| Title: |
EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-lndependent. |
| Authors: |
Kexin Xu; Wu, Zhenhua Jeremy; Groner, Anna C.; Housheng Hansen He; Changmeng Cai; Lis, Rosina T.; Xiaoqiu Wu; Stack, Edward C.; Loda, Massimo; Tao Liu; Han Xu; Cato, Laura; Thornton, James E.; Gregory, Richard I.; Morrissey, Colm; Vessella, Robert L.; Montironi, Rodolfo; Magi-Galluzzi, Cristina; Kantoff, Philip W.; Balk, Steven P. |
| Source: |
Science (pre-March 2025); 12/14/2012, Vol. 338 Issue 6113, p1465-1469, 5p |
| Subject Terms: |
Gene enhancers; Prostate cancer; Polycomb group protein genetics; Oncogenes; Carcinogenesis; Histone methyltransferases; Phosphorylation |
| Abstract: |
Epigenetic regulators represent a promising new class of therapeutic targets for cancer. Enhancer of zeste homolog 2 (EZH2), a subunit of Polycomb repressive complex 2 (PRC2), silences gene expression via its histone methyltransferase activity. We found that the oncogenic function of EZH2 in cells of castration-resistant prostate cancer is independent of its role as a transcriptional repressor. Instead, it involves the ability of EZH2 to act as a coactivator for critical transcription factors including the androgen receptor. This functional switch is dependent on phosphorylation of EZH2 and requires an intact methyltransferase domain. Hence, targeting the non-PRC2 function of EZH2 may have therapeutic efficacy for treating metastatic, hormone-refractory prostate cancer. [ABSTRACT FROM AUTHOR] |
| : |
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| Database: |
Complementary Index |