Retrospective analysis of platelet rich plasma injections for ankle osteoarthritis in athletic population.
| Title: | Retrospective analysis of platelet rich plasma injections for ankle osteoarthritis in athletic population. |
|---|---|
| Authors: | Natali S; Department of Orthopaedics, IRCCS Ospedale Sacro Cuore Don Calabria, Viale Luigi Rizzardi, 4, Negrar di Valpolicella, Verona, 37024, Italy. simone.natali@sacrocuore.it.; Venanzio I; Department of Orthopaedics, IRCCS Ospedale Sacro Cuore Don Calabria, Viale Luigi Rizzardi, 4, Negrar di Valpolicella, Verona, 37024, Italy.; Screpis D; Department of Orthopaedics, IRCCS Ospedale Sacro Cuore Don Calabria, Viale Luigi Rizzardi, 4, Negrar di Valpolicella, Verona, 37024, Italy.; Piovan G; Department of Orthopaedics, IRCCS Ospedale Sacro Cuore Don Calabria, Viale Luigi Rizzardi, 4, Negrar di Valpolicella, Verona, 37024, Italy.; Mazzucco L; Blood Component and Regenerative Medicine Laboratory, Alessandria Hospital, Alessandria, Italy.; Zorzi C; Department of Orthopaedics, IRCCS Ospedale Sacro Cuore Don Calabria, Viale Luigi Rizzardi, 4, Negrar di Valpolicella, Verona, 37024, Italy. |
| Source: | BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2026 Apr 13. Date of Electronic Publication: 2026 Apr 13. |
| Publication Model: | Ahead of Print |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-2474 (Electronic) Linking ISSN: 14712474 NLM ISO Abbreviation: BMC Musculoskelet Disord Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BioMed Central, [2000- |
| Competing Interests: | Declarations. Ethics approval and consent to participate: This retrospective, single-centre, uncontrolled, pilot study was conducted with the highest respect for individual participants. All patients provided their informed consent to the use of their medical records and personal data at the time of admission. The procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the revision of the Declaration of Helsinki, 2024. The study protocol was reviewed and approved by the Ethics Committee of the Clinical Research Unit, IRCCS Sacro Cuore Don Calabria Hospital, Verona (protocol no. 61386, approved on 19 September 2018). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
| References: | Allen KD, Thoma LM, Golightly YM. Epidemiology of osteoarthritis. Osteoarthr Cartil. 2022;30(2):184–95. https://doi.org/10.1016/j.joca.2021.04.020.; Long H, Liu Q, Yin H, Wang K, Diao N, Zhang Y, et al. Prevalence trends of site‐specific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019. Arthritis Rheumatol. 2022;74(7):1172–83. https://doi.org/10.1002/art.42089.; Huch K, Kuettner KE, Dieppe P. Osteoarthritis in ankle and knee joints. Semin Arthritis Rheum. 1997;26(4):667–74. https://doi.org/10.1016/S0049-0172(97)80002-9.; Herrera-Pérez M, González-Martín D, Vallejo-Márquez M, Godoy-Santos AL, Valderrabano V, Tejero S Ankle osteoarthritis aetiology. J Clin Med. 2021;10(19):4489. . https://doi.org/10.3390/jcm10194489.; Godoy-Santos AL, Fonseca LF, De Cesar Netto C, Giordano V, Valderrabano V, Rammelt S. Osteoartrite do tornozelo. Rev Bras Ortop. 2021;56(06):689–96. https://doi.org/10.1055/s-0040-1709733.; Anderson DD, Ledoux WR, Lenz AL, Wilken J, Easley ME, De Cesar Netto C. Ankle osteoarthritis: toward new understanding and opportunities for prevention and intervention. J Orthop Res. 2024;42(12):2613–22. https://doi.org/10.1002/jor.25973.; Kon E, Filardo G, Di Martino A, Marcacci M. Platelet-rich plasma (PRP) to treat sports injuries: evidence to support its use. Knee Surg Sports Traumatol Arthrosc. 2011;19(4):516–27. https://doi.org/10.1007/s00167-010-1306-y.; Whittaker JL, Roos EM. A pragmatic approach to prevent post-traumatic osteoarthritis after sport or exercise-related joint injury. Best Pract Res Clin Rheumatol. 2019;33(1):158–71. https://doi.org/10.1016/j.berh.2019.02.008.; Bennell K, Hunter DJ, Vicenzino B. Long-term effects of sport: preventing and managing OA in the athlete. Nat Rev Rheumato. 2012;8(12):747–52. https://doi.org/10.1038/nrrheum.2012.119.; Arumugam S, Prakash A, Janani G, Vignesh M, Anjanavannan MM, Perumal S, et al. Platelet-Rich Plasma (PRP) injection in sports injuries. Indian J Orthop. 2021;55(2):484–91. https://doi.org/10.1007/s43465-020-00349-3.; Martel-Pelletier J, Barr AJ, Cicuttini FM, Conaghan PG, Cooper C, Goldring MB, et al. Osteoarthr Nat Rev Dis Primer. 