| Title: |
In vitro and in vivo anticryptococcal activities of a new pyrazolo-isothiazole derivative. |
| Authors: |
Barchiesi, Francesco; Milici, Maria E.; Arzeni, Daniela; Schimizzi, Anna M.; Pizzo, Giuseppe; Giammanco, Giovanni M.; Giannini, Daniele; Manfrini, Maurizio; Scalise, Giorgio; Vicentini, Chiara B. |
| Source: |
Journal of Antimicrobial Chemotherapy (JAC); Jan2003, Vol. 51 Issue 1, p167-170, 4p |
| Abstract: |
We investigated the activity of a pyrazolo-isothiazole derivative (G8) against Cryptococcus neoformans. A first screening test showed that G8 at 10 mg/L inhibited the growth of 14 of 15 clinical isolates tested. Killing experiments showed that fungicidal activity was achieved after 8 h of treatment with G8 at concentrations > or =10 mg/L. In a murine model of systemic cryptococcosis, G8 was effective at prolonging survival compared with the controls. Our data indicate that this new derivative has a potential therapeutic role in infections caused by C. neoformans. [ABSTRACT FROM AUTHOR] |
| : |
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| Database: |
Complementary Index |