Levodopa-Induced dyskinesia in Latin America: Prevalence and associated clinical factors in the LARGE-PD cohort.
| Title: | Levodopa-Induced dyskinesia in Latin America: Prevalence and associated clinical factors in the LARGE-PD cohort. |
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| Authors: | Chaparro-Solano HM; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.; Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.; Teixeira-Dos-Santos D; Center for Neurological Restoration, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.; Department of Neurology, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350, Porto Alegre, RS, 90035-003, Brazil.; Waldo E; Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.; Leal TP; Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.; Inca-Martinez M; Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.; Alcauter S; Instituto de Neurobiología, Universidad Nacional Autónoma de México, Blvd Juriquilla 3001, Santiago de Querétaro, 76230, Mexico.; Medina-Rivera A; Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Blvd Juriquilla 3001, Santiago de Querétaro, 76230, Mexico.; Ruiz-Contreras AE; Laboratorio de Neurogenómica Cognitiva, Unidad de Psicobiología y Neurociencias, Facultad de Psicología, Universidad Nacional Autónoma de México, Av. Universidad 3004, Ciudad de México, 04510, Mexico.; Cornejo-Olivas M; Neurogenetics Working Group, Universidad Cientifica del Sur, Panamerica Sur Km 19, Lima, 15067, Peru.; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, 1271 Ancash St, Lima, 15003, Peru.; Mejia-Rojas K; EDMECON Medical Center, Continuing Medical Education, C. Los Antares 308, Santiago de Surco, Lima, 15039, Peru.; Department of Neurology, Daniel Alcides Carrion National Hospital, Av. Guardia Chalaca 2176, Bellavista, Callao, 07016, Peru.; Armas C; Department of Neurodegenerative Diseases and Movement Disorders Unit, Instituto Nacional de Ciencias Neurológicas, Jr. Ancash 1271, Cercado de Lima, Lima, 15003, Peru.; Chana-Cuevas P; Centro de Trastornos del Movimiento, Universidad de Santiago de Chile, Av Jose Joaquin Prieto Vial 7271, Lo espejo, Santiago, 9120500, Chile.; Rojas N; Investigación, Corporación Centro de Trastornos del Movimiento, Av Jose Joaquin Prieto Vial 7271, Lo espejo, Santiago, 9120500, Chile.; Orozco JL; Neurology Department, Fundación Valle del Lili - Universidad Icesi, Carrera 98 No. 18-49, Oficina 460, Cali, Valle del Cauca, Colombia.; Ospina BM; Human Sciences Department, Universidad Icesi, Calle 18 No. 122-135, Cali, Valle del Cauca, Colombia.; Adults Neuropsychology, Fundación Valle del Lili, Carrera 98 No. 18-49, Cali, Colombia.; Aguillon D; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, St 64 No. 51-31, Medellín, Antioquia, 050010, Colombia.; Buritica O; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, St 64 No. 51-31, Medellín, Antioquia, 050010, Colombia.; Masmela SM; Facultad de Medicina, Universidad de Antioquia, Calle 62 No. 52-59, Medellín, Antioquia, 050010, Colombia.; Tumas V; Department of Neurosciences and Behavior Sciences, Ribeirão Preto Medical School, Universidade de São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil.; Schuh AF; Department of Neurology, Hospital de Clinicas de Porto Alegre, Rua Ramiro Barcelos 2350, Porto Alegre, RS, 90035-003, Brazil.; Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600, Predio 21116, Porto Alegre, RS, 90035003, Brazil.; Rieder CR; Department of Clinical Medicine, Universidade Federal de Ciências da Saúde de Porto Alegre, R. Sarmento Leite, 245 - Centro Histórico, Porto Alegre, RS, 90050-170, Brazil.; Santos-Lobato BL; Serviço de Neurologia, Hospital Ophir Loyola, Av. Gov. Magalhães Barata, 992, Belém, PA, 66063-240, Brazil.; Laboratório de Neuropatologia Experimental, Universidade Federal do Pará, Rua dos Mundurucus, 4487, Belém, PA, 66073-000, Brazil.; Duarte JS; Laboratório de Neuropatologia Experimental, Universidade Federal do Pará, Augusto Corrêa