Esthetic Unit-Based Surgical Management of Large Facial Plexiform Neurofibromas.
| Title: | Esthetic Unit-Based Surgical Management of Large Facial Plexiform Neurofibromas. |
|---|---|
| Authors: | Hoang TA; Department of Plastic Surgery, Hanoi Medical University.; Department of Microsurgery, Plastic, Aesthetic, and Maxillofacial Surgery, Hanoi Medical University Hospital.; Le DL; 108 Military Central Hospital, Hanoi, Vietnam.; Nguyen TD; Department of Plastic Surgery, Hanoi Medical University.; Nguyen ND; Department of Microsurgery, Plastic, Aesthetic, and Maxillofacial Surgery, Hanoi Medical University Hospital.; Phan VT; Department of Microsurgery, Plastic, Aesthetic, and Maxillofacial Surgery, Hanoi Medical University Hospital.; Tran ST; Department of Plastic Surgery, Hanoi Medical University. |
| Source: | The Journal of craniofacial surgery [J Craniofac Surg] 2026 May 05. Date of Electronic Publication: 2026 May 05. |
| Publication Model: | Ahead of Print |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9010410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-3732 (Electronic) Linking ISSN: 10492275 NLM ISO Abbreviation: J Craniofac Surg Subsets: MEDLINE |
| Imprint Name(s): | Publication: : Hagerstown, MD : Lippincott Williams & Wilkins; Original Publication: Burlington, Ont. : B.C. Decker, c1990- |
| Abstract: | Large facial plexiform neurofibromas in patients with neurofibromatosis type 1 (NF1) often cause extensive soft-tissue hypertrophy, facial asymmetry, and functional impairment, resulting in significant aesthetic and psychosocial morbidity. Complete excision is often unfeasible because of infiltrative growth, indistinct margins, and high tumor vascularity. Accordingly, staged resection combined with tailored reconstruction represents a pragmatic surgical strategy. The authors retrospectively evaluated outcomes of an aesthetic unit-based, staged surgical approach in patients with large facial plexiform neurofibromas treated at Hanoi Medical University Hospital and 108 Military Central Hospital between 2018 and 2024. Nineteen patients (12 females and 7 males; mean age, 28 years) were included. Tumors most commonly involve the cheek, temporal, and periorbital regions. Near-total excision (>90%) was achieved in 4 patients, subtotal excision (50%-90%) in 12 patients, and planned staged partial excision ( |
| Competing Interests: | The authors report no conflicts of interest. |
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| Contributed Indexing: | Keywords: Esthetic unit-based reconstruction; facial neurofibroma; neurofibromatosis type 1 |
| Entry Date(s): | Date Created: 20260505 Latest Revision: 20260505 |
| Update Code: | 20260505 |
| DOI: | 10.1097/SCS.0000000000012822 |
| PMID: | 42084415 |
| Database: | MEDLINE |
Journal Article