Systemic Inflammation and Structural Retinal Damage on OCT in Acute Non-Arteritic Central Retinal Artery Occlusion-A Retrospective Study.
| Title: | Systemic Inflammation and Structural Retinal Damage on OCT in Acute Non-Arteritic Central Retinal Artery Occlusion-A Retrospective Study. |
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| Authors: | Nica AM; Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania.; Ophthalmology, 2nd Surgery Department, Saint Spiridon Emergency Hospital, 700111 Iasi, Romania.; Ciuntu RE; Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania.; Ophthalmology, 2nd Surgery Department, Saint Spiridon Emergency Hospital, 700111 Iasi, Romania.; Nica SA; Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania.; Otorhinolaryngology, 2nd Surgery Department, Saint Spiridon Emergency Hospital, 700111 Iasi, Romania.; Dascalu CG; Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania.; Ganea CV; Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania.; Ophthalmology, 2nd Surgery Department, Saint Spiridon Emergency Hospital, 700111 Iasi, Romania.; Corlade-Andrei M; Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania.; Emergency Medicine, 2nd Surgery Department, Saint Spiridon Emergency Hospital, 700111 Iasi, Romania.; Morariu PC; Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania.; Department of Internal Medicine, Saint Spiridon Emergency Hospital, 700111 Iasi, Romania.; Godun MM; Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania.; Department of Internal Medicine, Saint Spiridon Emergency Hospital, 700111 Iasi, Romania.; Oancea AF; Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania.; Department of Internal Medicine, Saint Spiridon Emergency Hospital, 700111 Iasi, Romania.; Marcu DT; Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania.; Department of Internal Medicine, Saint Spiridon Emergency Hospital, 700111 Iasi, Romania.; Bogdănici CM; Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania.; Ophthalmology, 2nd Surgery Department, Saint Spiridon Emergency Hospital, 700111 Iasi, Romania.; Floria M; Grigore T. Popa University of Medicine and Pharmacy Iasi, 16 University Street, 700115 Iasi, Romania.; Department of Internal Medicine, Saint Spiridon Emergency Hospital, 700111 Iasi, Romania. |
| Source: | International journal of molecular sciences [Int J Mol Sci] 2026 Mar 24; Vol. 27 (7). Date of Electronic Publication: 2026 Mar 24. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, [2000- |
| MeSH Terms: | Tomography, Optical Coherence*/methods ; Retinal Artery Occlusion*/diagnostic imaging ; Retinal Artery Occlusion*/pathology ; Retinal Artery Occlusion*/blood ; Inflammation*/pathology ; Retina*/pathology ; Retina*/diagnostic imaging; Neutrophils/pathology ; Lymphocytes/pathology ; Humans ; Female ; Male ; Retrospective Studies ; Aged ; Middle Aged ; Aged, 80 and over ; Biomarkers |
| Abstract: | Central retinal artery occlusion (CRAO) is an acute ophthalmic emergency causing irreversible vision loss due to retinal ischemia. Inflammation is increasingly recognized as a contributor to vascular occlusions, but the relationship between systemic inflammatory biomarkers and structural retinal damage in CRAO remains unclear. This retrospective study included 37 patients with non-arteritic CRAO presenting within 168 h of symptom onset. Optical coherence tomography (OCT) classified ischemic severity as mild, moderate, or severe based on inner retinal morphology. Systemic inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and systemic inflammation response index (SIRI), were calculated from admission blood tests, and associations were analyzed using ordinal logistic regression. Increasing severity correlated with higher NLR and SII values (p < 0.05). Univariable analysis showed significant associations for NLR, SII, neutrophil count, white blood cell count, and central macular thickness (CMT). Multivariable regression identified NLR (OR = 8.398, p = 0.007) and CMT (OR = 1.052, p = 0.001) as independent predictors of greater ischemic damage. Other indices were not significant. These findings indicate that NLR is the primary systemic inflammatory predictor of OCT-defined severity in acute CRAO, with CMT providing complementary structural information. |
| Contributed Indexing: | Keywords: central retinal artery occlusion; inflammatory indices; neutrophil-to-lymphocyte ratio; optical coherence tomography; retinal ischemia; systemic inflammation |
| Substance Nomenclature: | 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20260414 Date Completed: 20260414 Latest Revision: 20260416 |
| Update Code: | 20260416 |
| PubMed Central ID: | PMC13073957 |
| DOI: | 10.3390/ijms27072961 |
| PMID: | 41977151 |
| Database: | MEDLINE |
Journal Article