Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals.
| Title: | Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals. |
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| Authors: | Wang H; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Nagarajan P; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Miller CL; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.; Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.; Noordam R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.; Health Campus the Hague/Public Health and Primary Care, Leiden University Medical Center, the Hague, Netherlands.; Westerman KE; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.; Brown MR; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.; Kraja AT; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.; O'Connell JR; Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Schwander K; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; Li C; Department of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center.; Sanghvi MM; Centre of Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, London, UK.; Barts Heart Centre, Barts Health NHS Trust, London, UK.; Song Y; Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA.; Department of Computer Engineering, University of Virginia, Charlottesville, VA, USA.; Bartz TM; Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA.; Braunack-Mayer V; Diabetes Center Berne, Bern, BE, Switzerland.; Chen L; Massachusetts General Hospital, Boston, MA,USA.; Du J; Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Dunca D; Centre of Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, London, UK.; Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; Gudmundsdottir V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, Department of Health Sciences, University of Iceland, Reykjavik, Iceland.; Guo X; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Harris SE; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK.; Highland HM; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Huang Z; Department of Epidemiology, Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine, New Orleans, LA, US.; Kang C; Graduate School of Data Science, Seoul National University, Seoul, South Korea.; Lakka TA; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Lefevre C; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.; Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.; Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Missikpode C; Division of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.; Morrison JL; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.; Palmer ND; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.; Richmond A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Shahisavandi M; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.; Tang J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Weiss S; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Yu C; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; Zhu W; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Ansari MAY; Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.; Anugu P; Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.; Aschard H; Department of Computational Biology, F-75015 Paris, France Institut Pasteur, Université Paris Cité, Paris, France.; Department of Epidemiology, Harvard TH School of Public Health, Boston, MA, USA.; Ashok K; Broad Institute, Cambridge, MA, USA.; Attia JR; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.; Bazzano LA; Department of Epidemiology, Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine, New Orleans, LA, US.; Cade BE; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Dimitrov LM; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.; Do A; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.; Faquih T; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; FinesilverSmith SL; Centre of Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, London, UK.; Fisher-Hoch SP; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.; Fretts AM; Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA.; Gharib SA; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.; Goodarzi MO; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Graff M; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Gu C; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.; Hanson P; Massachusetts General Hospital, Boston, MA,USA.; He J; Department of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Heikkinen S; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.; Hixson J; Department of Epidemiology, School of Public Health, UTHealth Houston, Houston, TX, USA.; Hsu S; Massachusetts General Hospital, Boston, MA,USA.; Kähönen M; Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Kho M; Graduate School of Data Science, Seoul National University, Seoul, South Korea.; Kim H; Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA.; Komulainen P; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD, USA.; Lemaitre RN; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; McNeil JJ; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; McCormick JB; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.; Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Raitakari OT; Centre for Population Health Research, Department of Clinical Physiology and Nuclear Medicine, InFLAMES Research Flagship, Turku University Hospital and University of Turku, Turku, Finland.; Ramírez J; Centre of Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, London, UK.; Aragon Institute of Engineering Research, University of Zaragoza, Zaragoza, Spain.; Riha RL; Department of Sleep Medicine, The University of Edinburgh, Edinburgh, UK.; Risch M; Central Laboratory, Cantonal Hospital Graubünden, Chur, Switzerland.; Dr. Risch Medical Laboratory, Vaduz, Liechtenstein.; Risch L; Faculty of Medical Sciences, Institute for Laboratory Medicine, Private University in the Principality of Liechtenstein, Triesen, Liechtenstein.; Center of Laboratory Medicine, Institute of Clinical Chemistry, University of Bern and Inselspital, Bern, Switzerland.; Russ TC; Alzheimer Scotland Dementia Research Centre, Department of Psychology, The University of Edinburgh, Edinburgh, UK.; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK.; Sarnowski C; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.; Schram MT; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.; Scott RJ; School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.; Sofer T; CardioVascular Institute (CVI), Beth Israel Deaconness Medical Center, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Sun Q; Department of Biostatistics, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Völker U; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Wang Y; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; van Dijk KW; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.; Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands.; Wood AC; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Young KL; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Zhang R; Department of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Below JE; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Conen D; Population Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Cox SR; Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK.; Fox ER; Division of Cardiovascular Disease, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.; Franceschini N; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Ghanbari M; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.; Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Centre for Neurodegenerative Diseases, Site Rostock/Greifswald, Greifswald, Germany.; Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, Department of Health Sciences, University of Iceland, Reykjavik, Iceland.; Hayward C; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Holliday EG; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.; Jaquish CE; Division of Cardiovascular Science, Epidemiology Branch, NHLBI, NIH, Bethesda, Maryland, USA.; Lacaze P; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.; Lee S; Graduate School of Data Science, Seoul National University, Seoul, South Korea.; Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Morrison AC; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.; North KE; Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.; Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.; Rotter JI; The Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.; Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Wagenknecht LE; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA.; Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.; Giri A; Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.; Kelly TN; Division of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.; Munroe PB; Centre of Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, London, UK.; Gauderman J; Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.; Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; de Vries PS; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.; Rao DC; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.; Manning AK; Massachusetts General Hospital, Boston, MA,USA.; Chen H; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.; de Las Fuentes L; Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.; Cardiovascular Division, Department of Medicine, Washington University School of Medicine in St. Louis, MO, USA.; Redline S; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Meigs JB; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA. |
| Corporate Authors: | Lifelines Cohort Study |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2026 Mar 03. Date of Electronic Publication: 2026 Mar 03. |
| Publication Type: | Journal Article; Preprint |
| Language: | English |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Abstract: | Both short and long sleep duration have been associated with poor glycemic control and an increased risk of developing type 2 diabetes mellitus. Although sleep duration may differentially modify the effects of genetic risk factors for type 2 diabetes, this has not been systematically investigated. In the present study, we conducted genome-wide gene by sleep duration meta-analyses, separately assessing interactions of short and long sleep, for fasting glucose, fasting insulin, and hemoglobin A1c in up to 489,309 individuals without diabetes from seven different population groups. In total, 16 loci were identified to interact with sleep duration - six with short sleep and ten with long sleep. Of these, four loci were identified through cross-population meta-analysis. Mapped genes exhibit pathway connections to pericyte apoptosis, NMDA receptor activity, the GLUT1 receptor, neurological health, and sleep architecture. Eleven loci (VRK2, PCDH7, TFAP2A, CAP2, PAPPA, ZCCHC2, MYH9, SGIP1, JAKMIP3, RRAS2, MAPT) have not been reported in previous glycemic trait genome-wide association studies. Interaction loci identify divergent biological mechanisms for short and long sleep duration influencing glycemic control, suggesting specific pathways of intervention for precision medicine approaches to diabetes prevention and management. |
| Entry Date(s): | Date Created: 20260323 Date Completed: 20260330 Latest Revision: 20260330 |
| Update Code: | 20260330 |
| PubMed Central ID: | PMC13001383 |
| DOI: | 10.64898/2026.03.02.26346498 |
| PMID: | 41867174 |
| Database: | MEDLINE |
Journal Article; Preprint