| Title: |
Activity of the new antifungal triazole, posaconazole, against Cryptococcus neoformans. |
| Authors: |
Barchiesi, Francesco; Schimizzi, Anna Maria; Caselli, Francesca; Giannini, Daniele; Camiletti, Valeria; Fileni, Barbara; Giacometti, Andrea; Francesco, Luigi Falconi Di; Scalise, Giorgio; Barchiesi, F; Schimizzi, A M; Caselli, F; Giannini, D; Camiletti, V; Fileni, B; Giacometti, A; Di Francesco, L F; Scalise, G |
| Source: |
Journal of Antimicrobial Chemotherapy (JAC); Dec2001, Vol. 48 Issue 6, p769-773, 5p |
| Abstract: |
The new antifungal derivative posaconazole was tested against three clinical isolates of Cryptococcus neoformans var. neoformans using a broth microdilution procedure performed according to the guidelines established by the NCCLS. Posaconazole MICs were 0.125, 0.25 and 1.0 mg/L for isolates 491, 2337 and 486, respectively. To investigate the in vivo activity of this new compound, we established an experimental model of systemic cryptococcosis in CD1 mice by iv injection of cells of each strain of C. neoformans. Low (3 mg/kg/day) and high (10 mg/kg/day) doses of posaconazole were compared with amphotericin B given at 0.3 mg/kg/day for 10 consecutive days. Survival studies showed that all treatment regimens were effective in prolonging the survival of mice infected with C. neoformans 486 (P < 0.001). Only posaconazole at 10 mg/kg and amphotericin B were effective in prolonging the survival in mice infected with C. neoformans 2337 (P from |
| : |
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| Database: |
Complementary Index |