2016;2(1):16072. https://doi.org/10.1038/nrdp.2016.72.; Herrera-Pérez M, Valderrabano V, Godoy-Santos AL, De César Netto C, González-Martín D, Tejero S. Ankle osteoarthritis: comprehensive review and treatment algorithm proposal. EFORT Open Rev. 2022;7(7):448–59. https://doi.org/10.1530/EOR-21-0117.; Vannini F, Di Matteo B, Filardo G, Kon E, Marcacci M, Giannini S. Platelet-rich plasma for foot and ankle pathologies: a systematic review. Foot Ankle Surg. 2014;20(1):2–9. https://doi.org/10.1016/j.fas.2013.08.001.; Pavlovic V, Ciric M, Jovanovic V, Stojanovic P. Platelet Rich Plasma: a short overview of certain bioactive components. Open Med. 2016;11(1):242–7. https://doi.org/10.1515/med-2016-0048.; Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med. 2009;37(11):2259–72. https://doi.org/10.1177/0363546509349921.; Frey E, Brown CD, Tripp B. Effectiveness of platelet-rich plasma in reducing pain and increasing function after acute lateral ankle sprain: a critically appraised topic. J Sport Rehabil. 2024;33(7):558–61. https://doi.org/10.1123/jsr.2023-0425.; Medina-Porqueres I, Martin-Garcia P, Sanz-De-Diego S, Reyes-Eldblom M, Moya-Torrecilla F, Mondragon-Cortes R, et al. Platelet-rich plasma injections in chronic lateral ankle instability: a case series. Biomedicines. 2024;12(5):963. https://doi.org/10.3390/biomedicines12050963.; Laohajaroensombat S, Prusmetikul S, Rattanasiri S, Thakkinstian A, Woratanarat P. Platelet-rich plasma injection for the treatment of ankle osteoarthritis: a systematic review and meta-analysis. J Orthop Surg. 2023;18(1):373. https://doi.org/10.1186/s13018-023-03828-z.; Soomekh DJ. Current Concepts for the Use of Platelet-rich plasma in the foot and ankle. Clin Podiatr Med Surg. 2011;28(1):155–70. https://doi.org/10.1016/j.cpm.2010.09.001.; Kitaoka HB, Alexander IJ, Adelaar RS, Nunley JA, Myerson MS, Sanders M. Clinical rating systems for the ankle-hindfoot, midfoot, hallux, and lesser toes. Foot Ankle Int. 1994;15(7):349–53. https://doi.org/10.1177/107110079401500701.; Free Online AOFAS. Ankle hindfoot scale calculator - OrthoToolKit. Disponibile su: https://orthotoolkit.com/aofas-ankle-hindfoot/.; Koo M, Yang SW. Visual analogue scale. Encyclopedia. 2025;5(4):190. https://doi.org/10.3390/encyclopedia5040190.; Fukawa T, Yamaguchi S, Akatsu Y, Yamamoto Y, Akagi R, Sasho T. Safety and efficacy of intra-articular injection of platelet-rich plasma in patients with ankle osteoarthritis. Foot Ankle Int. 2017;38(6):596–604. https://doi.org/10.1177/1071100717700377.; Kraeutler MJ, Kaenkumchorn T, Pascual-Garrido C, Wimmer MA, Chubinskaya S. Peculiarities in ankle cartilage. Cartil. 2017;8(1):12–8. https://doi.org/10.1177/1947603516642572.; Xiong Y, Gong C, Peng X, Liu X, Su X, Tao X, et al. Efficacy and safety of platelet-rich plasma injections for the treatment of osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Front Med. 2023;10:1204144. https://doi.org/10.3389/fmed.2023.1204144.; Zhu Y, Yuan M, Meng HY, Wang AY, Guo QY, Wang Y, et al. Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a review. Osteoarthr Cartil. 2013;21(11):1627–37. https://doi.org/10.1016/j.joca.2013.07.017.; Gabay C, Lamacchia C, Palmer G. IL-1 pathways in inflammation and human diseases. Nat Rev Rheumatol. 2010;6(4):232–41. https://doi.org/10.1038/nrrheum.2010.4.; Pujol JP, Loyau G. Minireview Interleukin-1 and osteoarthritis. Life Sci. 1987;41(10):1187–98. https://doi.org/10.1016/0024-3205(87)90196-2.; Ding Q, Wang X, Liu Y, Li Y, Zhang D, Wang H, et al. The efficacy of platelet-rich plasma in ankle disease: a systematic review and meta-analysis. J Orthop Surg. 2024;19(1):895. https://doi.org/10.1186/s13018-024-05420-5.; Paget LDA, Reurink G, De Vos RJ, Weir A, Moen MH, Bierma-Zeinstra SMA, et al Effect of platelet-rich plasma injections vs placebo on ankle symptoms and function in patients with ankle osteoarthritis: a randomized clinical trial. JAMA. 2021;326(16):1595. . https://doi.org/10.1001/jama.2021.16602.; Samra DJ, Sman AD, Rae K, Linklater J, Refshauge KM, Hiller CE. Effectiveness of a single platelet-rich plasma injection to promote recovery in rugby players with ankle syndesmosis injury. BMJ Open Sport Exerc Med. 2015;1(1):e000033. https://doi.org/10.1136/bmjsem-2015-000033.; Jones R, Gilbert SJ, Christofides SR, Mason DJ. Osteocytes contribute to sex-specific differences in osteoarthritic pain. Front Endocrinol. 2024;15:1480274. https://doi.org/10.3389/fendo.2024.1480274.; Sun SF, Hsu CW, Lin GC, Lin HS, Chou YJ, Wu SY, et al. Efficacy and safety of a single intra-articular injection of platelet-rich plasma on pain and physical function in patients with ankle osteoarthritis—a prospective study. J Foot Ankle Surg. 2021;60(4):676–82. https://doi.org/10.1053/j.jfas.2020.12.003. |
| Contributed Indexing: | Keywords: Ankle osteoarthritis; Intra-articular injection; Pain management; Platelet-rich plasma (PRP); Return to sport |
| Entry Date(s): | Date Created: 20260414 Latest Revision: 20260414 |
| Update Code: | 20260414 |
| DOI: | 10.1186/s12891-026-09790-1 |
| PMID: | 41975388 |
| Database: | MEDLINE |
Journal Article