Sucrose acetate isobutyrate (SAIB): three-generation reproduction study in the rat and teratology studies in the rat and rabbit.
| Title: | Sucrose acetate isobutyrate (SAIB): three-generation reproduction study in the rat and teratology studies in the rat and rabbit. |
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| Authors: | Mackenzie KM; Hazleton Wisconsin, Inc., Madison 53707, USA.; Henwood SM; Tisdel PJ; Boysen BG; Palmer TE; Schardein JL; West AJ; Chappel CI |
| Source: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 1998 Feb; Vol. 36 (2), pp. 135-40. |
| Publication Type: | Comparative Study; Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print Cited Medium: Print ISSN: 0278-6915 (Print) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Exeter : Elsevier Science Ltd; Original Publication: Oxford ; New York : Pergamon Press, c1982- |
| MeSH Terms: | Food Additives/*toxicity ; Reproduction/*drug effects ; Sucrose/*analogs & derivatives; Fertility/drug effects ; Litter Size/drug effects ; Sucrose/administration & dosage ; Sucrose/toxicity ; Animal Feed ; Animals ; Dose-Response Relationship, Drug ; Female ; Male ; No-Observed-Adverse-Effect Level ; Pregnancy ; Rabbits ; Rats ; Rats, Inbred F344 ; Species Specificity |
| Abstract: | A three-generation reproduction study of sucrose acetate isobutyrate (SAIB) in Fischer 344 rats and teratology studies in Fischer 344 rats and New Zealand white rabbits were performed. Dietary SAIB concentrations to provide dose levels of 0, 0.5, 1.0 and 2.0 g/kg body weight were used for the rat studies, and 0, 0.5, 0.85 and 1.2 g/kg body weight doses of SAIB in corn oil were administered by gavage in the rabbit studies. F0 generation male rats were fed SAIB for 10 wk, and female rats were fed SAIB for 2 wk prior to mating. F1 generation rats were raised on the test diets to maturity, mated to produce F2a litters, and remated to produce the F2b litters that were examined for teratology. F2a rats were mated to study fertility indices for the F3 pregnancy. A decrease in female fertility compared with controls was noted at the highest dose of SAIB during breeding of the F1 generation to produce the F2a litters. No difference in fertility rate between controls and treated animals was noted in the results of the other three matings that were performed, and it was concluded that the reduction in female fertility was not related to SAIB treatment. No morphological abnormalities of soft tissue or skeleton were observed in the rat or rabbit teratology studies. The highest dose levels administered, 2.0 g SAIB/kg body weight in the rat and 1.2 g SAIB/kg body weight in the rabbit, were considered to be no-observed-adverse effect levels (NOAEL). |
| Substance Nomenclature: | 0 (Food Additives); 57-50-1 (Sucrose); H5KI1C3YTV (sucrose acetate isobutyrate); O7704K0GMS (sucrose octaisobutyrate) |
| Entry Date(s): | Date Created: 19980331 Date Completed: 19980414 Latest Revision: 20190831 |
| Update Code: | 20260130 |
| DOI: | 10.1016/s0278-6915(97)80304-3 |
| PMID: | 9519852 |
| Database: | MEDLINE |
Comparative Study; Journal Article