Levels of renin, angiotensin I and II, angiotensin-converting enzyme and aldosterone in infancy and childhood.
| Title: | Levels of renin, angiotensin I and II, angiotensin-converting enzyme and aldosterone in infancy and childhood. |
|---|---|
| Authors: | Fiselier TJ; Lijnen P; Monnens L; van Munster P; Jansen M; Peer P |
| Source: | European journal of pediatrics [Eur J Pediatr] 1983 Oct; Vol. 141 (1), pp. 3-7. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7603873 Publication Model: Print Cited Medium: Print ISSN: 0340-6199 (Print) Linking ISSN: 03406199 NLM ISO Abbreviation: Eur J Pediatr Subsets: MEDLINE |
| Imprint Name(s): | Publication: Berlin : Springer Verlag; Original Publication: Berlin, New York, Springer-Verlag. |
| MeSH Terms: | Aldosterone/*blood ; Angiotensin I/*blood ; Angiotensin II/*blood ; Angiotensins/*blood ; Peptidyl-Dipeptidase A/*blood ; Renin/*blood; Potassium/blood ; Sodium/blood ; Adolescent ; Age Factors ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Reference Values |
| Abstract: | Basal plasma renin activity (PRA), angiotensin I and II (AI, AII), angiotensin-converting enzyme (ACE) activity and plasma aldosterone (PA) and sodium and potassium concentration were simultaneously measured in 55 healthy recumbent children aged between 1 week and 13 years. A significant (P less than 0.001) age-related decrease for PRA (r = -0.73), AI (r = -0.72), AII (r = -0.51) and PA (r = -0.71) was observed but not for ACE (r = 0.26, P = 0.06). After correction for age the correlation between PRA or PA and AI or AII was still significant (P less than 0.005). The strong correlation between AI and AII in the group as a whole (r = 0.82, P less than 0.001) and also in separate age groups, and an AI to AII ratio which was not different between the various age groups suggest that ACE activity in this age range is not rate-limiting for AII generation. |
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| Substance Nomenclature: | 0 (Angiotensins); 11128-99-7 (Angiotensin II); 4964P6T9RB (Aldosterone); 9041-90-1 (Angiotensin I); 9NEZ333N27 (Sodium); EC 3.4.15.1 (Peptidyl-Dipeptidase A); EC 3.4.23.15 (Renin); RWP5GA015D (Potassium) |
| Entry Date(s): | Date Created: 19831001 Date Completed: 19840127 Latest Revision: 20190813 |
| Update Code: | 20260130 |
| DOI: | 10.1007/BF00445660 |
| PMID: | 6315441 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't