Residual Angina Following Complete Revascularization in the ISCHEMIA Trial: Frequency, Clinical Characteristics, Health Status, and Cardiovascular Outcomes.
| Title: | Residual Angina Following Complete Revascularization in the ISCHEMIA Trial: Frequency, Clinical Characteristics, Health Status, and Cardiovascular Outcomes. |
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| Authors: | Singh A; Division of Cardiovascular Medicine Keck School of Medicine, University of Southern California Los Angeles CA USA.; Brown DL; Division of Cardiovascular Medicine Keck School of Medicine, University of Southern California Los Angeles CA USA.; Jones PG; University of Missouri-Kansas City's Healthcare Institute for Innovations in Quality and Saint Luke's Mid America Heart Institute Kansas City MO USA.; Fu Z; University of Missouri-Kansas City's Healthcare Institute for Innovations in Quality and Saint Luke's Mid America Heart Institute Kansas City MO USA.; Reynolds HR; Cardiovascular Clinical Research Center, Leon H. Charney Division of Cardiology, Department of Medicine NYU Grossman School of Medicine New York NY USA.; Boden WE; VA New England Healthcare System Boston MA USA.; O'Brien SM; Duke Clinical Research Institute Durham NC USA.; Mavromatis K; Atlanta VA Healthcare System Atlanta GA USA.; Emory University School of Medicine Atlanta GA USA.; Poh KK; National University Heart Center Singapore and the Yong Loo Lin School of Medicine National University of Singapore Singapore.; Ali Z; Department of Cardiology St Francis Hospital and Heart Center Roslyn NY USA.; Cardiovascular Research Foundation New York NY USA.; Stone GW; Icahn School of Medicine at Mount Sinai New York NY USA.; Bangalore S; Cardiovascular Clinical Research Center, Leon H. Charney Division of Cardiology, Department of Medicine NYU Grossman School of Medicine New York NY USA.; Spertus JA; University of Missouri-Kansas City's Healthcare Institute for Innovations in Quality and Saint Luke's Mid America Heart Institute Kansas City MO USA.; Maron DJ; Department of Medicine Stanford University School of Medicine Stanford CA USA.; Hochman JS; Cardiovascular Clinical Research Center, Leon H. Charney Division of Cardiology, Department of Medicine NYU Grossman School of Medicine New York NY USA. |
| Corporate Authors: | ISCHEMIA Research Group |
| Source: | Journal of the American Heart Association [J Am Heart Assoc] 2026 May 19; Vol. 15 (10), pp. e047355. Date of Electronic Publication: 2026 May 14. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Multicenter Study |
| Language: | English |
| Journal Info: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford : Wiley-Blackwell |
| MeSH Terms: | Angina Pectoris*/diagnosis ; Angina Pectoris*/etiology ; Angina Pectoris*/mortality ; Angina Pectoris*/epidemiology ; Coronary Artery Bypass*/adverse effects ; Percutaneous Coronary Intervention*/adverse effects ; Percutaneous Coronary Intervention*/mortality ; Myocardial Revascularization*/adverse effects ; Myocardial Revascularization*/methods ; Coronary Artery Disease*/mortality ; Coronary Artery Disease*/surgery ; Coronary Artery Disease*/diagnosis ; Coronary Artery Disease*/therapy ; Health Status*; Cardiovascular Agents/therapeutic use ; Humans ; Male ; Female ; Middle Aged ; Aged ; Treatment Outcome ; Time Factors ; Quality of Life |
| Abstract: | Background: The frequency of residual angina and its impact on health status and death following anatomic complete revascularization in symptomatic patients with chronic coronary disease are unknown.; Methods: Data were analyzed from ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) trial participants randomized to invasive management with baseline angina (Seattle Angina Questionnaire Angina Frequency score |
| Contributed Indexing: | Keywords: angina; chronic coronary disease; revascularization |
| Molecular Sequence: | ClinicalTrials.gov NCT01471522 |
| Substance Nomenclature: | 0 (Cardiovascular Agents) |
| Entry Date(s): | Date Created: 20260514 Date Completed: 20260519 Latest Revision: 20260519 |
| Update Code: | 20260519 |
| DOI: | 10.1161/JAHA.125.047355 |
| PMID: | 42132177 |
| Database: | MEDLINE |
Journal Article; Randomized Controlled Trial; Multicenter Study