were tested using rapid diagnostic tests, microscopy, and RT-PCR. Disease severity biomarkers were quantified using spectrophotometry and ELISA. Statistical analyses were performed in GraphPad Prism version 9.0, with significance set at p |
| Competing Interests: | The authors have declared that no competing interests exist. |
| Entry Date(s): | Date Created: 20260227 Date Completed: 20260227 Latest Revision: 20260301 |
| Update Code: | 20260301 |
| PubMed Central ID: | PMC12948122 |
| DOI: | 10.1371/journal.pgph.0005010 |
| PMID: | 41758897 |
| Database: | MEDLINE |
Journal Article