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Pulsed-field ablation versus thermal ablation for atrial fibrillation: an updated systematic review and meta -analysis of randomized controlled trials and observational studies with time-to-event analysis.

Title: Pulsed-field ablation versus thermal ablation for atrial fibrillation: an updated systematic review and meta -analysis of randomized controlled trials and observational studies with time-to-event analysis.
Authors: Humayun Z; Department of Internal Medicine, University of Missouri, Kansas City, MO, USA.; Majeed MW; VMMC and Safdarjangh Hospital, New Delhi, India.; Joshi DK; Narendra Modi Medical College and Sheth L.G.Hospital, Ahmedabad, India.; Ayesha A; Shifa College of Medicine, Islamabad, Pakistan.; Ruelas MG; Instituto de Investigación Nutricional (IIN), Lima, Peru.; Consoli L; Federal University of Bahia, Salvador, Brazil.; Baqal O; Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ, USA.; Arham M; Sheikh Zayed Medical College, Rahim Yar Khan, Pakistan. md.muhammadarham@gmail.com.; Wani SA; Department of Internal Medicine, Wayne State University, Detroit, MI, USA.; Azeem B; Department of Cardiology, Shaheed Muhtarma Benazir Bhutto liyari Medical College, Karachi, Pakistan.; Naveed MA; Department of Cardiology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.; Ali A; Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.; Silva BR; Pontifical Catholic University, Goias, Brazil.; Kofahi A; Division of Cardiology, Wayne State University, Detroit, MI, USA.; Munir MB; Division of Cardiology, University of California Davis, Sacramento, CA, USA.; DeSimone CV; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.; Lee JZ; Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA.; Asif T; Saint Luke's Mid America Heart Institute, Kansas City, MO, USA.
Source: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing [J Interv Card Electrophysiol] 2026 Mar 30. Date of Electronic Publication: 2026 Mar 30.
Publication Model: Ahead of Print
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 9708966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1572-8595 (Electronic) Linking ISSN: 1383875X NLM ISO Abbreviation: J Interv Card Electrophysiol Subsets: MEDLINE
Imprint Name(s): Publication: Amsterdam : Springer; Original Publication: Norwell, MA : Kluwer Academic Publishers, c1997-
Competing Interests: Competing interests: The authors declare no competing interests. Disclosures: All authors reported no relationships that could be construed as conflict of interest. All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
References: Linz D, Gawalko M, Betz K, et al. Atrial fibrillation: epidemiology, screening and digital health. The Lancet Regional Health - Europe. 2024;37:100786. https://doi.org/10.1016/j.lanepe.2023.100786 . (PMID: 10.1016/j.lanepe.2023.10078610866942); Baqal O, Shafqat A, Kulthamrongsri N, Sanghavi N, Iyengar SK, Vemulapalli HS, et al. Ablation strategies for persistent atrial fibrillation: beyond the pulmonary veins. J Clin Med. 2024;13(17):5031. (PMID: 10.3390/jcm131750313927424411396655); Natale A, Mohanty S, Goldstein L, Gomez T, Hunter TD. Real-world safety of catheter ablation for atrial fibrillation with contact force or cryoballoon ablation. J Interv Card Electrophysiol. 2021;60(3):445–52. https://doi.org/10.1007/s10840-020-00734-w . (PMID: 10.1007/s10840-020-00734-w32390061); Batista Napotnik T, Polajžer T, Miklavčič D. Cell death due to electroporation - a review. Bioelectrochemistry. 