Management of incidental gallbladder cancer in a nationwide CAPBIL study.
| Title: | Management of incidental gallbladder cancer in a nationwide CAPBIL study. |
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| Authors: | McClements J; Belfast Health and Social Care Trust, Belfast, UK.; Lee WT; Nottingham University Hospitals NHS Trust, Nottingham, UK.; Koh A; Nottingham University Hospitals NHS Trust, Nottingham, UK.; Sellappan H; Nottingham University Hospitals NHS Trust, Nottingham, UK.; Blackburn L; Nottingham University Hospitals NHS Trust, Nottingham, UK.; Brooks A; Nottingham University Hospitals NHS Trust, Nottingham, UK.; Nixon G; Belfast Health and Social Care Trust, Belfast, UK.; Merali N; Royal Surrey Hospital, London, UK.; Frampton A; Royal Surrey Hospital, London, UK.; Safavi D; Royal Free London NHS Foundation Trust, London, UK.; Davidson B; Royal Free London NHS Foundation Trust, London, UK.; Feretis M; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Dasari BVM; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Chin SL; University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Karavias D; University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Rowcroft A; NHS Lothian, Edinburgh, UK.; Lucocq J; NHS Lothian, Edinburgh, UK.; Harrison EM; NHS Lothian, Edinburgh, UK.; Morrison-Jones V; Basingstoke and North Hampshire Hospital, Basingstoke, UK.; Welsh F; Basingstoke and North Hampshire Hospital, Basingstoke, UK.; Pathanki A; University Hospital Coventry & Warwickshire NHS Trust, Coventry, UK.; Marangoni G; University Hospital Coventry & Warwickshire NHS Trust, Coventry, UK.; Bruno P; University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.; Skipworth J; University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.; Colucci N; Cambridge University Hospitals, Cambridge, UK.; Kosmoliaptsis V; Cambridge University Hospitals, Cambridge, UK.; O'Leary L; Aintree University Hospital, UK.; Malik H; Aintree University Hospital, UK.; Hamadalnile A; King's College Hospital NHS Foundation Trust, London, UK.; Menon K; King's College Hospital NHS Foundation Trust, London, UK.; Patel W; East Lancashire Hospitals NHS Trust, Blackburn, UK.; Bekheit M; East Lancashire Hospitals NHS Trust, Blackburn, UK.; Tanno L; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Silva M; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Brown C; Cardiff and Vale University Health Board, Cardiff, UK.; Kumar N; Cardiff and Vale University Health Board, Cardiff, UK.; Triance J; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.; Shah N; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.; Alsaoudi T; University Hospitals of Leicester, Leicester, UK.; Bhardwaj N; University Hospitals of Leicester, Leicester, UK.; Nassar H; The Royal London Hospital, London, UK.; Mownah O; The Royal London Hospital, London, UK.; Yeung KTD; The Royal Marsden NHS Foundation Trust, London, UK.; Bhogal R; The Royal Marsden NHS Foundation Trust, London, UK.; Blanco-Colino R; Leeds Teaching Hospitals NHS Trust, Leeds, UK.; Farid S; Leeds Teaching Hospitals NHS Trust, Leeds, UK.; Aljaberi R; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Pandanaboyana S; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Abdelmohsin O; University Hospitals Plymouth NHS Trust, Plymouth, UK.; Aroori S; University Hospitals Plymouth NHS Trust, Plymouth, UK.; Evans D; University Hospitals of North Midlands NHS Trust, Stoke on Trent, UK.; Athwal T; University Hospitals of North Midlands NHS Trust, Stoke on Trent, UK.; Lodge JPA; Leeds Teaching Hospitals NHS Trust, Leeds, UK.; Gomez D; Nottingham University Hospitals NHS Trust, Nottingham, UK. |
| Source: | The British journal of surgery [Br J Surg] 2026 Apr 21. Date of Electronic Publication: 2026 Apr 21. |
| Publication Model: | Ahead of Print |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press on behalf of BJS Foundation Ltd Country of Publication: England NLM ID: 0372553 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2168 (Electronic) Linking ISSN: 00071323 NLM ISO Abbreviation: Br J Surg Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2021- : [Oxford] : Oxford University Press on behalf of BJS Foundation Ltd.; Original Publication: [Bristol, England : Baltimore : John Wright & Sons ; Williams & Wilkins Co. |
| Abstract: | Introduction: To provide contemporary, real-world data on the management approaches and survival outcomes of patients with incidental gallbladder cancer (GBC) following cholecystectomy in the United Kingdom. The secondary aim was to identify prognostic factors associated with survival.; Methods: Patients diagnosed with incidental GBC following cholecystectomy between January 2014 and December 2022 across 24 centres were included. Data collected comprised demographics, treatment details, histopathological findings and survival outcomes.; Results: During the study period, 285 patients had incidental GBC. Median follow-up was 31 months, with 5-year disease-free (DFS) and overall (OS) survival of 41.5% and 45.1%, respectively. Of the 193 (67.7%) patients who underwent liver resection, most (97.9%) underwent segment 4B/5 resection. Patients with incidental GBC who underwent liver resection had significantly improved DFS (51 vs 15 months, p |
| Contributed Indexing: | Keywords: Chemotherapy; Gallbladder cancer; Liver resection; Local Abstract: [plain-language-summary] Gallbladder cancer (GBC) is sometimes discovered unexpectedly after gallbladder removal for presumed benign disease. This study examined how patients with this incidental GBC are treated across the United Kingdom and what factors influence survival. Data from 285 patients diagnosed with incidental GBC between 2014 and 2022 at 24 specialist centres were analysed. Two-thirds of patients underwent additional liver surgery after their initial gallbladder operation. Patients who had further liver surgery lived significantly longer than those who did not. Survival was also better in patients who completed chemotherapy after surgery. However, patients with more advanced tumours or cancer that had spread to nearby lymph nodes had poorer outcomes. These findings highlight the importance of further liver surgery and appropriate additional treatment in patients with incidental GBC. |
| Entry Date(s): | Date Created: 20260421 Latest Revision: 20260421 |
| Update Code: | 20260422 |
| DOI: | 10.1093/bjs/znag050 |
| PMID: | 42013358 |
| Database: | MEDLINE |
Journal Article