Anti-MRSA activity of sophoraflavanone G and synergism with other antibacterial agents.
| Title: | Anti-MRSA activity of sophoraflavanone G and synergism with other antibacterial agents. |
|---|---|
| Authors: | Sakagami Y; Osaka Prefectural Institute of Public Health, Japan.; Mimura M; Kajimura K; Yokoyama H; Linuma M; Tanaka T; Ohyama M |
| Source: | Letters in applied microbiology [Lett Appl Microbiol] 1998 Aug; Vol. 27 (2), pp. 98-100. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8510094 Publication Model: Print Cited Medium: Print ISSN: 0266-8254 (Print) Linking ISSN: 02668254 NLM ISO Abbreviation: Lett Appl Microbiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2023- : Oxford : Oxford University Press; Original Publication: Oxford, UK : Published for the Society for Applied Bacteriology by Blackwell Scientific Publications, [c1985- |
| MeSH Terms: | Anti-Bacterial Agents/*pharmacology ; Plant Extracts/*pharmacology ; Staphylococcus aureus/*drug effects; Plants, Medicinal/chemistry ; Staphylococcus aureus/growth & development ; Drug Synergism ; Humans ; Methicillin Resistance ; Microbial Sensitivity Tests ; Sesquiterpenes ; Terpenes ; Phytoalexins |
| Abstract: | Anti-MRSA activity of sophoraflavanone G (SFG) and synergism between SFG and antibacterial agents against MRSA (methicillin-resistant Staphylococcus aureus) were evaluated by means of Minimal Inhibitory Concentrations (MIC). The MICs of SFG against 27 strains of MRSA ranged from 3.13 to 6.25 micrograms ml-1. Synergism between SFG and vancomycin hydrochloride (VCM) or fosfomycin (FOM) was observed (the fraction inhibitory concentration (FIC) indices were 0.16 and 0.48), while partial synergism was admitted between SFG and other antibacterial agents such as methicillin (DMPPC), cefzonam (CZON), gentamicin (GM), minocycline (MINO) and levofloxacin (LVFX) (the FIC indices were 0.71, 0.73, 0.69, 0.65 and 0.58, respectively). These findings suggest that SFG in combination with VCM or FOM may be useful in controlling MRSA infections. |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (Terpenes); 0 (Phytoalexins) |
| Entry Date(s): | Date Created: 19980929 Date Completed: 19981023 Latest Revision: 20221207 |
| Update Code: | 20260130 |
| DOI: | 10.1046/j.1472-765x.1998.00386.x |
| PMID: | 9750330 |
| Database: | MEDLINE |
Journal Article