2021;141:107871. https://doi.org/10.1016/j.bioelechem.2021.107871 . (PMID: 10.1016/j.bioelechem.2021.10787134147013); de Campos MCAV, Moraes VRY, Daher RF, et al. Pulsed-field ablation versus thermal ablation for atrial fibrillation: a meta-analysis. Heart Rhythm O2. 2024;5(6):385–95. https://doi.org/10.1016/j.hroo.2024.04.012 . (PMID: 10.1016/j.hroo.2024.04.0123898436311228281); Kaddoura R, Abushanab D, Asaad N. Pulsed-field ablation versus radiofrequency or cryoballoon thermal ablation in atrial fibrillation: a systematic review and meta-analysis. Postgrad Med J. 2025. https://doi.org/10.1093/postmj/qgaf049 . (PMID: 10.1093/postmj/qgaf049); Amin AM, Nazir A, Abuelazm MT, Ibrahim AA, Elbenawi H, Aboutaleb A, Ellabban M, Arnaout M, Turkmani M, Abdelazeem B, Volgman AS. Efficacy and safety of pulsed-field versus conventional thermal ablation for atrial fibrillation: a systematic review and meta-analysis. J Arrhythm. 2024;40(5):1059–74. https://doi.org/10.1002/joa3.13118 . (PMID: 10.1002/joa3.131183941625411474578); Iqbal M, Kamarullah W, Pranata R, Putra ICS, Karwiky G, Achmad C, et al. Meta-analysis of pulsed field ablation versus thermal ablation for pulmonary vein isolation in AF: a broad overview focusing on efficacy, safety and outcomes. Arrhythm Electrophysiol Rev. 2024;13:e13. https://doi.org/10.15420/aer.2024.05 . (PMID: 10.15420/aer.2024.05); Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editors. Cochrane Handbook for Systematic Reviews of Interventions version 6.5 (updated August 2024). Cochrane, 2024. Available from www.training.cochrane.org/handbook.; Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71 . (PMID: 10.1136/bmj.n71337820578005924); Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. https://doi.org/10.1136/bmj.l4898 . (PMID: 10.1136/bmj.l489831462531); Sterne JA, Hernán MA, Reeves BC, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355:i4919. https://doi.org/10.1136/bmj.i4919 . (PMID: 10.1136/bmj.i4919277333545062054); Iyengar SK, Iyengar S, Srivathsan K. The promise of pulsed field ablation and the challenges ahead. Front Cardiovasc Med. 2023;10:1235317. https://doi.org/10.3389/fcvm.2023.1235317 . (PMID: 10.3389/fcvm.2023.1235317); Turagam MK, Neuzil P, Schmidt B, et al. Safety and effectiveness of pulsed field ablation to treat atrial fibrillation: one-year outcomes from the MANIFEST-PF registry. Circulation. 2023;148(1):35–46. https://doi.org/10.1161/CIRCULATIONAHA.123.064959 . (PMID: 10.1161/CIRCULATIONAHA.123.06495937199171); Ekanem E, Neuzil P, Reichlin T, et al. Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study. Nat Med. 2024;30(7):2020–9. https://doi.org/10.1038/s41591-024-03114-3 . (PMID: 10.1038/s41591-024-03114-311271404); Reddy VY, Gerstenfeld EP, Natale A, et al. Pulsed Field or Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation. N Engl J Med. 2023;389(18):1660–71. https://doi.org/10.1056/NEJMoa2307291 . (PMID: 10.1056/NEJMoa230729137634148); Reichlin T, Kueffer T, Badertscher P, et al. Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation. N Engl J Med. 2025;392(15):1497–507. https://doi.org/10.1056/NEJMoa2502280 . (PMID: 10.1056/NEJMoa250228040162734); Koruth J, Kuroki K, Iwasawa J, Enomoto Y, Viswanathan R, Brose R, et al. Preclinical evaluation of pulsed field ablation: electrophysiological and histological assessment of thoracic vein isolation. Circ Arrhythm Electrophysiol. 