Retention of fluoride in the oral cavity: A randomized clinical study with nanoencapsulated fluoride toothpaste.
| Title: | Retention of fluoride in the oral cavity: A randomized clinical study with nanoencapsulated fluoride toothpaste. |
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| Authors: | Avelino de Paiva MA; Department of Clinical and Social Dentistry, Federal University of Paraiba, João Pessoa, Paraiba, Brazil.; Moura HS; Department of Dentistry, State University of Paraíba (UEPB), Araruna, Paraíba, Brazil.; de Medeiros Souza MB; Department of Clinical and Social Dentistry, Federal University of Paraiba, João Pessoa, Paraiba, Brazil.; Júnior AA; Department of Clinical and Social Dentistry, Federal University of Paraiba, João Pessoa, Paraiba, Brazil.; Bezerra de Oliveira AF; Department of Morphology, Federal University of Paraiba, João Pessoa, Paraiba, Brazil.; Sampaio FC; Department of Clinical and Social Dentistry, Federal University of Paraiba, João Pessoa, Paraiba, Brazil. |
| Source: | Journal of clinical and experimental dentistry [J Clin Exp Dent] 2026 Mar 30; Vol. 18 (4), pp. e441-e448. Date of Electronic Publication: 2026 Mar 30 (Print Publication: 2026). |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Medicina Oral Country of Publication: Spain NLM ID: 101603132 Publication Model: eCollection Cited Medium: Print ISSN: 1989-5488 (Print) Linking ISSN: 19895488 NLM ISO Abbreviation: J Clin Exp Dent Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [Spain] : Medicina Oral |
| Abstract: | Background: To evaluate in vivo fluoride retention in saliva and dental biofilm after the use of experimental toothpaste containing nanoencapsulated fluoride (NanoF).; Material and Methods: A triple-blind randomized clinical study involving sixty-one residents from a municipality without fluoridated drinking water. The toothpastes used in the study were: Group 1 (1100 ppm, 100% NanoF); Group 2 (1100 ppm, 50% free NaF + 50% NanoF); and Group 3 (1100 ppm, 100% free NaF). During the use of the toothpaste, samples of dental biofilm and stimulated saliva were collected. Collection times were 1 and 2 hours (h) post-brushing for biofilm, and 1, 5, 10, 15, 20, 30, 45, 60 minutes, and 2h for saliva. The fluoride [F] concentrations in saliva and dental biofilm were analyzed using a specific electrode through the hexamethyldisiloxane (HMDS) facilitated diffusion technique. The data were analyzed using the Kruskal-Wallis, Friedman, and Wilcoxon tests (p G2 (84.73) > G1 (54.98). For dental biofilm, the highest fluoride [F] concentration was observed in G1 (35.26 mg/kg), followed by G3 (34.06 mg/kg) at the 1-hour mark; at 2 hours, the results were 24.88 mg/kg and 31.43 mg/kg, respectively, with a significant reduction in [F] observed only in G1 (p=0.02).; Conclusions: The nanoencapsulated fluoride tested in this study exhibited a distinct pattern of fluoride release in saliva. However, in dental biofilm, the release pattern was similar to that of the free fluoride formulation (NaF).; (Copyright: © 2026 Medicina Oral S.L.) |
| Competing Interests: | The authors declare that they have no conflicts of interest. |
| Entry Date(s): | Date Created: 20260515 Date Completed: 20260515 Latest Revision: 20260515 |
| Update Code: | 20260515 |
| PubMed Central ID: | PMC13170946 |
| DOI: | 10.4317/jced.63567 |
| PMID: | 42136694 |
| Database: | MEDLINE |
Journal Article; Review