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Short-term natural history of non-perfusion areas in treatment-naive diabetic retinopathy patients using swept-source OCT angiography.

Title: Short-term natural history of non-perfusion areas in treatment-naive diabetic retinopathy patients using swept-source OCT angiography.
Authors: Ding X; Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street , Boston, MA, 02114, USA.; Romano F; Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street , Boston, MA, 02114, USA.; Garcia MD; Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Garg I; Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Gan J; Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Overbey KM; Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Vingopoulos F; Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Bennett CF; Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Shan M; Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Stettler I; Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Finn MJ; Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.; Vavvas DG; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street , Boston, MA, 02114, USA.; Husain D; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street , Boston, MA, 02114, USA.; Wu DM; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street , Boston, MA, 02114, USA.; Patel NA; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street , Boston, MA, 02114, USA.; Kim LA; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street , Boston, MA, 02114, USA.; Miller JB; Harvard Retinal Imaging Lab, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA. john_miller@meei.harvard.edu.; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street , Boston, MA, 02114, USA. john_miller@meei.harvard.edu.
Source: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2026 Mar 31. Date of Electronic Publication: 2026 Mar 31.
Publication Model: Ahead of Print
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 8205248 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-702X (Electronic) Linking ISSN: 0721832X NLM ISO Abbreviation: Graefes Arch Clin Exp Ophthalmol Subsets: MEDLINE
Imprint Name(s): Original Publication: Berlin ; New York : Springer-Verlag, c1982-
Competing Interests: Declarations. Research Ethics Approval: This study involves human participants and was approved by the Institutional 29 Review Board of Massachusetts General Brigham (protocol: 2019P001863). Conflict of interest: no conflicting relationship relevant to this research. Financial Disclosures: JBM is a consultant for Alcon, Allergan, Carl Zeiss, Sunovion, Topcon, and Genentech. DGV has been an advisor to Drusolv; is an inventor on patents of Neuroprotection held by Mass Eye and Ear. DH is a consultant for Allergan, Genetech, Omeicos Therapeutics, and has received financial support from National Eye Institute, Lions VisionGift, Commonwealth Grant, Lions International and the Macula Society. LAK is a consultant for Ingenia Therapeutics, CureVac AG, Pykus Therapeutics, and has received grant support from the National Eye Institute and the Department of Defense. NAP is a consultant for Regeneron, Dutch Ophthalmic, Genentech, EyePoint Pharmaceuticals, Alcon Vision. DMW has a patent through Massachusetts Eye and Ear. XD, FR, IG, JG, KMO, MDG, FV, IS, MS, MJF, CFB have no relevant financial disclosures.
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Contributed Indexing: Keywords: diabetic retinopathy; non-perfusion areas; progression; swept-source OCTA
Entry Date(s): Date Created: 20260331 Latest Revision: 20260331
Update Code: 20260331
DOI: 10.1007/s00417-026-07186-4
PMID: 41915053
Database: MEDLINE

Journal Article