Sinonasal Inverted Papillomas: Predictors of Recurrence and Malignant Transformation.
| Title: | Sinonasal Inverted Papillomas: Predictors of Recurrence and Malignant Transformation. |
|---|---|
| Authors: | Tanase I; Department of Otorhinolaryngology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Ciolofan MS; Department of Otorhinolaryngology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Sarafoleanu CC; Department of Otorhinolaryngology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Mogoantă CA; Department of Otorhinolaryngology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Badea FC; ENT Department, Medicover Hospital, 020331 Bucharest, Romania.; Busuioc CI; Department of Pathology, Sfanta Maria Hospital, 011172 Bucharest, Romania.; Tarabichi S; Doctoral School, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Milea A; Doctoral School, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Liliac IM; Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Iovanescu D; Department of Otorhinolaryngology, 'Victor Babes' University of Medicine and Pharmacy, 300113 Timisoara, Romania.; Iovanescu G; Department of Otorhinolaryngology, 'Victor Babes' University of Medicine and Pharmacy, 300113 Timisoara, Romania.; Musat GC; Department of Otorhinolaryngology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. |
| Source: | Life (Basel, Switzerland) [Life (Basel)] 2026 Mar 09; Vol. 16 (3). Date of Electronic Publication: 2026 Mar 09. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101580444 Publication Model: Electronic Cited Medium: Print ISSN: 2075-1729 (Print) Linking ISSN: 20751729 NLM ISO Abbreviation: Life (Basel) Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI AG, 2011- |
| Abstract: | Sinonasal inverted papillomas (IPs) are rare benign tumors with ~15% postoperative recurrence and a ~8% risk of malignant transformation, with human papillomavirus (HPV) reported as a risk factor in IP malignant transformation. To evaluate clinical, molecular and immunohistochemical factors associated with recurrence and malignant transformation in IPs. We retrospectively analyzed 73 patients with histologically confirmed IPs that were treated at three tertiary ENT centers, including radiologic data, HPV DNA detection and p16 immunohistochemistry. Univariate analysis was used to identify factors associated with recurrence and malignant transformation, and restricted exploratory multivariable logistic regression models were used to assess recurrence while minimizing overfitting. Fourteen recurrences (19%) were associated with longer symptom duration (p = 0.003), smoking (p = 0.03), advanced Krouse stage (III-IV) (p < 0.001), frontal sinus origin (p = 0.02), HPV+ DNA (50% vs. 22%, p = 0.048), and p16 loss/reduced expression (p = 0.006). Nine recurrences transformed into carcinoma (12%) and were associated with smoking (p = 0.01). HPV+ was not associated with malignancy (p = 1.00). Recurrence was associated with the advanced stage of the IP, tobacco use, longer symptom duration, frontal sinus origin, HPV+, and p16 loss/reduced expression. |
| Contributed Indexing: | Keywords: HPV; inverted papilloma; malignant transformation; p16; recurrence |
| Entry Date(s): | Date Created: 20260328 Date Completed: 20260328 Latest Revision: 20260330 |
| Update Code: | 20260422 |
| PubMed Central ID: | PMC13027472 |
| DOI: | 10.3390/life16030442 |
| PMID: | 41900961 |
| Database: | MEDLINE |
Journal Article