Evaluation of non-sputum-based diagnostics for pediatric tuberculosis: the Pediatric TB Diagnostic (PDTBDx) cohort protocol.
| Title: | Evaluation of non-sputum-based diagnostics for pediatric tuberculosis: the Pediatric TB Diagnostic (PDTBDx) cohort protocol. |
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| Authors: | Mullen B; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.; Githua J; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; Department of Medical Microbiology and Immunology, University of Nairobi, Nairobi, Kenya.; Escudero JN; Department of Global Health, University of Washington, Seattle, WA, USA.; Mecha J; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; Department of Mathematics, University of Nairobi, Nairobi, Kenya.; Kijaro L; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; Ndunge M; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; Muriithi M; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; Kibet I; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; John-Stewart G; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Maleche-Obimbo E; Department of Global Health, University of Washington, Seattle, WA, USA.; Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.; Nduba V; Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.; LaCourse SM; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA. |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2026 Apr 03. Date of Electronic Publication: 2026 Apr 03. |
| Publication Type: | Journal Article; Preprint |
| Language: | English |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Abstract: | Tuberculosis (TB) is a significant cause of morbidity and mortality in children and adolescents, causing 172,000 deaths in 2024 in children and adolescents worldwide. Diagnostic challenges are pronounced in pediatrics, in which collecting respiratory specimens is challenging and TB is often paucibacillary, leading to delayed diagnosis and increased mortality. We describe the protocol and methodology of the Pediatric TB Diagnostic (PDTBDx) cohort, a study with the primary aim of evaluating non-sputum-based TB diagnostics for diagnosis and treatment response in children. This is a prospective observational cohort study of >400 children recruited from inpatient and outpatient clinical sites in Nairobi, Kenya. Children |
| Competing Interests: | CONFLICTS OF INTEREST The authors report no conflicts of interest. |
| Entry Date(s): | Date Created: 20260410 Date Completed: 20260427 Latest Revision: 20260427 |
| Update Code: | 20260427 |
| PubMed Central ID: | PMC13060392 |
| DOI: | 10.64898/2026.04.01.26350011 |
| PMID: | 41959800 |
| Database: | MEDLINE |
Journal Article; Preprint