Outcomes of the three-month weekly isoniazid with rifapentine (3HP) versus the six-month isoniazid preventive therapy (6H) among people newly enrolled in HIV care in western Kenya.
| Title: | Outcomes of the three-month weekly isoniazid with rifapentine (3HP) versus the six-month isoniazid preventive therapy (6H) among people newly enrolled in HIV care in western Kenya. |
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| Authors: | Onyango DO; Mecha JO; Njagi LN; Aoro S; Malika T; Kinuthia J; John-Stewart G; LaCourse SM |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2026 Mar 05. Date of Electronic Publication: 2026 Mar 05. |
| Publication Type: | Journal Article; Preprint |
| Language: | English |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Abstract: | Background: In trials, three-month weekly rifapentine and isoniazid (3HP) showed higher adherence and completion than the six-month daily isoniazid (6H) regimen for TB preventive treatment (TPT). However, programmatic outcome data remain limited.; Methodology: We evaluated the TPT cascade among people with HIV (PWH) aged > 15 years newly enrolled in HIV care in western Kenya. Initiation and completion of 6H (Jan to Sept 2022) were compared to 3HP (Oct 2022-Sept 2023) using Chi-square tests. Correlates of non-initiation and non-completion were assessed using Poisson regression with generalized linear models. Mortality within 24 months was evaluated using Cox proportional hazards regression.; Results: Of 1,930 PWH (median age 33 years [IQR=27-41]), 65.8% were female, and 19.5% had AHD at enrolment. Overall, 1,922 (99.6%) were screened for active TB, of whom 1,790 (97.5%) were TPT-eligible; 1577 (88.1%) of these initiated TPT. TPT initiation was higher with 3HP than 6H (89.8% vs. 84.2%; p |
| Entry Date(s): | Date Created: 20260323 Date Completed: 20260323 Latest Revision: 20260323 |
| Update Code: | 20260323 |
| PubMed Central ID: | PMC13001390 |
| DOI: | 10.64898/2026.03.04.26347621 |
| PMID: | 41867187 |
| Database: | MEDLINE |
Journal Article; Preprint