| Title: |
Sugammadex -- the solution to our relaxant problems? |
| Authors: |
Badgery, Henry1 hebad2@student.monash.edu |
| Source: |
Australian Medical Student Journal. 2013, Vol. 4 Issue 2, p33-36. 4p. |
| Subject Terms: |
*SUGAMMADEX; *MUSCLE relaxants; *NEUROMUSCULAR blocking agents; *DRUG side effects; *CYCLODEXTRINS |
| Abstract: |
Sugammadex is the first of a class of selective relaxant binding agents. It acts by binding with high affinity to steroidal non-depolarising neuromuscular blockade drugs terminating neuromuscular blockade (NMB) through 1:1 encapsulation. Reversal of NMB has traditionally been performed by acetylcholinesterase inhibitors however these drugs have their drawbacks and are therefore not ideal. This review examines the indications and advantages of sugammadex as well as the potential risks and shortcomings associated with its use. Sugammadex is a relatively new drug that has been shown to be efficacious with an improved side effect profile as compared to its alternatives however several factors associated with its use have yet to be determined. These shortcomings have relevance on a therapeutic level as well as on a health economics level. [ABSTRACT FROM AUTHOR] |
| Database: |
Academic Search Index |