2019;12:e007781. https://doi.org/10.1161/CIRCEP.119.007781 . (PMID: 10.1161/CIRCEP.119.00778131826647); Reddy VY, et al. Pulsed Field or Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation. N Engl J Med. 2023;389(18):1660–71. (PMID: 10.1056/NEJMoa230729137634148); Reichlin T, et al. Pulsed Field or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation. N Engl J Med. 2025;392(15):1497–507. (PMID: 10.1056/NEJMoa250228040162734); Reddy Vivek Y, et al. Pulsed Field vs Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation. JACC. 2024;84(1):61–74. (PMID: 10.1016/j.jacc.2024.05.001); Matteucci A, et al. Impact of ablation energy sources on perceived quality of life and symptom in atrial fibrillation patients: a comparative study. J Clin Med. 2025. https://doi.org/10.3390/jcm14082741 . (PMID: 10.3390/jcm1408274141375802); Du Y, et al. Comparing the effects of pulsed and radiofrequency catheter ablation on quality of life, anxiety, and depression of patients with paroxysmal supraventricular tachycardia: a single-center, randomized, single-blind, standard-controlled trial. Trials. 2024;25(1):146. (PMID: 10.1186/s13063-024-07971-83840219210893749); Hashim U, et al. Patient comfort and response pattern following pulsed-field ablation compared to radiofrequency ablation for atrial fibrillation. J Cardiovasc Electrophysiol. 2025. https://doi.org/10.1111/jce.70077 . (PMID: 10.1111/jce.7007740958137); Kaddoura R, Abushanab D, Asaad N. Pulsed-field ablation versus radiofrequency or cryoballoon thermal ablation in atrial fibrillation: a systematic review and meta-analysis. Postgrad Med J. 2025;101(1198):690–703. (PMID: 10.1093/postmj/qgaf04940197795); Shtembari J, et al. Efficacy and safety of pulsed field ablation in atrial fibrillation: a systematic review. J Clin Med. 2023. https://doi.org/10.3390/jcm12020719 . (PMID: 10.3390/jcm120207193710913410144838); Ezzeddine FM, Asirvatham SJ, Nguyen DT. Pulsed field ablation: a comprehensive update. J Clin Med. 2024;13(17):5191. https://doi.org/10.3390/jcm13175191 . (PMID: 10.3390/jcm131751913927440411396515); Musikantow DR, Neuzil P, Petru J, Koruth JS, Kralovec S, Miller MA, Funasako M, Chovanec M, Turagam MK, Whang W, et al. Pulsed Field Ablation to Treat Atrial Fibrillation: Autonomic Nervous System Effects. JACC Clin Electrophysiol. 2023;9:481–93. https://doi.org/10.1016/j.jacep.2022.10.028 . (PMID: 10.1016/j.jacep.2022.10.02836752473); Musikantow DR, Reddy VY, Skalsky I, Shaburishvili T, van Zyl M, O’Brien B, et al. Targeted ablation of epicardial ganglionated plexi during cardiac surgery with pulsed field electroporation (NEURAL AF). J Interv Card Electrophysiol. 2023. https://doi.org/10.1007/s10840-023-01615-8 . (PMID: 10.1007/s10840-023-01615-8); Gerstenfeld EP, Mansour M, Whang W, Venkateswaran R, Harding JD, Ellis CR, Ellenbogen KA, Osorio J, DeLurgio DB, Daccarett M, et al. Autonomic Effects of Pulsed Field vs Thermal Ablation for Treating Atrial Fibrillation: Subanalysis of ADVENT. JACC Clin Electrophysiol. 2024;10:1634–44. https://doi.org/10.1016/j.jacep.2024.05.005 . (PMID: 10.1016/j.jacep.2024.05.00538869507)
Contributed Indexing: Keywords: Atrial Fibrillation; Cryoballoon; Pulse Field Ablation; Radiofrequency ablation; Rhythm Control; Thermal Ablation
Entry Date(s): Date Created: 20260330 Latest Revision: 20260330
Update Code: 20260330
DOI: 10.1007/s10840-026-02282-1
PMID: 41910891
Database: MEDLINE

Journal Article; Review