| Title: |
Síndrome de hipersensibilidad al alopurinol. (Spanish) |
| Authors: |
Flores-Uscanga, Karen María; Álvarez-Hernández, María Dolores; Orosa-Fernández, Irma Paulina; Manríquez-Reyes, Marisol |
| Source: |
Medicina Interna de México; nov/dic2013, Vol. 29 Issue 6, p628-633, 6p |
| Subject Terms: |
ALLOPURINOL; PHYSIOLOGICAL effects of allopurinol; ALLERGIES; LIVER disease diagnosis; SEPSIS; EXANTHEMA; THERAPEUTICS |
| Abstract (English): |
The hypersensitivity drug síndrome is characterized by the triad of fever, rash and multiorgan involvement. This term encompasses different entities, that describe as common pattern a severe drug reaction; when combined with allopurinol intake has been called allopurinol hypersensitivity syndrome (AHS), with a reported mortality of up to 40% in cases with multiorgan involvement. The etiopathogenic of allopurinol hypersensitivity syndrome is not well-known, cutaneous presentation of these patients is variable the same as systemic manifestations. The diagnosis is established by the exposure to the drug, clinical, laboratory, and making differential diagnosis with other diseases. The therapeutic management so far includes suspension of the offending drug, supportive treatment and prevention of sepsis. We report the case of a 48-year-old male with chronic kidney disease, the patient was prescribed allopurinol, and four weeks after starting treatment had a severe drug reaction, which conditioned acute liver failure. [ABSTRACT FROM AUTHOR] |
| Abstract (Spanish): |
El síndrome de hipersensibilidad a fármacos se distingue por la tríada clínica de fiebre, exantema y afectación multiorgánica. Este término engloba diferentes entidades que describen, como patrón común, una reacción medicamentosa grave; cuando se asocia con la ingestión de alopurinol se denomina síndrome de hipersensibilidad al alopurinol, con mortalidad descrita de, incluso, 40% en casos con afectación multiorgánica. La etiopatogenia del síndrome de hipersensibilidad al alopurinol no es bien conocida, la manifestación cutánea es muy variable, al igual que la sistémica. El diagnóstico se establece por la exposición al fármaco, los hallazgos clínicos, de laboratorio y al realizar el diagnóstico diferencial con otras enfermedades. El tratamiento incluye, hasta el momento, la suspensión del fármaco responsable, medidas de soporte y prevención de la sepsis. Comunicamos el caso clínico de un paciente de 48 años de edad, con enfermedad renal crónica, a quien se le prescribió tratamiento con alopurinol y cuatro semanas después del inicio del tratamiento con este fármaco tuvo una reacción medicamentosa grave que condicionó insuficiencia hepática aguda fulminante. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |