Fat Oxidation, But Not Subcutaneous Adipose Tissue Lipolysis, Differs Between Males and Females During a Treadmill-Based Heat Tolerance Test.
| Title: | Fat Oxidation, But Not Subcutaneous Adipose Tissue Lipolysis, Differs Between Males and Females During a Treadmill-Based Heat Tolerance Test. |
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| Authors: | Morrissey-Basler MC; Department of Kinesiology, Korey Stringer Institute, University of Connecticut, Storrs, Connecticut, USA.; Department of Health Sciences, Providence College, Providence, Rhode Island, USA.; Szymanski MR; Department of Kinesiology, Korey Stringer Institute, University of Connecticut, Storrs, Connecticut, USA.; Department of Clinical and Applied Movement of Sciences, University of Northern Florida, Jacksonville, Florida, USA.; Filep EM; Department of Kinesiology, Korey Stringer Institute, University of Connecticut, Storrs, Connecticut, USA.; School of Sport Science, Endicott College, Beverly, Massachusetts, USA.; Langan SP; Department of Kinesiology, Korey Stringer Institute, University of Connecticut, Storrs, Connecticut, USA.; VO Health, Inc., New Haven, Connecticut, USA.; Ormsbee MJ; Department of Nutrition, Food and Exercise Sciences, Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, Florida, USA.; Discipline of Biokinetics, Exercise and Leisure Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.; Lee EC; Department of Kinesiology, Korey Stringer Institute, University of Connecticut, Storrs, Connecticut, USA.; Department of Kinesiology, University of Connecticut, Storrs, Connecticut, USA.; Casa DJ; Department of Kinesiology, Korey Stringer Institute, University of Connecticut, Storrs, Connecticut, USA.; Department of Kinesiology, University of Connecticut, Storrs, Connecticut, USA. |
| Source: | European journal of sport science [Eur J Sport Sci] 2026 May; Vol. 26 (5), pp. e70162. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Wiley-VCH GmbH on behalf of European College of Sport Science Country of Publication: Germany NLM ID: 101146739 Publication Model: Print Cited Medium: Internet ISSN: 1536-7290 (Electronic) Linking ISSN: 15367290 NLM ISO Abbreviation: Eur J Sport Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : Germany : Wiley-VCH GmbH on behalf of European College of Sport Science; Original Publication: [Champaign, Ill.] : Human Kinetics, [2001- |
| MeSH Terms: | Lipolysis*/physiology ; Subcutaneous Fat*/metabolism ; Exercise*/physiology ; Lipid Metabolism*; Glycerol/metabolism ; Insulin/blood ; Epinephrine/blood ; Fatty Acids, Nonesterified/blood ; Hydrocortisone/blood ; Norepinephrine/blood ; Humans ; Male ; Female ; Young Adult ; Adult ; Energy Metabolism ; Exercise Test ; Oxidation-Reduction ; Sex Factors |
| Abstract: | This study aimed to determine whether fat metabolism differs between males and females when exposed to extreme exercise-heat stress. Physically active males (n = 11, 23 ± 4 years, 81.7 ± 11.8 kg, body fat 16.4 ± 6.6%) and females (n = 13, 25 ± 4 years, 60.4 ± 7.1 kg, 24.4 ± 6.7%) completed a 2-h exercise-heat tolerance test (40 INLINEMATH C, 40% relative humidity). Differences (pre-, post-, change, and mean difference (MD)) within and between groups were analyzed. The subcutaneous abdominal adipose tissue (SCAAT) interstitial glycerol concentration and adipose tissue blood flow (ethanol Output:Input (O:I)) pre-exercise, every 30 min (min) of exercise, and during recovery was measured with microdialysis. Non-esterified fatty acids, insulin, insulin-like growth factor, epinephrine and norepinephrine, and cortisol were measured in blood. Resting energy expenditure (REE) was measured pre- and post-exercise and exercising metabolic heat production (MHP) was collected during 30 and 90 min of the HTT. Despite no sex differences in systemic blood biomarkers, fat oxidation (g × min-1) was higher in males (M) (vs. Females (F)) at 30 min of HTT (3.92 ± 0.25 (M), 3.58 ± 0.38 (F), p = 0.021). SCAAT interstitial glycerol was similar across all time points between sexes (baseline glycerol ranges (mmol × L-1): 104.6-1260.0 (F), 165.0-775.6 (M)); however, females had a greater O:I ratio at 90 min of exercise (vs. M) (0.69 ± 0.33 (F); 0.44 ± 0.20 (M); p = 0.033). Pre- and post-exercise REE were 23% (MD: 447.5 kcal × day-1, p |
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| Grant Information: | BA200299 U.S. Department of Defense |
| Contributed Indexing: | Keywords: fat metabolism; heat stress; substrate utilization; thermal physiology |
| Substance Nomenclature: | PDC6A3C0OX (Glycerol); 0 (Insulin); YKH834O4BH (Epinephrine); 0 (Fatty Acids, Nonesterified); WI4X0X7BPJ (Hydrocortisone); X4W3ENH1CV (Norepinephrine) |
| Entry Date(s): | Date Created: 20260404 Date Completed: 20260404 Latest Revision: 20260430 |
| Update Code: | 20260501 |
| PubMed Central ID: | PMC13052184 |
| DOI: | 10.1002/ejsc.70162 |
| PMID: | 41934339 |
| Database: | MEDLINE |
Journal Article