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Short-term blood pressure variability after continuous versus interval aerobic training combined with resistance exercise in ischemic heart disease: a pilot study.

Title: Short-term blood pressure variability after continuous versus interval aerobic training combined with resistance exercise in ischemic heart disease: a pilot study.
Authors: Vitarelli M; Department of Human Science and Promotion of Quality of Life, San Raffaele Open University, Rome, Italy; Department of Neurosciences, Biomedicine and Movement, University of Verona, Verona.; Calandri C; Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome.; Caminiti G; Department of Human Science and Promotion of Quality of Life, San Raffaele Open University, Rome, Italy; Department of Rehabilitation Cardiology, IRCCS San Raffaele Pisana, Rome.; Volterrani M; Department of Human Science and Promotion of Quality of Life, San Raffaele Open University, Rome, Italy; Department of Rehabilitation Cardiology, IRCCS San Raffaele Pisana, Rome.; Iellamo F; Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome.; Perrone MA; Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome.; Giamundo DM; Division of Cardiology, Policlinico Casilino, Rome.; Marazzi G; Department of Rehabilitation Cardiology, IRCCS San Raffaele Pisana, Rome.; Ruscello B; Department of Human Science and Promotion of Quality of Life, San Raffaele Open University, Rome, Italy; Department of Industrial Engineering, Faculty of Engineering, 'Tor Vergata' University, Rome, Italy; LUISS SportLab, Rome.; Padua E; Department of Human Science and Promotion of Quality of Life, San Raffaele Open University, Rome.; Antelmi A; Department of Human Science and Promotion of Quality of Life, San Raffaele Open University, Rome.; Morsella V; Department of Rehabilitation Cardiology, IRCCS San Raffaele Pisana, Rome.
Source: European journal of translational myology [Eur J Transl Myol] 2026 Mar 25. Date of Electronic Publication: 2026 Mar 25.
Publication Model: Ahead of Print
Publication Type: Journal Article
Language: English
Journal Info: Publisher: PagePress Country of Publication: Italy NLM ID: 101576208 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2037-7452 (Print) Linking ISSN: 20377452 NLM ISO Abbreviation: Eur J Transl Myol
Imprint Name(s): Publication: : Pavia : PagePress; Original Publication: Padova : Unipress
Abstract: Arterial hypertension and increased Blood Pressure Variability (BPV) are major prognostic determinants in patients with Ischemic Heart Disease (IHD). This randomized pilot study compared the effects of Continuous Combined Training (CCT; moderate-intensity continuous aerobic exercise plus resistance training) and Interval Combined Training (ICT; high-intensity interval aerobic exercise plus resistance training) on BPV and Blood Pressure (BP) parameters. Thirty-six clinically stable patients with IHD and hypertension were randomized to CCT or ICT for 12 weeks. Between-group changes in the study outcome were analysed by ANCOVA. Short-term systolic BPV significantly decreased in the CCT group but remained unchanged in the ICT group: [adjusted between-group difference -2.1 mmHg (95% CI: -3.2 to -1.4; p = 0.036). Resting systolic BP decreased similarly in both groups, whereas no significant changes were observed in 24-hour BP values. Peak oxygen uptake improved in both groups with a greater increase in the ICT group [adjusted between-groups difference +1.7 mL·kg⁻¹·min⁻¹ (95% CI: 0.7 to 2.2; p = 0.044). These findings suggest that, in patients with IHD, continuous combined training may be more effective than interval combined training in reducing short-term BPV, whereas interval training may confer greater improvements in aerobic capacity. Further adequately powered studies are warranted to confirm these results.
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Contributed Indexing: Keywords: Combined interval training; blood pressure variability; hypertension; ischemic heart disease
Entry Date(s): Date Created: 20260326 Latest Revision: 20260326
Update Code: 20260326
DOI: 10.4081/ejtm.2026.14885
PMID: 41885791
Database: MEDLINE

Journal Article