Overcoming itraconazole limitations via proline cocrystals: improved solubility, dissolution, and antifungal efficacy.
| Title: | Overcoming itraconazole limitations via proline cocrystals: improved solubility, dissolution, and antifungal efficacy. |
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| Authors: | Chavan DD; Department of Pharmacology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University).; Thorat VM; Department of Pharmacology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University).; Shete AS; Department of Pharmaceutics, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to Be University).; Bhosale RR; Department of Pharmaceutics, Krishna Charitable Trust's Krishna College of Pharmacy.; Awale ND; Research Group of Department of Pharmaceutics and Quality Assurance, Shree Santkrupa College of Pharmacy.; Patil PL; Research Group of Department of Pharmaceutics and Quality Assurance, Shree Santkrupa College of Pharmacy. |
| Source: | Fukushima journal of medical science [Fukushima J Med Sci] 2026 Apr 24. Date of Electronic Publication: 2026 Apr 24. |
| Publication Model: | Ahead of Print |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Fukushima Society of Medical Science Country of Publication: Japan NLM ID: 0374626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2185-4610 (Electronic) Linking ISSN: 00162590 NLM ISO Abbreviation: Fukushima J Med Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: Fukushima : Fukushima Society of Medical Science; Original Publication: Fukushima, Japan. Fukushima Kenritsu Ika Daigaku. |
| Abstract: | Crystal engineering plays a crucial role in the efficient design of pharmaceutical cocrystals, hinging on a deep understanding of intermolecular interactions that influence crystal packing. By leveraging these interactions, researchers can create innovative solid forms with customized physical and chemical properties. This versatile approach is especially valuable for tackling the solubility and bioavailability issues commonly associated with poorly soluble drugs. In this study, we focused on synthesizing cocrystals of itraconazole (ITZ) and proline via the kneading technique, an eco-friendly crystal engineering technique. Our work included comprehensive solid-state characterization, stability assessments, and in vitro efficacy evaluations. We specifically examined how these cocrystals performed in terms of dissolution, solubility, and antifungal activity. Our solid-state characterization results highlighted the formation of significant intermolecular interactions within the cocrystals, particularly hydrogen bonds between ITZ and the functional groups of proline. Notably, the ITZ-proline cocrystals demonstrated superior solubility and faster dissolution rates compared to pure ITZ, alongside increased crystallinity in the newly formed solid state. Additionally, the cocrystals exhibited enhanced antifungal activity and stability. Consequently, our findings have indicated that forming ITZ cocrystals with proline significantly enhances the solubility as well as stability of ITZ, thereby offering a promising antifungal strategy to combat fungal infections. |
| Contributed Indexing: | Keywords: Itraconazole; antifungal activity; cocrystals; solid-state characterization; stability; virtual screening |
| Entry Date(s): | Date Created: 20260426 Latest Revision: 20260426 |
| Update Code: | 20260427 |
| DOI: | 10.5387/fms.25-00012 |
| PMID: | 42036318 |
| Database: | MEDLINE |
Journal Article