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Correlation of 2 Hour, 4 Hour, 8 Hour and 12 Hour Urine Protein with 24 Hour Urinary Protein in Preeclampsia.

Title: Correlation of 2 Hour, 4 Hour, 8 Hour and 12 Hour Urine Protein with 24 Hour Urinary Protein in Preeclampsia.
Authors: Singhal, Savita Rani; Ghalaut, Veena; Lata, Shashi; Madaan, Himanshu; Kadian, Veenu; Sachdeva, Ashuma
Source: Journal of Family & Reproductive Health; Sep2014, Vol. 8 Issue 3, p131-134, 4p
Subject Terms: URINE proteins; PROTEINURIA; PREECLAMPSIA; PREGNANCY complications; ALBUMINS; PATIENT compliance; MATERNAL health
Abstract: Objective: To find shortest and reliable time period of urine collection for determination of proteinuria. Materials and methods: It is a prospective study carried out on 125 pregnant women with preeclampsia after 20 weeks of gestation having urine albumin ≥1 using dipstick test. Urine was collected in five different time intervals in colors labeled containers with the assistance of nursing staff; the total collection time was 24 hours. Total urine protein of two-hour, four-hour, eight-hour, 12-hour and 24-hour urine was measured and compared with 24-hour collection. Data was analyzed using the Pearson correlation coefficient. Results: There was significant correlation (p value < 0.01) in two, four, eight and 12-hour urine protein with 24-urine protein, with correlation coefficient of 0.97, 0.97, 0.96 and 0.97, respectively. When a cut off value of 25 mg, 50 mg. 100 mg, and 150 mg for urine protein were used for 2-hour, 4-hours, 8-hour and 12-hour urine collection, a sensitivity of 92.45%, 95.28%, 91.51%, and 96.23% and a specificity of 68.42%, 94.74%, 84.21% and 84.21% were obtained, respectively. Conclusion: Two-hour urine proteins can be used for assessment of proteinuria in preeclampsia instead of gold standard 24-hour urine collection for early diagnosis and better patient compliance. [ABSTRACT FROM AUTHOR]
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Database: Complementary Index