Street, No. 01, Guamá, Belém, PA, 66075-100, Brazil.; Peña Martínez SL; Research Department, Universidad Andrés Bello, 1ª Calle Pte. 2128, San Salvador, El Salvador.; Rodríguez-Violante M; Laboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Insurgentes Sur 3877, La Fama, Tlalpan, Ciudad de México, 14269, México.; Hernández-Medrano AJ; Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Blvd Juriquilla 3001, Santiago de Querétaro, 76230, Mexico.; Gatto EM; Neurology, Clinic Sanatorio de la Trinidad Mitre, Bartolome Mitre 2553, Buenos Aires, Argentina.; Da Prat De Magalhaes GA; Movement Disorder Department, Instituto de Neurociencias de Buenos Aires, Guardia Vieja 4435, Capital Federal, 1192, Argentina.; Arboleda G; Departamento de Patología, Instituto de Genética, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Ciudad Universitaria, Bogotá, Colombia.; Kauffman MA; Neurogenetics Unit, Hospital JM Ramos Mejia-Conicet, General Urquiza 609, Buenos Aires, Argentina.; Rodriguez-Quiroga SA; Neurogenetics Unit, Hospital JM Ramos Mejia-Conicet, General Urquiza 609, Buenos Aires, Argentina.; University Centre of Neurology, Faculty of Medicine, Buenos Aires University, Buenos Aires, Argentina.; Vinuela A; Ponce School of Medicine, Fundación Parkinson Puerto Rico, Luis F. Sala Street, Ponce, 00716-2347, Puerto Rico.; Neurosciences Institute Manati Medical Center, Calle Hernandez Carrion, Manatí, 00674, Puerto Rico.; Espinal Martinez AO; Fundación Parkinson Puerto Rico, Torre II, Centro Internacional de Mercadeo, Oficina 302, Guaynabo, 00965, Puerto Rico.; School of Medicine, Universidad Autónoma de Guadalajara, Av. Universidad 700, Lomas del Valle, Zapopan, Jalisco, 45129, Mexico.; Braga-Neto P; Clinical Medicine, Universidade Federal do Ceará, Rua Professor Costa Mendes 1608, 4th floor, Rodolfo Teófilo, Fortaleza, CE, 60430-140, Brazil.; Camargos S; School of Medicine, Universidade Federal de Minas Gerais, Av. Professor Alfredo Balena, 190, Belo Horizonte, Minas Gerais, Brazil.; Hospital das Clinicas da Universidade Federal de Minas Gerais, Av. Professor Alfredo Balena, 115, Belo Horizonte, Minas Gerais, Brazil.; Fernandez-Toledo E; Departamento de Especialidades, Facultad de Medicina, Universidad de Concepción, Janequeo esquina, Av. Chacabuco S/N, Concepción, Bío Bío, Chile.; Servicio de Neurología, Hospital Guillermo Grant Benavente, San Martín, 1436, Concepción, Bío Bío, Chile.; Avila CL; Instituto de Investigación en Biologia Molecular y Celular Aplicada, Universidad Nacional de Tucuman, Consejo Nacional de Investigaciones Científicas y Técnicas, 1080 Dorrego, San Miguel de Tucumán, 4000, Argentina.; Cardoso FE; Movement Disorders Unit, Neurology Service, The Internal Medicine Department, Universidade Federal de Minas Gerais, Av Pasteur 89/1107, 30150-290, Belo Horizonte, Minas Gerais, Brazil.; Olguin P; Instituto de Ciencias Biomédicas, Departamento de Neurociencias, Universidad de Chile, Avenida Independencia 1027, Santiago de Chile, Chile.; Borges V; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, Escola Paulista de Medicina UNIFESP-EPM, Rua Botucatu, 740, São Paulo, SP, 04023-900, Brazil.; Müller MV; Neurology Unit, Hospital Interzonal General de Agudos General San Martín, 1st & 70th Streets, Buenos Aires, La Plata 1900, Argentina.; Alianza Argentina de Pacientes, 2527 Dorrego Ave, C1425, Buenos Aires, Argentina.; Merello M; Movement Disorders, Fleni, Montañeses 2325 CABA 1428, Buenos Aires, Argentina.; Rosso A; Neurology Department - HUCFF, Universidade Federal do Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, Rio de Janeiro, RJ, Brazil.; Martinez-Ramirez D; Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Avenida Morones Prieto 3000, Sertoma, Monterrey, NL, 64710, Mexico.; Adamec DS; Neurocirugia Funcional, Hospital Profesor Alejandro Posadas, Av Illia s/n, El Palomar, Buenos Aires, Argentina.; Tela MS; Servicio de Neurologia, Hospital General de Agudos Juan A. Fernandez, Cerviño 3356, Ciudad Autónoma