Comparison Between Visual Assessment and Apparent Diffusion Coefficient (ADC) Value Measurement on Diffusion Weighted Imaging (DWI) in Supratentorial Glioma Grading in Children.
| Title: | Comparison Between Visual Assessment and Apparent Diffusion Coefficient (ADC) Value Measurement on Diffusion Weighted Imaging (DWI) in Supratentorial Glioma Grading in Children. |
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| Authors: | Ngan VK; Department of Radiology, Hanoi Medical University, Hanoi, Vietnam.; Department of Radiology, Vinmec Healthcare System, Ha Noi, Viet Nam.; Hung ND; Department of Radiology, Hanoi Medical University, Hanoi, Vietnam.; Department of Radiology, Viet Duc Hospital, Hanoi, Vietnam.; Dung LT; Department of Radiology, Viet Duc Hospital, Hanoi, Vietnam.; Department of Radiology, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.; Ninh TP; Department of Radiology, Vietnam National Hospital of pediatrics, Hanoi, Vietnam. |
| Source: | Medical archives (Sarajevo, Bosnia and Herzegovina) [Med Arch] 2025; Vol. 79 (6), pp. 497-503. |
| Publication Type: | Journal Article; Comparative Study |
| Language: | English |
| Journal Info: | Publisher: Academy of Medical Sciences of Bosnia and Herzegovina Country of Publication: Bosnia and Herzegovina NLM ID: 101635337 Publication Model: Print Cited Medium: Internet ISSN: 1986-5961 (Electronic) Linking ISSN: 0350199X NLM ISO Abbreviation: Med Arch Subsets: MEDLINE |
| Imprint Name(s): | Publication: Sarajevo, Bosnia and Herzegovina : Academy of Medical Sciences of Bosnia and Herzegovina; Original Publication: Sarajevo, Bosnia and Herzegovina : Avicena, 2012- |
| MeSH Terms: | Diffusion Magnetic Resonance Imaging*/methods ; Glioma*/pathology ; Glioma*/diagnostic imaging ; Supratentorial Neoplasms*/diagnostic imaging ; Supratentorial Neoplasms*/pathology; Humans ; Male ; Female ; Child ; Prospective Studies ; Neoplasm Grading ; Child, Preschool ; Adolescent ; ROC Curve |
| Abstract: | Objective: Pediatric low-grade gliomas (pLGGs) and pediatric high-grade gliomas (pHGGs) have differences prognosis, treatment strategy and outcome. This study aimed to compare diagnostic accuracy between DWI visual scale assessment and ADC value measurement of solid component of tumors in grading pediatric supratentorial gliomas.; Methods: In a current prospective study, 43 pediatric patients with pathologically-confirmed gliomas who underwent baseline DWI were enrolled between October 2023 and March 2025. The patients were classified by histopathology according to tumoral grade: 23 had pLGGs and 20 had pHGGs. Two readers reviewed DWI visual scale independently and the disagreement was resolved by consensus. On the other hand, one reader measured ADC value of entire solid component of the tumor in axial slice with greatest dimension of solid component. Two data sets of visual scale and ADC value were analyzed and the comparison of diagnostic accuracy in pediatric supratentorial glioma grading was carried out by using area under the curve (AUC) of receiver operating characteristic curve (ROC).; Results: In terms of gender and age, there were no statistically significant differences between pLGGs and pHGGs. Regarding to DWI visual scale, there were no statistically significant differences between pLGGs and pHGGs of DWI visual scale 2, 3 and 4 with p value > 0.05. There were statistically significant differences between pLGGs and pHGGs of DWI visual scale 5 and of DWI visual assessment with p value = 0.002 and 0.002, respectively. If we used the cut off of DWI visual scale 5, the area under the curve (AUC), the sensitivity, specificity and accuracy were 0.738, 65.0%, 82.61% and 74.42%, respectively. With ADC value measurement, ADCmean, ADCmedian and ADCmin were significantly lower in pHGGs compared with pLGGs with p = 0.003, 0.005 and |
| Competing Interests: | The authors declare no conflict of interests. |
| Contributed Indexing: | Keywords: Diffusion-weighted imaging; High-grade glioma; Low-grade glioma; Pediatric glioma |
| Entry Date(s): | Date Created: 20260302 Date Completed: 20260306 Latest Revision: 20260306 |
| Update Code: | 20260306 |
| PubMed Central ID: | PMC12947908 |
| DOI: | 10.5455/medarh.2025.79.497-503 |
| PMID: | 41768208 |
| Database: | MEDLINE |
Journal Article; Comparative Study