| Title: |
The Association between Repeated Measured Febrile Episodes during Early Childhood and Attention Deficit Hyperactivity Disorder: A Large-Scale Population-Based Study |
| Language: |
English |
| Authors: |
Ariel Israel; Eugene Merzon (ORCID 0000-0001-5469-0236); Beth Krone (ORCID 0000-0003-4046-8305); Stephen V. Faraone; Ilan Green; Avivit Golan Cohen; Shlomo Vinker; Shira Cohen; Shai Ashkenazi; Eli Magen; Abraham Weizman (ORCID 0000-0002-9765-8938); Iris Manor (ORCID 0000-0002-0642-0028) |
| Source: |
Journal of Attention Disorders. 2024 28(5):677-685. |
| Availability: |
SAGE Publications. 2455 Teller Road, Thousand Oaks, CA 91320. Tel: 800-818-7243; Tel: 805-499-9774; Fax: 800-583-2665; e-mail: journals@sagepub.com; Web site: https://sagepub.com |
| Peer Reviewed: |
Y |
| Page Count: |
9 |
| Publication Date: |
2024 |
| Document Type: |
Journal Articles; Reports - Research |
| Descriptors: |
Physiology; Young Children; Incidence; Attention Deficit Hyperactivity Disorder; Correlation; Children; Adolescents; Probability; Neurology; Foreign Countries |
| Geographic Terms: |
Israel |
| DOI: |
10.1177/10870547231215289 |
| ISSN: |
1087-0547; 1557-1246 |
| Abstract: |
Objective: We examined the association between the number, magnitude, and frequency of febrile episodes during the 0 to 4 years of life and subsequent diagnosis of ADHD. Methods: This population-based case-control study in an Israeli HMO, Leumit Health Services (LHS), uses a database for all LHS members aged 5 to 18 years between 1/1/2002 and 1/30/2022. The number and magnitude of measured fever episodes during the 0 to 4 years were recorded in individuals with ADHD (N = 18,558) and individually matched non-ADHD controls in a 1:2 ratio (N = 37,116). Results: A significant, independent association was found between the number and magnitude of febrile episodes during the 0 to 4 years and the probability of a later diagnosis of ADHD. Children who never had a measured temperature >37.5°C had a significantly lower rate of ADHD (OR = 0.834, 95% CI [0.802, 0.866], p < 0.0001). Conclusions: Febrile episodes during 0 to 4 years are associated with a significantly increased rate of a later diagnosis of ADHD in a dose-response relationship. |
| Abstractor: |
As Provided |
| Entry Date: |
2024 |
| Accession Number: |
EJ1440635 |
| Database: |
ERIC |