Low-renin, low-aldosterone hypertension and abnormal cortisol metabolism in a 19-month-old child.
| Title: | Low-renin, low-aldosterone hypertension and abnormal cortisol metabolism in a 19-month-old child. |
|---|---|
| Authors: | Fiselier TJ; Otten BJ; Monnens LA; Honour JW; van Munster PJ |
| Source: | Hormone research [Horm Res] 1982; Vol. 16 (2), pp. 107-14. |
| Publication Type: | Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0366126 Publication Model: Print Cited Medium: Print ISSN: 0301-0163 (Print) Linking ISSN: 03010163 NLM ISO Abbreviation: Horm Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, New York, Karger. |
| MeSH Terms: | Aldosterone/*blood ; Hydrocortisone/*blood ; Hypertension/*metabolism ; Renin/*blood; Cortisone/blood ; Furosemide/therapeutic use ; Hypertension/complications ; Hypertension/drug therapy ; Hypokalemia/complications ; Tetrahydrocortisol/urine ; Tetrahydrocortisone/urine ; Triamterene/therapeutic use ; Dexamethasone ; Follow-Up Studies ; Humans ; Infant ; Male |
| Abstract: | A 19-month-old boy presented with failure to thrive and polydipsia. Low-renin hypertension was diagnosed by the presence of hypertension, hypokalaemic alkalosis, suppressed plasma renin activity and low plasma aldosterone. Plasma levels and urinary excretion of other mineralocorticoids and glucocorticosteroids were low or normal. Urinary tetrahydrocortisol (THF) was increased relative to tetrahydrocortisone (THE) and also the plasma cortisol to cortisone ratio was elevated. These findings are suggestive of a decreased activity of cortisol-11 beta-hydroxysteroid dehydrogenase. Hypertension and hypokalaemia were not influenced by spironolactone and dexamethasone. Triamterene normalised serum potassium, but addition of furosemide was required for lowering blood pressure. With this treatment catch-up growth was observed. |
| Substance Nomenclature: | 4964P6T9RB (Aldosterone); 5HF9TM2D15 (Tetrahydrocortisone); 7LXU5N7ZO5 (Furosemide); 7P2O6MFN8O (Tetrahydrocortisol); 7S5I7G3JQL (Dexamethasone); EC 3.4.23.15 (Renin); V27W9254FZ (Cortisone); WI4X0X7BPJ (Hydrocortisone); WS821Z52LQ (Triamterene) |
| Entry Date(s): | Date Created: 19820101 Date Completed: 19821029 Latest Revision: 20180215 |
| Update Code: | 20260130 |
| DOI: | 10.1159/000179490 |
| PMID: | 7049881 |
| Database: | MEDLINE |
Case Reports; Journal Article; Research Support, Non-U.S. Gov't