Role of schistosomiasis in human bladder cancer: evidence of association, aetiological factors, and basic mechanisms of carcinogenesis.
| Title: | Role of schistosomiasis in human bladder cancer: evidence of association, aetiological factors, and basic mechanisms of carcinogenesis. |
|---|---|
| Authors: | Badawi AF; National Center for Toxicological Research, Jefferson AF 72079, USA.; Mostafa MH; Probert A; O'Connor PJ |
| Source: | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) [Eur J Cancer Prev] 1995 Feb; Vol. 4 (1), pp. 45-59. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| Language: | English |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9300837 Publication Model: Print Cited Medium: Print ISSN: 0959-8278 (Print) Linking ISSN: 09598278 NLM ISO Abbreviation: Eur J Cancer Prev Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Lippincott Williams & Wilkins; Original Publication: Oxford, UK : Rapid Communications of Oxford, c1991- |
| MeSH Terms: | Schistosomiasis haematobia/*complications ; Urinary Bladder Neoplasms/*etiology; Africa/epidemiology ; Europe/epidemiology ; Schistosomiasis haematobia/epidemiology ; United States/epidemiology ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/parasitology ; Adult ; Age Factors ; Aged ; Animals ; Carcinogens ; Female ; Humans ; Male ; Middle Aged ; Sex Factors |
| Abstract: | Several epidemiological, clinical and experimental studies have been carried out to determine whether there is an aetiological role for schistosomiasis in the multi-stage process of bladder carcinogenesis. Lines of evidence supporting the association between bladder cancer and schistosomiasis include indications from the geographical correlation between the two conditions, the distinctive patterns of gender and age at diagnosis, the clinicopathological identity of schistosome-associated bladder cancer and the extensive experimental evidence in infected laboratory animals. Although the causative role of schistosomiasis is now accepted, various associated factors have been proposed in the induction of this particular type of cancer. While all may contribute to the carcinogenic process taking place in the infected bladder, none of these has yet been confirmed. Most attention has been directed at theories proposing possible roles for urinary chemical carcinogens, particularly tryptophan metabolites, N-nitroso compounds and of beta-glucuronidase, as factors that are primarily involved in the initiation of bladder carcinogenesis in areas endemic for schistosomiasis. |
| Number of References: | 136 |
| Substance Nomenclature: | 0 (Carcinogens) |
| Entry Date(s): | Date Created: 19950201 Date Completed: 19950601 Latest Revision: 20191023 |
| Update Code: | 20260130 |
| DOI: | 10.1097/00008469-199502000-00004 |
| PMID: | 7728097 |
| Database: | MEDLINE |
Journal Article; Research Support, Non-U.S. Gov't; Review