de Buenos Aires, Argentina.; Letro GH; Hospital PUC-Campinas, Avenida John Boyd Dunlop s/n, Campinas, SP, 13034-685, Brazil.; Departamento de Neurologia Clínica, Pontifícia Universidade de Campinas, Avenida John Boyd Dunlop s/n, Campinas, SP, 13034-685, Brazil.; Nicaretta DH; Departamento de Medicina Especializada, Universidade Federal do Estado do Rio de Janeiro, Escola de Medicina e Cirurgia, Hospital Universitário Gaffrée GUINLE-EBSERH, Rua Mariz e Barros, 775 Rio de Janeiro, RJ, 20270-00, Brazil.; Mata IF; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.; Genomic Sciences and Systems Biology, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. |
| Corporate Authors: | Latin American Research consortium on the Genetics of Parkinson's Disease (LARGE-PD) |
| Source: | Journal of Parkinson's disease [J Parkinsons Dis] 2026 Jun; Vol. 16 (4), pp. 723-735. Date of Electronic Publication: 2026 Apr 17. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: IOS Press Country of Publication: United States NLM ID: 101567362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : IOS Press |
| MeSH Terms: | Levodopa*/adverse effects ; Parkinson Disease*/drug therapy ; Parkinson Disease*/epidemiology ; Antiparkinson Agents*/adverse effects ; Dyskinesia, Drug-Induced*/epidemiology ; Dyskinesia, Drug-Induced*/etiology; Latin America/epidemiology ; Humans ; Prevalence ; Female ; Male ; Cross-Sectional Studies ; Aged ; Middle Aged |
| Abstract: | BackgroundAlthough levodopa is the gold standard treatment for Parkinson's disease (PD), its chronic use is associated with levodopa-induced dyskinesia (LID), a motor complication that impacts prognosis, quality of life, and treatment costs. Most known LID-associated factors have been identified in European-descendant populations.ObjectivesTo describe the epidemiology of LID in Latin American and Caribbean (LATAM) countries and assess the relevance of known and novel LID-associated factors in this population.MethodsWe conducted a cross-sectional study using data from the Latin American Research consortium on the Genetics of Parkinson's Disease (LARGE-PD). We included PD patients with information on LID status and levodopa use from eight LATAM countries. LID prevalence was calculated overall and by country. Countries were compared on demographic and clinical variables. Logistic regression was used to identify associations with LID.ResultsA total of 3695 PD patients (58.8% male) were included. Overall LID prevalence was 25.4% [95% CI: 24.06-26.87], ranging from 9.3% in Colombia to 45.1% in Puerto Rico. Prevalence increased progressively with longer disease duration. Country comparisons showed that not all known LID-associated factors explained prevalence differences. In logistic regression, fast disease progression was significantly associated with LID (OR: 1.55, 95%CI: 1.16-2.07), while sex was not (OR: 1.02, 95%CI: 0.87-1.18).ConclusionsThis is the largest study on LID epidemiology in LATAM. While some known risk factors remain relevant, others, like sex, do not, underscoring the need for population-specific studies. Future work should integrate environmental, clinical, and genetic data to better understand LID mechanisms. |
| Competing Interests: | Declaration of conflicting interestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: I.F.M. receives honoraria from the Parkinson's Foundation for his role as a member of the PDGENEration Steering Committee. |
| Comments: | Update of: medRxiv. 2025 Aug 27:2025.08.25.25334104. doi: 10.1101/2025.08.25.25334104.. (PMID: 40909824) |
| Contributed Indexing: | Keywords: Latin America; Parkinson's disease; dyskinesia; epidemiology; levodopa |
| Substance Nomenclature: | 46627O600J (Levodopa); 0 (Antiparkinson Agents) |
| Entry Date(s): | Date Created: 20260417 Date Completed: 20260613 Latest Revision: 20260613 |
| Update Code: | 20260615 |
| DOI: | 10.1177/1877718X261431204 |
| PMID: | 41995451 |
| Database: | MEDLINE |
Journal Article