Bronchospasm mechanisms in experimental microbial sensitization. II. Pathochemical stage.
| Title: | Bronchospasm mechanisms in experimental microbial sensitization. II. Pathochemical stage. |
|---|---|
| Authors: | Belyaev NN; Sukhodoeva GS; Beklemishev ND |
| Source: | Allergologia et immunopathologia [Allergol Immunopathol (Madr)] 1984 May-Jun; Vol. 12 (3), pp. 173-7. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Codon Publications Country of Publication: Singapore NLM ID: 0370073 Publication Model: Print Cited Medium: Print ISSN: 0301-0546 (Print) Linking ISSN: 03010546 NLM ISO Abbreviation: Allergol Immunopathol (Madr) Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2021- : [Singapore] : Codon Publications; Original Publication: Madrid : Elsevier España |
| MeSH Terms: | Allergens/*immunology ; Antigens, Bacterial/*immunology ; Bronchial Spasm/*immunology ; Hypersensitivity/*immunology; Atropine/pharmacology ; Autacoids/immunology ; Bronchi/drug effects ; Diphenhydramine/pharmacology ; Lymphokines/immunology ; Mast Cells/immunology ; Muscle Contraction/drug effects ; Animals ; Complement Activation ; Guinea Pigs ; Histamine Release ; Rats |
| Abstract: | The pathochemical mechanisms of bronchospasm have been studied using various type of experimental allergies to microbial antigens. It was established that in guinea pigs with type I allergies isolated lung bronchospasm was mediated by histamine and SRS-A. Bronchial response to immune complexes type III were produced by the activation of complement with subsequent degranulation of mast cells and histamine release. Type IV hypersensitivity (lymphokine-mediated bronchospasm) was manifested without histamine, acetylcholine and mast cell involvement. The response to lymphokine was blocked by atropine. The spasmogenic y lymphokines are large molecular thermolabile substances. |
| Substance Nomenclature: | 0 (Allergens); 0 (Antigens, Bacterial); 0 (Autacoids); 0 (Lymphokines); 7C0697DR9I (Atropine); 8GTS82S83M (Diphenhydramine) |
| Entry Date(s): | Date Created: 19840501 Date Completed: 19841023 Latest Revision: 20131121 |
| Update Code: | 20260130 |
| PMID: | 6206708 |
| Database: | MEDLINE |
Journal Article