Chest radiographic findings suggestive of possible sarcoidosis in patients with nephrolithiasis.
| Title: | Chest radiographic findings suggestive of possible sarcoidosis in patients with nephrolithiasis. |
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| Authors: | Azizzade Dobakhshari M; Urology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.; Alavi Foumani A; Inflammatory Lung Disease Research Center, Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. fomanii99@gmail.com.; Jafari A; Urology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. dr.alireza.jafariii@gmail.com.; Infectious Disease Research Center, Avicenna Institute of Clinical Sciences, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran. dr.alireza.jafariii@gmail.com.; Falahatkar S; Urology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.; Maroufizadeh S; Department of Biostatistics, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.; Tangestani Nejad A; Inflammatory Lung Disease Research Center, Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.; Asghar A; Urology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.; Mousavi F; Inflammatory Lung Disease Research Center, Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.; Javaheri NZ; School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. |
| Source: | Scientific reports [Sci Rep] 2026 May 13; Vol. 16 (1). Date of Electronic Publication: 2026 May 13. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| MeSH Terms: | Nephrolithiasis*/complications ; Nephrolithiasis*/diagnostic imaging ; Sarcoidosis*/diagnostic imaging ; Sarcoidosis*/complications ; Radiography, Thoracic*; Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Cross-Sectional Studies ; Adult |
| Abstract: | Renal involvement in sarcoidosis may manifest as hypercalcemia, hypercalciuria, nephrolithiasis, nephrocalcinosis, and other abnormalities, but is often underrecognized. This study investigated chest radiographic findings suggestive of possible sarcoidosis in patients with nephrolithiasis and compared available laboratory parameters between patients with and without such findings. This retrospective analytical cross-sectional study included patients undergoing PCNL or TUL for urinary stones at Razi Hospital (Guilan, Iran) from 2016 to 2021. Routine preoperative chest X-rays were reviewed; 1297 encounters had both a retrievable diagnostic-quality CXR and available core laboratory data. Two pulmonologists independently interpreted CXRs for findings suggestive of possible sarcoidosis and assigned Scadding stage (0-IV), each blinded to the other's assessment; discrepancies were adjudicated by a third pulmonologist. Preoperative laboratory variables (BUN, creatinine, uric acid, alkaline phosphatase, calcium, phosphorus, AST, ALT, and CBC) were extracted and compared between patients with radiographic findings suggestive of possible sarcoidosis (RFS group) and those without such findings (non-RFS group) using Mann-Whitney U tests and chi-square/Cochran-Armitage trend tests. Logistic regression was used to examine the association between elevated creatinine and RFS. Radiographic findings suggestive of possible sarcoidosis were identified in 2.5% of patients, most commonly in middle-aged men and predominantly as Scadding stage I patterns. Creatinine levels were higher in the RFS group than in the non-RFS group. Elevated creatinine was associated with RFS in unadjusted analysis but not after adjustment for age and sex. Radiographic findings suggestive of possible sarcoidosis were identified in a small subset of nephrolithiasis patients. Although higher creatinine levels were observed in this group, this finding should be interpreted cautiously. Chest radiography may help identify patients who warrant further evaluation, but prospective studies incorporating confirmatory diagnostic methods are needed to clarify the clinical significance of these findings.; (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This research received approval from the Ethics Committee of Guilan University of Medical Sciences (Ethics Code: IR.GUMS.REC.1403.162). The data were retrieved on 22 July 2024 exclusively for research purposes. To safeguard participant privacy, all medical records and imaging files were fully anonymized prior to any analysis. Data were obtained using a unique Hospital Admission Code, and all personal identifiers and any potentially identifying details were removed before the dataset was provided to the research team. Due to the retrospective design of the study and the exclusive use of completely anonymized data, the Ethics Committee of Guilan University of Medical Sciences waived the requirement for informed consent. The investigators neither accessed nor retained any identifiable information, and all analyses were performed solely on de-identified records. |
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| Contributed Indexing: | Keywords: Chest radiography; Nephrolithiasis; Radiographic findings; Sarcoidosis |
| Entry Date(s): | Date Created: 20260513 Date Completed: 20260714 Latest Revision: 20260714 |
| Update Code: | 20260714 |
| DOI: | 10.1038/s41598-026-52030-8 |
| PMID: | 42129239 |
| Database: | MEDLINE |
Journal Article